Gene Information gene info

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GENE：SDHC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SDHC
FullNmae succinate dehydrogenase complex subunit C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10682
EnsembleID ENSG00000143252
Uniprot Q99643

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SDHC cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration

Go Annotation:

GeneSymbol Go id
SDHC GO:0000104,GO:0005515,GO:0005739,GO:0005743,GO:0005743,GO:0005743,GO:0005749,GO:0005749,GO:0005749,GO:0005749,GO:0006099,GO:0006099,GO:0006099,GO:0006121,GO:0006121,GO:0009055,GO:0009060,GO:0016020,GO:0020037,GO:0042776,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SDHC hsa:6391 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
SDHC hsa:6391 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
SDHC hsa:6391 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SDHC hsa:6391 path:hsa01200 Carbon metabolism - Homo sapiens (human)
SDHC hsa:6391 path:hsa04714 Thermogenesis - Homo sapiens (human)
SDHC hsa:6391 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
SDHC hsa:6391 path:hsa05010 Alzheimer disease - Homo sapiens (human)
SDHC hsa:6391 path:hsa05012 Parkinson disease - Homo sapiens (human)
SDHC hsa:6391 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
SDHC hsa:6391 path:hsa05016 Huntington disease - Homo sapiens (human)
SDHC hsa:6391 path:hsa05020 Prion disease - Homo sapiens (human)
SDHC hsa:6391 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
SDHC hsa:6391 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
SDHC hsa:6391 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SDHC SDHA 19465911 26192618 interaction type N/A ACSN
SDHC SDHD 19465911 26192618 interaction type N/A ACSN
SDHC CHUK 12799363 23430059 26192618 association N/A ACSN
SDHAF1 SDHC 19465911 26192618 interaction type N/A ACSN
SDHC NFKBIA 12799363 23430059 26192618 interaction type N/A ACSN
MCL1 SDHC 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26192618 26587781 interaction type N/A ACSN
TRAF2 SDHC 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26192618 26587781 interaction type N/A ACSN
IKBKB SDHC 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
SMARCA4 SDHC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SDHC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SDHC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 SDHC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SDHC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D SDHC 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 SDHC 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD SDHC 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SDHC SDHB 25361965 interaction type N/A PTMCode2
SDHB SDHC 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARHGDIA SDHC 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRCC6 SDHC 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DCTN1 SDHC 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MDM2 SDHC 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CLPP SDHC 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A5 SDHC 24234451 24983503 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
OFD1 SDHC 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MTCH2 SDHC 25348397 N/A physical interaction ComPPI
SDHB SDHC 25348397 N/A physical interaction ComPPI
FBF1 SDHC 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NDUFS2 SDHC 25348397 N/A physical interaction ComPPI
SDHA SDHC 25348397 N/A physical interaction ComPPI
SDHC UNK 25348397 N/A physical interaction ComPPI
SDHC POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SDHC IMPDH1 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00008B8CC7 SDHC 27087310 direct interaction,inhibition N/A NPInter

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