GENE：SPATA5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SPATA5 |
| FullNmae | AFG2 AAA ATPase homolog A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18119 |
| EnsembleID | ENSG00000145375 |
| Uniprot | Q8NB90 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SPATA5 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SPATA5 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | SPATA5 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SPATA5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SPATA5 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | SPATA5 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SPATA5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000005D4F5 | SPATA5 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | SPATA5 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009C45F | SPATA5 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A122A | SPATA5 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000381CEC | SPATA5 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F0C23 | SPATA5 | 20371350 21572407 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000083D87 | SPATA5 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A8BC6 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032AE90 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DABC0 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002EF20A | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052EA98 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000007FBA | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FC26E | SPATA5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000939AF | SPATA5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002004E0 | SPATA5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | SPATA5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SNW1 | SPATA5 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDC5L | SPATA5 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PSMD14 | SPATA5 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NTRK1 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| PFDN5 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| ESR2 | SPATA5 | 24234451 25348397 25604459 | association | tandem affinity purification | ComPPI,IntAct |
| FAS | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| FBXW11 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| PFDN2 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| RCN2 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| AIFM1 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| ATAD3A | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |
| RIPK4 | SPATA5 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| C1ORF109 | SPATA5 | 25348397 | N/A | physical interaction | ComPPI |