Gene Information gene info

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GENE：SEPTIN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SEPTIN1
FullNmae septin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2879
EnsembleID ENSG00000180096
Uniprot Q8WYJ6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SEPTIN1 cuproptosis 38367885 Cuproptosis score was lower in DCM and identified set of six CRGs (SEPTIN1, CLEC11A, ISG15, P3H3, SDSL, and INKA1) was positively associated with DCM and negatively correlated with cuproptosis score, which highlights the involvement of cuproptosis in DCM. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SEPTIN1 GO:0003924,GO:0005515,GO:0005525,GO:0005815,GO:0005940,GO:0007056,GO:0008021,GO:0015630,GO:0017157,GO:0030496,GO:0031105,GO:0032153,GO:0042802,GO:0051311,GO:0060090,GO:0061640,GO:0072687

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SEPTIN1 hsa:1731 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 SEPTIN1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SEPTIN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC SEPTIN1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOS SEPTIN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SEPTIN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SEPTIN1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 SEPTIN1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003CF1AD SEPTIN1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
AURKB SEPTIN1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
AMOT SEPTIN1 25348397 N/A physical interaction,two hybrid prey pooling approach ComPPI
RAD21 SEPTIN1 25348397 N/A physical interaction ComPPI
DDIT4L SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PICK1 SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBC SEPTIN1 25348397 N/A physical interaction ComPPI
GORASP2 SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MYO18A SEPTIN1 25348397 N/A physical interaction ComPPI
SDCBP SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEPTIN2 SEPTIN1 25348397 N/A physical interaction ComPPI
SEPTIN5 SEPTIN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TOLLIP SEPTIN1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SEPTIN9 SEPTIN1 25348397 N/A physical interaction ComPPI
TEX11 SEPTIN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SEPTIN4 SEPTIN1 25348397 N/A physical interaction ComPPI
SEPTIN8 SEPTIN1 25348397 N/A physical interaction ComPPI
AURKB SEPTIN1 16179162 21988832 24234451 25348397 phosphorylation reaction,colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,IntAct
SEPTIN7 SEPTIN1 25348397 N/A physical interaction ComPPI
LNX1 SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NIF3L1 SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEPTIN6 SEPTIN1 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SEPTIN3 SEPTIN1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NRDC SEPTIN1 25348397 N/A physical interaction ComPPI
SEPTIN1 APP 25348397 N/A physical interaction ComPPI
SEPTIN1 SEPTIN12 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SEPTIN1 SEPTIN11 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEPTIN1 SEPTIN10 25348397 N/A physical interaction ComPPI
SEPTIN1 ASB7 25348397 N/A physical interaction ComPPI
SEPTIN1 SEPTIN14 17922164 24234451 25348397 physical association two hybrid ComPPI,IntAct
SEPTIN1 PIH1D1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEPTIN1 DNAJB13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEPTIN1 HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MRPL12 SEPTIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEPTIN1 SEPTIN1 16189514 24234451 25416956 physical association two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach IntAct
HMGA1 SEPTIN1 24234451 30021884 physical association cross-linking study IntAct
H2BC21 SEPTIN1 24234451 30021884 physical association cross-linking study IntAct
H1-2 SEPTIN1 24234451 30021884 physical association cross-linking study IntAct
H2BC9 SEPTIN1 24234451 30021884 physical association cross-linking study IntAct
H1-5 SEPTIN1 24234451 30021884 physical association cross-linking study IntAct
SEPTIN1 CFAP69 24234451 30021884 physical association cross-linking study IntAct
H2AC4 SEPTIN1 24234451 30021884 physical association cross-linking study IntAct
AURKB SEPTIN1 16179162 19690332 20058876 21988832 27898060 N/A N/A OmniPath

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