Gene Information gene info

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GENE：SDHB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SDHB
FullNmae succinate dehydrogenase complex iron sulfur subunit B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10681
EnsembleID ENSG00000117118
Uniprot P21912

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SDHB cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
SDHB cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
SDHB cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SDHB GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005743,GO:0005749,GO:0005749,GO:0005886,GO:0006099,GO:0006099,GO:0006121,GO:0008177,GO:0009055,GO:0009060,GO:0022904,GO:0031966,GO:0042776,GO:0046872,GO:0048039,GO:0051537,GO:0051538,GO:0051539,GO:0102040

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SDHB hsa:6390 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
SDHB hsa:6390 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
SDHB hsa:6390 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SDHB hsa:6390 path:hsa01200 Carbon metabolism - Homo sapiens (human)
SDHB hsa:6390 path:hsa04714 Thermogenesis - Homo sapiens (human)
SDHB hsa:6390 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
SDHB hsa:6390 path:hsa05010 Alzheimer disease - Homo sapiens (human)
SDHB hsa:6390 path:hsa05012 Parkinson disease - Homo sapiens (human)
SDHB hsa:6390 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
SDHB hsa:6390 path:hsa05016 Huntington disease - Homo sapiens (human)
SDHB hsa:6390 path:hsa05020 Prion disease - Homo sapiens (human)
SDHB hsa:6390 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
SDHB hsa:6390 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
SDHB hsa:6390 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SDHB GFI1 19506020 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR SDHB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SDHB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SDHB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SDHB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A SDHB 17102089 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L2 SDHB 9492280 trascriptional regulation,stimulation inferred by curator TFlink
NRF1 SDHB 9492280 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L1 SDHB 9492280 trascriptional regulation,stimulation inferred by curator TFlink
PLAGL1 SDHB 19423711 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 SDHB 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
SDHC SDHB 25361965 interaction type N/A PTMCode2
SDHB SDHC 25361965 interaction type N/A PTMCode2
SDHB FXN 25361965 interaction type N/A PTMCode2
FXN SDHB 25361965 interaction type N/A PTMCode2
DLD SDHB 25361965 interaction type N/A PTMCode2
SDHB DLD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXLNA SDHB 25348397 N/A physical interaction ComPPI
GEM SDHB 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NDUFB9 SDHB 25348397 N/A physical interaction ComPPI
SPRY2 SDHB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LDHA SDHB 25348397 N/A physical interaction ComPPI
ATP5F1B SDHB 25348397 N/A physical interaction ComPPI
TP53BP1 SDHB 25348397 N/A physical interaction ComPPI
MRPL40 SDHB 25348397 N/A physical interaction ComPPI
RAB8A SDHB 25348397 N/A physical interaction ComPPI
JUN SDHB 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 SDHB 25348397 N/A physical interaction ComPPI
CUL3 SDHB 25348397 N/A physical interaction ComPPI
RAB7A SDHB 25348397 N/A physical interaction ComPPI
DLD SDHB 25348397 N/A physical interaction ComPPI
RBM14 SDHB 25348397 N/A physical interaction ComPPI
SSBP1 SDHB 25348397 N/A physical interaction ComPPI
POLG SDHB 25348397 N/A physical interaction ComPPI
IQGAP1 SDHB 25348397 N/A physical interaction ComPPI
PDHA2 SDHB 25348397 N/A physical interaction ComPPI
PDHA1 SDHB 25348397 N/A physical interaction ComPPI
ATP6AP2 SDHB 25348397 N/A physical interaction ComPPI
ABCE1 SDHB 25348397 N/A physical interaction ComPPI
CUL2 SDHB 25348397 N/A physical interaction ComPPI
CUL1 SDHB 25348397 N/A physical interaction ComPPI
GABARAP SDHB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPA9 SDHB 24234451 24606901 25348397 26749241 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,blue native page ComPPI,IntAct
UQCRC2 SDHB 25348397 N/A physical interaction ComPPI
VCAM1 SDHB 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
ITGA4 SDHB 25348397 N/A physical interaction ComPPI
ATXN3 SDHB 25348397 N/A physical interaction ComPPI
PRDX6 SDHB 25348397 N/A physical interaction ComPPI
DLAT SDHB 25348397 N/A physical interaction ComPPI
FXN SDHB 15961414 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XRN1 SDHB 25348397 N/A physical interaction ComPPI
CAND1 SDHB 25348397 N/A physical interaction ComPPI
SUCLA2 SDHB 25348397 N/A physical interaction ComPPI
PDK1 SDHB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ABCA1 SDHB 12054535 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SPNS1 SDHB 12815463 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
CLPX SDHB 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
CLPP SDHB 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
PIK3R5 SDHB 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TOP3A SDHB 25348397 N/A physical interaction ComPPI
MAT2A SDHB 25348397 N/A physical interaction ComPPI
LAMTOR2 SDHB 25348397 N/A physical interaction ComPPI
IKBKE SDHB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GPI SDHB 25348397 N/A physical interaction ComPPI
TOMM7 SDHB 25348397 N/A physical interaction ComPPI
SUCLG1 SDHB 25348397 N/A physical interaction ComPPI
TIMM50 SDHB 25348397 N/A physical interaction ComPPI
TOMM40 SDHB 25348397 N/A physical interaction ComPPI
HSPD1 SDHB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DUSP13 SDHB 25348397 N/A physical interaction ComPPI
NDUFV2 SDHB 25348397 N/A physical interaction ComPPI
GSN SDHB 25348397 N/A physical interaction ComPPI
ACLY SDHB 25348397 N/A physical interaction ComPPI
CS SDHB 25348397 N/A physical interaction ComPPI
MDH2 SDHB 25348397 N/A physical interaction ComPPI
AGL SDHB 25348397 N/A physical interaction ComPPI
MCC SDHB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SLC25A5 SDHB 24234451 24983503 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFV1 SDHB 25348397 N/A physical interaction ComPPI
UQCRB SDHB 25348397 N/A physical interaction ComPPI
SIRT3 SDHB 25348397 N/A physical interaction ComPPI
GABARAPL1 SDHB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MRPL20 SDHB 25348397 N/A physical interaction ComPPI
SLC25A3 SDHB 25348397 N/A physical interaction ComPPI
IWS1 SDHB 25348397 N/A physical interaction ComPPI
COX4I1 SDHB 25348397 N/A physical interaction ComPPI
UQCRFS1 SDHB 25348397 N/A physical interaction ComPPI
NIPSNAP3A SDHB 25348397 N/A physical interaction ComPPI
ILVBL SDHB 25348397 N/A physical interaction ComPPI
MGST3 SDHB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VDAC3 SDHB 25348397 N/A physical interaction ComPPI
ACP6 SDHB 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFA6 SDHB 25348397 N/A physical interaction ComPPI
COQ9 SDHB 25348397 N/A physical interaction ComPPI
PREPL SDHB 25348397 N/A physical interaction ComPPI
MTCH2 SDHB 25348397 N/A physical interaction ComPPI
SDHB SDHA 19688755 24234451 24606901 25348397 26749241 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,blue native page ComPPI,IntAct
SDHB SLC25A22 25348397 N/A physical interaction ComPPI
SDHB MRPL45 25348397 N/A physical interaction ComPPI
SDHB HNRNPUL2 25348397 N/A physical interaction ComPPI
SDHB NDUFA10 25348397 N/A physical interaction ComPPI
SDHB NDUFB6 25348397 N/A physical interaction ComPPI
SDHB NDUFB11 25348397 N/A physical interaction ComPPI
SDHB NDUFA9 25348397 N/A physical interaction ComPPI
SDHB MRPS10 25348397 N/A physical interaction ComPPI
SDHB TMED2 25348397 N/A physical interaction ComPPI
SDHB MRPS5 25348397 N/A physical interaction ComPPI
SDHB OXA1L 25348397 N/A physical interaction ComPPI
SDHB NDUFS1 25348397 N/A physical interaction ComPPI
SDHB ACAT1 25348397 N/A physical interaction ComPPI
SDHB PIGS 25348397 N/A physical interaction ComPPI
SDHB OCIAD1 25348397 N/A physical interaction ComPPI
SDHB CISD1 25348397 N/A physical interaction ComPPI
SDHB GPD2 25348397 N/A physical interaction ComPPI
SDHB MT-CO2 25348397 N/A physical interaction ComPPI
SDHB NDUFA12 25348397 N/A physical interaction ComPPI
SDHB NDUFA2 25348397 N/A physical interaction ComPPI
SDHB NDUFS4 25348397 N/A physical interaction ComPPI
SDHB MRPL48 25348397 N/A physical interaction ComPPI
SDHB NDUFS8 25348397 N/A physical interaction ComPPI
SDHB SDHC 25348397 N/A physical interaction ComPPI
SDHB UBXN10 25348397 N/A physical interaction ComPPI
SDHB OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SDHB SDHAF3 25348397 N/A physical interaction ComPPI
SDHB NDUFA4 25348397 N/A physical interaction ComPPI
SDHB CARTPT 25348397 N/A physical interaction ComPPI
SDHB DUSP13 25348397 N/A physical interaction ComPPI
SDHB D2HGDH 25348397 N/A physical interaction ComPPI
SDHB ACAD11 25348397 N/A physical interaction ComPPI
SDHB PDPR 25348397 N/A physical interaction ComPPI
SDHB MMADHC 25348397 N/A physical interaction ComPPI
SDHB HARS2 25348397 N/A physical interaction ComPPI
SDHB NDUFAB1 25348397 N/A physical interaction ComPPI
SDHB ACSF3 25348397 N/A physical interaction ComPPI
SDHB RSAD1 25348397 N/A physical interaction ComPPI
SDHB LARS2 25348397 N/A physical interaction ComPPI
SDHB PTPDC1 25348397 N/A physical interaction ComPPI
SDHB SDHAF1 24234451 24606901 25348397 26749241 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SDHB ISCU 24234451 24606901 25348397 26749241 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SDHB COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
UAP1 SDHB 25348397 N/A physical interaction ComPPI
HSCB SDHB 24234451 24606901 25348397 26749241 28380382 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct
SDHAF2 SDHB 19628817 23043141 27898060 stimulant N/A OmniPath

Visualization










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