GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
SCAP
FullNmae
SREBF chaperone
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:30634
EnsembleID
ENSG00000114650
Uniprot
Q12770
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
SCAP
cuproptosis
36010978
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1.
Cuproptosis-related genes
Go Annotation:
GeneSymbol
Go id
SCAP
GO:0000139,GO:0000139,GO:0001666,GO:0005515,GO:0005783,GO:0005789,GO:0005789,GO:0005794,GO:0006955,GO:0008203,GO:0012507,GO:0016020,GO:0032868,GO:0032933,GO:0032933,GO:0032934,GO:0032936,GO:0042304,GO:0044255,GO:0044877,GO:0045540,GO:0045541,GO:0045542,GO:0051082,GO:0090110
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
ETS1
SCAP
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
GATA2
SCAP
19941826
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
YBX1
SCAP
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
PRDM14
SCAP
18971253
20953172
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
SMARCA4
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOS
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
MITF
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
TRIM28
SCAP
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00000DDD35
SCAP
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS00005651EE
SCAP
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS000016D2D4
SCAP
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
SCAP
INSIG1
25361965
interaction type
N/A
PTMCode2
INSIG1
SCAP
25361965
interaction type
N/A
PTMCode2
Source
Target
Pmid
Interactiontype
Methods
Database
INSIG2
SCAP
12242332
12482938
14525934
16549805
25348397
27898060
N/A
experimental interaction detection,physical interaction,in vitro,in vivo
ComPPI,HPRD,OmniPath
SREBF1
SCAP
25348397
N/A
physical interaction
ComPPI
SREBF2
SCAP
10896675
14525934
25348397
27898060
N/A
experimental interaction detection,physical interaction,in vitro,in vivo
ComPPI,HPRD,OmniPath
VCAM1
SCAP
22623428
24234451
25348397
association
cross-linking study
ComPPI,IntAct
RNF139
SCAP
25348397
N/A
physical interaction
ComPPI
SCAP
INSIG1
12202038
12482938
12842885
14525934
25348397
N/A
experimental interaction detection,physical interaction,in vitro,in vivo
ComPPI,HPRD
SCAP
PGRMC1
14525934
15782218
25348397
N/A
experimental interaction detection,in vivo
ComPPI,HPRD
SCAP
SEC24B
25348397
N/A
physical interaction
ComPPI
SCAP
ERLIN2
25348397
N/A
physical interaction
ComPPI
SCAP
MOV10
25348397
N/A
physical interaction
ComPPI
SCAP
NXF1
25348397
N/A
physical interaction
ComPPI
SCAP
MCOLN3
25348397
N/A
physical interaction
ComPPI
SCAP
NAALADL2
25348397
N/A
physical interaction
ComPPI
SCAP
HLA-C
25348397
N/A
physical interaction
ComPPI
SCAP
ATP1B4
25348397
N/A
physical interaction
ComPPI
SCAP
BTNL8
25348397
N/A
physical interaction
ComPPI
SCAP
LPAR1
25348397
N/A
physical interaction
ComPPI
SCAP
GLRA2
25348397
N/A
physical interaction
ComPPI
SCAP
RPTOR
25348397
N/A
physical interaction
ComPPI
SCAP
IPPK
25348397
N/A
physical interaction
ComPPI
SCAP
ZNRF4
25348397
N/A
physical interaction
ComPPI
SCAP
B4GAT1
25348397
N/A
physical interaction
ComPPI
SCAP
NUDC
24234451
25036637
25348397
physical association
luminescence based mammalian interactome mapping
ComPPI,IntAct
SCAP
SCAP
14525934
15782218
N/A
experimental interaction detection
HPRD
AR
SCAP
15133039
27898060
stimulant
N/A
OmniPath
Visualization