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GENE：SLC25A3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC25A3
FullNmae solute carrier family 25 member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10989
EnsembleID ENSG00000075415
Uniprot Q00325

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC25A3 cuproptosis 36882769 The entry and departure of copper ions into and out of the cell are controlled by the copper ion transporters SLC31A1 and ATP7B, whereas the transit of copper ions through the outer and inner mitochondrial membranes is controlled by COX17 and SLC25A3, respectively. transit of copper ions
SLC25A3 cuproptosis 36882769 Cu was transported from the intermembrane space of mitochondria across the inner membrane into the mitochondrial matrix by the transmembrane transport protein solute carrier family 25 member 3 (SLC25A3) . copper transport
SLC25A3 cuproptosis 38299968 SLC25A3, located in the mitochondrial membrane, is responsible for phosphate transport between the cytoplasm and mitochondria. Although some studies have proposed its involvement in mitochondrial copper-ion transportation, the precise mechanism underlying the mediation of both phosphate and copper transport remains unclear. copper transporter
SLC25A3 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
SLC25A3 cuproptosis 38348451 Mitochondrial phosphate carrier. Mitochondrial transporters are critical for cellular energetics and may be involved in cuproptosis. CRGs in the cuproptosis pathway
SLC25A3 cuproptosis 35594843 Under physiological conditions, mitochondria have a store of Cu in the matrix that is imported via the mitochondrial carrier family protein, SLC25A3, for the assembly of the cytochrome c oxidase of the electron transport chain driver
SLC25A3 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
SLC25A3 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
SLC25A3 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
SLC25A3 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SLC25A3 GO:0005315,GO:0005739,GO:0005743,GO:0005886,GO:0015317,GO:0016020,GO:0035435,GO:0044877,GO:0070062,GO:1902600,GO:1990547

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD2 SLC25A3 18729074 23180781 physical association tandem affinity purification InnateDB
CDK2 SLC25A3 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 SLC25A3 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 SLC25A3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC SLC25A3 12747840 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SLC25A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC25A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SLC25A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SLC25A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC25A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000048BA36 SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003BBF48 SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 SLC25A3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAD2L2 SLC25A3 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
RPN1 SLC25A3 25348397 N/A physical interaction ComPPI
NPM1 SLC25A3 25348397 N/A physical interaction ComPPI
TOMM22 SLC25A3 25348397 N/A physical interaction ComPPI
PPP2R1A SLC25A3 25348397 N/A physical interaction ComPPI
UBL4A SLC25A3 25348397 N/A physical interaction ComPPI
VCP SLC25A3 25348397 N/A physical interaction ComPPI
GABARAPL2 SLC25A3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAG SLC25A3 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KEAP1 SLC25A3 25348397 N/A physical interaction ComPPI
MCM2 SLC25A3 25348397 N/A physical interaction ComPPI
TUFM SLC25A3 25348397 N/A physical interaction ComPPI
NDUFAF4 SLC25A3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ERBB2 SLC25A3 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NF2 SLC25A3 25348397 N/A physical interaction ComPPI
RPL10 SLC25A3 25348397 N/A physical interaction ComPPI
GRB2 SLC25A3 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN SLC25A3 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 SLC25A3 25348397 N/A physical interaction,tandem affinity purification ComPPI
COPS5 SLC25A3 25348397 N/A physical interaction ComPPI
CUL3 SLC25A3 25348397 N/A physical interaction ComPPI
GAPDH SLC25A3 24234451 25348397 25417112 association anti bait coimmunoprecipitation ComPPI,IntAct
RAB7A SLC25A3 25348397 N/A physical interaction ComPPI
NTRK1 SLC25A3 25348397 N/A physical interaction ComPPI
CANX SLC25A3 25348397 N/A physical interaction ComPPI
PTPN1 SLC25A3 25348397 N/A physical interaction ComPPI
HSP90B1 SLC25A3 25348397 N/A physical interaction ComPPI
MYC SLC25A3 25348397 N/A physical interaction ComPPI
TNFRSF1A SLC25A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TM9SF2 SLC25A3 25348397 N/A physical interaction ComPPI
CAD SLC25A3 25348397 N/A physical interaction ComPPI
CFTR SLC25A3 25348397 N/A physical interaction ComPPI
MAPK6 SLC25A3 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC1 SLC25A3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHX SLC25A3 25348397 N/A physical interaction ComPPI
PDHA1 SLC25A3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB1A SLC25A3 25348397 N/A physical interaction ComPPI
ANG SLC25A3 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
CLTC SLC25A3 25348397 N/A physical interaction ComPPI
HUWE1 SLC25A3 25348397 N/A physical interaction ComPPI
CUL2 SLC25A3 25348397 N/A physical interaction ComPPI
IPO7 SLC25A3 25348397 N/A physical interaction ComPPI
ATP1A1 SLC25A3 25348397 N/A physical interaction ComPPI
CDK2 SLC25A3 25348397 N/A physical interaction ComPPI
ADRB2 SLC25A3 25348397 N/A physical interaction ComPPI
EGFR SLC25A3 15657067 24189400 24234451 25348397 association anti bait coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
TUBA1A SLC25A3 24234451 25348397 29568061 association pull down ComPPI,IntAct
GABARAP SLC25A3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP1LC3A SLC25A3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NOS2 SLC25A3 25348397 N/A physical interaction ComPPI
PTEN SLC25A3 25348397 N/A physical interaction ComPPI
RIPK3 SLC25A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC25A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP6V1B1 SLC25A3 25348397 N/A physical interaction ComPPI
EED SLC25A3 25348397 N/A physical interaction ComPPI
ATXN3 SLC25A3 25348397 N/A physical interaction ComPPI
IDH3A SLC25A3 25348397 N/A physical interaction ComPPI
SSR4 SLC25A3 25348397 N/A physical interaction ComPPI
PRKN SLC25A3 25348397 N/A physical interaction ComPPI
HDAC5 SLC25A3 25348397 N/A physical interaction ComPPI
CAND1 SLC25A3 25348397 N/A physical interaction ComPPI
NFKB1 SLC25A3 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
SMURF1 SLC25A3 25348397 N/A physical interaction ComPPI
TRIM25 SLC25A3 25348397 N/A physical interaction ComPPI
TRADD SLC25A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PTPA SLC25A3 25348397 N/A physical interaction ComPPI
PPP2R1B SLC25A3 25348397 N/A physical interaction ComPPI
TOMM20 SLC25A3 25348397 N/A physical interaction ComPPI
DYRK2 SLC25A3 25348397 N/A physical interaction ComPPI
ESRRB SLC25A3 25348397 N/A physical interaction ComPPI
PPEF1 SLC25A3 24234451 25348397 28330616 association pull down ComPPI,IntAct
IQCB1 SLC25A3 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SCFD1 SLC25A3 25348397 N/A physical interaction ComPPI
RCN1 SLC25A3 25348397 N/A physical interaction ComPPI
SUGP2 SLC25A3 25348397 N/A physical interaction ComPPI
SCD SLC25A3 25348397 N/A physical interaction ComPPI
AGO2 SLC25A3 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AGO1 SLC25A3 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MRPL17 SLC25A3 25348397 N/A physical interaction ComPPI
RRP1B SLC25A3 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MTX2 SLC25A3 25348397 N/A physical interaction ComPPI
MYL12B SLC25A3 25348397 N/A physical interaction ComPPI
TOMM40 SLC25A3 25348397 N/A physical interaction ComPPI
HDGF SLC25A3 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MX1 SLC25A3 25348397 N/A physical interaction ComPPI
FUS SLC25A3 25348397 N/A physical interaction ComPPI
NDUFV2 SLC25A3 25348397 N/A physical interaction ComPPI
PC SLC25A3 25348397 N/A physical interaction ComPPI
CYLD SLC25A3 25348397 N/A physical interaction ComPPI
GABARAPL1 SLC25A3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SPG7 SLC25A3 25348397 N/A physical interaction ComPPI
MRPL20 SLC25A3 25348397 N/A physical interaction ComPPI
AIFM1 SLC25A3 25348397 N/A physical interaction ComPPI
CCT4 SLC25A3 25348397 N/A physical interaction ComPPI
SLC25A3 PPP2R2C 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL58 25348397 N/A physical interaction ComPPI
SLC25A3 AGO4 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A3 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SLC25A3 DDOST 25348397 N/A physical interaction ComPPI
SLC25A3 ATP6V0A2 25348397 N/A physical interaction ComPPI
SLC25A3 TMEM126A 25348397 N/A physical interaction ComPPI
SLC25A3 TMEM177 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFV3 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL50 25348397 N/A physical interaction ComPPI
SLC25A3 ATP6V0A1 25348397 N/A physical interaction ComPPI
SLC25A3 RPL27 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL2 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFB5 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL13 25348397 N/A physical interaction ComPPI
SLC25A3 QSOX2 25348397 N/A physical interaction ComPPI
SLC25A3 TMED4 25348397 N/A physical interaction ComPPI
SLC25A3 HSPA1L 25348397 N/A physical interaction ComPPI
SLC25A3 MRPS30 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFB8 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL10 25348397 N/A physical interaction ComPPI
SLC25A3 MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A3 MRPS26 25348397 N/A physical interaction ComPPI
SLC25A3 SFXN2 25348397 N/A physical interaction ComPPI
SLC25A3 SQOR 25348397 N/A physical interaction ComPPI
SLC25A3 MYL12A 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL30 25348397 N/A physical interaction ComPPI
SLC25A3 GPRC5A 25348397 N/A physical interaction ComPPI
SLC25A3 CLN3 25348397 N/A physical interaction ComPPI
SLC25A3 FBXO6 25348397 N/A physical interaction ComPPI
SLC25A3 ASB10 25348397 N/A physical interaction ComPPI
SLC25A3 ZBTB1 25348397 N/A physical interaction ComPPI
SLC25A3 LGR4 25348397 N/A physical interaction ComPPI
SLC25A3 MOV10 25348397 N/A physical interaction ComPPI
SLC25A3 NXF1 25348397 N/A physical interaction ComPPI
SLC25A3 CCDC8 25348397 N/A physical interaction ComPPI
SLC25A3 UNK 25348397 N/A physical interaction ComPPI
SLC25A3 AFG3L2 25348397 N/A physical interaction ComPPI
SLC25A3 ALDH3A2 25348397 N/A physical interaction ComPPI
SLC25A3 ATAD3A 25348397 N/A physical interaction ComPPI
SLC25A3 ATP5PB 25348397 N/A physical interaction ComPPI
SLC25A3 CCT3 25348397 N/A physical interaction ComPPI
SLC25A3 CCT6A 25348397 N/A physical interaction ComPPI
SLC25A3 HSD17B12 25348397 N/A physical interaction ComPPI
SLC25A3 MTCH1 25348397 N/A physical interaction ComPPI
SLC25A3 MTCH2 25348397 N/A physical interaction ComPPI
SLC25A3 MT-CO2 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFA12 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFB10 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFS1 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFS8 25348397 N/A physical interaction ComPPI
SLC25A3 SDHB 25348397 N/A physical interaction ComPPI
SLC25A3 CYC1 25348397 N/A physical interaction ComPPI
SLC25A3 TECR 25348397 N/A physical interaction ComPPI
SLC25A3 STOML2 25348397 N/A physical interaction ComPPI
SLC25A3 TMCO1 25348397 N/A physical interaction ComPPI
SLC25A3 UQCRQ 25348397 N/A physical interaction ComPPI
SLC25A3 VDAC3 25348397 N/A physical interaction ComPPI
SLC25A3 TUBA1C 25348397 N/A physical interaction ComPPI
SLC25A3 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A3 NDUFA4 25348397 N/A physical interaction ComPPI
SLC25A3 COQ9 25348397 N/A physical interaction ComPPI
SLC25A3 PTPMT1 25348397 N/A physical interaction ComPPI
SLC25A3 NMES1 25348397 N/A physical interaction ComPPI
SLC25A3 RC3H1 25348397 N/A physical interaction ComPPI
SLC25A3 ZNF746 25348397 N/A physical interaction ComPPI
SLC25A3 COX15 23260140 24234451 25348397 29128334 association cross-linking study,physical interaction,blue native page ComPPI,IntAct
SLC25A3 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC25A3 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC25A3 AGO3 19167051 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC25A3 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
SLC25A3 MEX3C 22863774 24234451 25348397 association pull down ComPPI,IntAct
SLC25A3 COA3 23260140 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC25A3 HTR7 19486527 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SLC25A3 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC25A3 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
SLC25A3 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC25A3 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ACADM SLC25A3 25348397 N/A physical interaction ComPPI
ILVBL SLC25A3 25348397 N/A physical interaction ComPPI
MRPL9 SLC25A3 25348397 N/A physical interaction ComPPI
DUX4 SLC25A3 24234451 25348397 26816005 association pull down ComPPI,IntAct
DHX15 SLC25A3 24234451 29021621 association anti tag coimmunoprecipitation IntAct
METTL14 SLC25A3 24234451 29507755 association anti tag coimmunoprecipitation IntAct
TOP1 SLC25A3 24234451 30021884 physical association cross-linking study IntAct
L1TD1 SLC25A3 24234451 25702638 association anti bait coimmunoprecipitation IntAct

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