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GENE：SMPD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMPD2
FullNmae sphingomyelin phosphodiesterase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11121
EnsembleID ENSG00000135587
Uniprot O60906

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMPD2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SMPD2 GO:0004767,GO:0004767,GO:0005515,GO:0005783,GO:0005886,GO:0005886,GO:0005901,GO:0006684,GO:0006685,GO:0008081,GO:0030149,GO:0046513,GO:0046872,GO:0071944

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMPD2 hsa:6610 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SMPD2 hsa:6610 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SMPD2 hsa:6610 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SMPD2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SMPD2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SMPD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMPD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SMPD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SMPD2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PIK3CG SMPD2 11238738 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARFIP1 SMPD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMPD2 HLA-DQA1 25348397 N/A physical interaction ComPPI
SMPD2 SRPRB 25348397 N/A physical interaction ComPPI
SMPD2 TMEM30A 25348397 N/A physical interaction ComPPI
SMPD2 KCNC4 25348397 N/A physical interaction ComPPI
SMPD2 RPN2 25348397 N/A physical interaction ComPPI
SMPD2 FAM189B 25348397 N/A physical interaction ComPPI
SMPD2 COQ8A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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