GENE：SRP54
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SRP54 |
| FullNmae | signal recognition particle 54 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11301 |
| EnsembleID | ENSG00000100883 |
| Uniprot | P61011 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SRP54 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SRP54 | GO:0003723,GO:0003924,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005783,GO:0005786,GO:0005786,GO:0005829,GO:0005829,GO:0005829,GO:0006614,GO:0006616,GO:0006616,GO:0006617,GO:0008312,GO:0008312,GO:0016607,GO:0016887,GO:0019003,GO:0030593,GO:0030851,GO:0030942,GO:0030942,GO:0031017,GO:0043021,GO:0045047 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SRP54 | hsa:6729 | path:hsa03060 | Protein export - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SRP54 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SRP54 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SRP54 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SRP54 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | SRP54 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000BE495 | SRP54 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000049FAE8 | SRP54 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D5659 | SRP54 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000081E1F | SRP54 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C0099 | SRP54 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035D2F9 | SRP54 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SNW1 | SRP54 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDC5L | SRP54 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HSPA8 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SMN1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| DDX20 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| PRKDC | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SERPINA1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| TARBP2 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| GEMIN2 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| GEMIN5 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SOX2 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SF3A1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| MED23 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| STK4 | SRP54 | 23386615 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| DUSP22 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SRP14 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SRP9 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| DERL1 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| RNPS1 | SRP54 | 14525934 14729963 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| SMC4 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SF3B6 | SRP54 | 25348397 | N/A | physical interaction | ComPPI |
| SRP54 | XRCC4 | 25348397 | N/A | physical interaction | ComPPI |
| SRP54 | GEMIN4 | 25348397 | N/A | physical interaction | ComPPI |
| SRP54 | SMC2 | 25348397 | N/A | physical interaction | ComPPI |
| SRP54 | CCDC102B | 25348397 | N/A | physical interaction | ComPPI |
| SRP54 | MRPS11 | 25348397 | N/A | physical interaction | ComPPI |
| SRP54 | OTUB1 | 24234451 25348397 26752685 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| SRP54 | BCAR1 | 24234451 25348397 28007913 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| KHDRBS1 | SRP54 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| RPL3 | SRP54 | 21765803 27898060 | N/A | N/A | OmniPath |