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GENE：MEF2C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MEF2C
FullNmae myocyte enhancer factor 2C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6996
EnsembleID ENSG00000081189
Uniprot Q06413

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MEF2C pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MEF2C necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MEF2C immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MEF2C GO:0000122,GO:0000165,GO:0000165,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0001568,GO:0001649,GO:0001764,GO:0001782,GO:0001947,GO:0001958,GO:0001974,GO:0002062,GO:0002467,GO:0002634,GO:0002931,GO:0003138,GO:0003139,GO:0003151,GO:0003185,GO:0003211,GO:0003680,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006915,GO:0006959,GO:0007399,GO:0007507,GO:0007507,GO:0007507,GO:0007507,GO:0007517,GO:0007519,GO:0007521,GO:0007611,GO:0010628,GO:0010629,GO:0010694,GO:0014033,GO:0014902,GO:0016528,GO:0016607,GO:0030154,GO:0030182,GO:0030182,GO:0030220,GO:0030279,GO:0030318,GO:0030501,GO:0030890,GO:0032991,GO:0035984,GO:0042100,GO:0042826,GO:0043231,GO:0043410,GO:0043523,GO:0043524,GO:0043537,GO:0045652,GO:0045663,GO:0045666,GO:0045669,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0046928,GO:0046982,GO:0048167,GO:0048643,GO:0048666,GO:0048667,GO:0050853,GO:0051145,GO:0051963,GO:0051966,GO:0055012,GO:0060025,GO:0060045,GO:0060079,GO:0060998,GO:0061333,GO:0061629,GO:0071222,GO:0071277,GO:0071374,GO:0071466,GO:0071498,GO:0071560,GO:0072102,GO:0072160,GO:0098794,GO:0140297,GO:1904706,GO:1904706,GO:1904753,GO:1904753,GO:1905563,GO:1990837,GO:2000111,GO:2000310,GO:2000311,GO:2000727,GO:2000987,GO:2001013,GO:2001016

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MEF2C hsa:4208 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MEF2C hsa:4208 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
MEF2C hsa:4208 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
MEF2C hsa:4208 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
MEF2C hsa:4208 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
MEF2C hsa:4208 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
MEF2C hsa:4208 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MEF2C PTP4A3 18471976 20609352 21053359 21084277 21811102 22073279 22970020 23178297 24403062 25139404 26192618 27222233 27526109 interaction type N/A ACSN
MAPK14 MEF2C 10330143 10805738 18988627 23331499 9069290 9753748 stimulation N/A SignaLink,SignaLink
MEF2C JUN 23331499 9384584 stimulation N/A SignaLink,SignaLink
MAPK7 MEF2C 18988627 20936779 21071413 23331499 9384584 9753748 stimulation N/A SignaLink,SignaLink
SMAD3 MEF2C 15044954 23331499 stimulation N/A SignaLink,SignaLink
NOTCH1 MEF2C 10082551 18988627 23331499 stimulation N/A SignaLink,SignaLink
LTC4S MEF2C 16510869 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MEF2C 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 MEF2C 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MEF2C 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MEF2C 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MEF2C 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MEF2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GFI1B MEF2C 21261500 trascriptional regulation,stimulation inferred by curator TFlink
HDAC7 MEF2C 11585834 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 MEF2C 11585834 trascriptional regulation,stimulation inferred by curator TFlink
HIPK2 MEF2C 23620283 trascriptional regulation,stimulation inferred by curator TFlink
ISL1 MEF2C 23152444 trascriptional regulation,stimulation inferred by curator TFlink
NKX2-5 MEF2C 21261500 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D MEF2C 21170291 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS00000B7E30 MEF2C 18278031 23094093 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000B7E30 MEF2C 18278031 23094093 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D MEF2C 21170291 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 MEF2C 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000031E12 MEF2C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 MEF2C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000065FDF MEF2C 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 MEF2C 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 MEF2C 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 MEF2C 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MEF2C 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 MEF2C 25416803 26897085 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000160683 MEF2C 25416803 27796324 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000001C659 MEF2C 25416803 26184978 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000C7662 MEF2C 25416803 26184978 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 MEF2C 22135298 phosphorylation N/A PhosphoSite
MYLK2 MEF2C 22135298 phosphorylation N/A PhosphoSite
TEAD1 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C TEAD1 25361965 interaction type N/A PTMCode2
HDAC7 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C HDAC7 25361965 interaction type N/A PTMCode2
MAPK7 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C MAPK7 25361965 interaction type N/A PTMCode2
MYOD1 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C MYOD1 25361965 interaction type N/A PTMCode2
NOTCH1 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C NOTCH1 25361965 interaction type N/A PTMCode2
HDAC5 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C HDAC5 25361965 interaction type N/A PTMCode2
MAPK14 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C MAPK14 25361965 interaction type N/A PTMCode2
VGLL2 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C VGLL2 25361965 interaction type N/A PTMCode2
HDAC4 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C HDAC4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I MEF2C 25348397 N/A physical interaction ComPPI
MYOG MEF2C 25348397 N/A physical interaction ComPPI
SP1 MEF2C 14525934 25348397 27898060 9748305 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
MYOD1 MEF2C 25348397 N/A physical interaction ComPPI
NOTCH1 MEF2C 10082551 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
JUN MEF2C 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 MEF2C 11160896 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EP300 MEF2C 14525934 21556048 24234451 25348397 9001254 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
COPS5 MEF2C 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAPK14 MEF2C 10330143 10805738 14525934 20936779 24234451 25348397 9069290 9753748 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
HDAC4 MEF2C 10523670 11504882 11792813 14525934 23752268 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
YWHAZ MEF2C 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CSNK2A1 MEF2C 14525934 25348397 8663403 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK7 MEF2C 14525934 20936779 24234451 25348397 9384584 9753748 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
NCOA2 MEF2C 12130539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SPTBN1 MEF2C 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TWIST2 MEF2C 11809751 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
GATA4 MEF2C 10790371 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SKP2 MEF2C 25348397 N/A physical interaction ComPPI
TFCP2 MEF2C 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MEF2C MEF2D 14525934 25348397 9858528 N/A experimental interaction detection,in vitro ComPPI,HPRD
MEF2C SOX18 11554755 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MEF2C HDAC5 10737771 14525934 23752268 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MEF2C VGLL4 14525934 15140898 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MEF2C VGLL2 12376544 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MEF2C CCNB1 14525934 16478538 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MEF2C TEAD1 25348397 N/A physical interaction ComPPI
MEF2C EPAS1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MEF2C HDAC9 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MEF2C SIRT1 25348397 N/A physical interaction ComPPI
MEF2C HDAC7 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MEF2C IFRD1 25348397 N/A physical interaction ComPPI
MEF2C ASCL1 25348397 N/A physical interaction ComPPI
MEF2C PLA2G12A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MEF2C MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2C MEF2B 25348397 N/A physical interaction ComPPI
MEF2C HIPK2 23565059 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MEF2C MYLK2 21556048 24234451 25348397 phosphorylation reaction,physical association pull down,protein kinase assay ComPPI,IntAct
MEF2C MEF2C 12130539 14525934 N/A experimental interaction detection HPRD
CDK1 MEF2C 14525934 16478538 N/A experimental interaction detection HPRD
CDK5 MEF2C 15340086 27898060 N/A N/A OmniPath
MEF2C MYOD1 15743821 27898060 9418854 stimulant N/A OmniPath
MAPK7 MEF2C 20936779 27898060 9069290 9384584 9753748 stimulant N/A OmniPath
CREBBP MEF2C 11062529 27898060 stimulant N/A OmniPath
MAML1 MEF2C 16510869 27898060 stimulant N/A OmniPath
MAPK14 MEF2C 10330143 10805738 15340086 16478538 20936779 21902831 27898060 9069290 9384584 9753748 9858528 stimulant N/A OmniPath
CDK1 MEF2C 16478538 27898060 N/A N/A OmniPath
HDAC4 MEF2C 10523670 10737771 11279209 11486037 11504882 11792813 12709441 15743821 15964851 18332106 27898060 inhibition N/A OmniPath
CDK4 MEF2C 21902831 27898060 inhibition N/A OmniPath
EP300 MEF2C 11062529 11796223 21556048 27898060 9001254 stimulant N/A OmniPath
CSNK2A1 MEF2C 27898060 8663403 N/A N/A OmniPath
RPS6KA2 MEF2C 17630987 27898060 8663403 9069290 N/A N/A OmniPath
KAT2B MEF2C 11062529 27898060 stimulant N/A OmniPath
HDAC5 MEF2C 10737771 11062529 27898060 inhibition N/A OmniPath
MYLK2 MEF2C 21556048 27898060 stimulant N/A OmniPath
GRIP1 MEF2C 11062529 27898060 stimulant N/A OmniPath

Visualization










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