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GENE：SYMPK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SYMPK
FullNmae symplekin scaffold protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:22935
EnsembleID ENSG00000125755
Uniprot Q92797

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SYMPK cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SYMPK GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005847,GO:0005856,GO:0005886,GO:0005923,GO:0006378,GO:0007155,GO:0016604,GO:0032091,GO:0097165

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SYMPK hsa:8189 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)
SYMPK hsa:8189 path:hsa04530 Tight junction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SYMPK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SYMPK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SYMPK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SYMPK 19328795 trascriptional regulation,stimulation inferred by curator TFlink
MYC SYMPK N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000041FA2C SYMPK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000512C88 SYMPK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE SYMPK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 SYMPK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 SYMPK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 SYMPK 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SYMPK CPSF2 25361965 interaction type N/A PTMCode2
CPSF2 SYMPK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I SYMPK 25348397 N/A physical interaction ComPPI
SNW1 SYMPK 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC73 SYMPK 19136632 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L SYMPK 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAGEA6 SYMPK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VCP SYMPK 25348397 N/A physical interaction ComPPI
FOXB1 SYMPK 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
KEAP1 SYMPK 25348397 N/A physical interaction ComPPI
FIP1L1 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXG1 SYMPK 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK3 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN SYMPK 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
NTRK1 SYMPK 25348397 N/A physical interaction ComPPI
P4HB SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA1 SYMPK 25348397 N/A physical interaction ComPPI
CLK1 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 SYMPK 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RIN3 SYMPK 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RPA2 SYMPK 25348397 N/A physical interaction ComPPI
RPA3 SYMPK 25348397 N/A physical interaction ComPPI
PAPOLA SYMPK 18288197 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HTT SYMPK 14525934 25348397 9700202 N/A two hybrid,two hybrid ComPPI,HPRD
WWOX SYMPK 16055720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
RP2 SYMPK 25348397 N/A physical interaction ComPPI
FOXE1 SYMPK 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CSTF2 SYMPK 10669729 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CSTF3 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK HSF1 14525934 14707147 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
SYMPK SMARCAD1 25348397 N/A physical interaction ComPPI
SYMPK SIRT7 25348397 N/A physical interaction ComPPI
SYMPK TOP1 25348397 N/A physical interaction ComPPI
SYMPK CPSF3 18688255 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK CPSF2 18288197 18688255 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK SSU72 25348397 N/A molecular sieving,x-ray crystallography,physical interaction,physical interaction ComPPI
SYMPK KAT6A 25348397 N/A physical interaction ComPPI
SYMPK KMT2A 25348397 N/A physical interaction ComPPI
SYMPK BSG 25348397 N/A physical interaction ComPPI
SYMPK TMEM171 25348397 N/A physical interaction ComPPI
SYMPK LYPD3 25348397 N/A physical interaction ComPPI
SYMPK KLHDC3 25348397 N/A physical interaction ComPPI
SYMPK CPSF4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK KHSRP 25348397 N/A physical interaction ComPPI
SYMPK USP24 25348397 N/A physical interaction ComPPI
SYMPK WDR33 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK FN1 25348397 N/A physical interaction ComPPI
SYMPK VPS26A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK KLC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK ELMO3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK FOXH1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SYMPK FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SYMPK FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SYMPK FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SYMPK CPEB1 25348397 N/A physical interaction ComPPI
SYMPK SIGLECL1 25348397 N/A physical interaction ComPPI
SYMPK IL13RA2 25348397 N/A physical interaction ComPPI
SYMPK TUT1 18288197 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYMPK MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SYMPK GSTK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SYMPK PCBP2 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SYMPK CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
CPSF1 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSTF2T SYMPK 25348397 N/A physical interaction ComPPI
SYMPK CSTF2 10669729 21896654 26496610 27898060 stimulant N/A OmniPath
SYMPK CSTF1 10669729 27898060 stimulant N/A OmniPath

Visualization










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