GENE：SDHD
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SDHD |
| FullNmae | succinate dehydrogenase complex subunit D |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10683 |
| EnsembleID | ENSG00000204370 |
| Uniprot | O14521 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SDHD | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Cuproptosis genes related mitochondrial respiration |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SDHD | GO:0005515,GO:0005739,GO:0005740,GO:0005743,GO:0005743,GO:0005743,GO:0005743,GO:0005749,GO:0005749,GO:0005749,GO:0005749,GO:0006099,GO:0006099,GO:0006099,GO:0006099,GO:0006121,GO:0006121,GO:0008177,GO:0009055,GO:0020037,GO:0020037,GO:0042776,GO:0046872,GO:0048039,GO:0048039,GO:0050433,GO:0071456 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SDHD | hsa:6392 | path:hsa00020 | Citrate cycle (TCA cycle) - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05016 | Huntington disease - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| SDHD | hsa:6392 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | SDHD | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SDHD | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SDHD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SDHD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SDHD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SDHD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000055128B | SDHD | 23028679 23492775 23592263 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000424278 | SDHD | 23028679 23592263 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS000032FC1A | SDHD | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000277201 | SDHD | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC864 | SDHD | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002DD349 | SDHD | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000183BED | SDHD | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | SDHD | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F8DA | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFEC1 | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D6605 | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A71AD | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FB065 | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | SDHD | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000149319 | SDHD | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C83DA | SDHD | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SLC25A5 | SDHD | 24234451 24983503 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| COQ9 | SDHD | 25348397 | N/A | physical interaction | ComPPI |
| MTNR1B | SDHD | 24234451 25348397 26514267 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| COX6B1 | SDHD | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| F2RL1 | SDHD | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| GPR35 | SDHD | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |