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GENE：TAF4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TAF4
FullNmae TATA-box binding protein associated factor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11537
EnsembleID ENSG00000130699
Uniprot O00268

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TAF4 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TAF4 GO:0000785,GO:0001046,GO:0001541,GO:0001673,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005669,GO:0005669,GO:0005669,GO:0005829,GO:0006282,GO:0006352,GO:0006357,GO:0006366,GO:0006367,GO:0006367,GO:0016251,GO:0016251,GO:0017162,GO:0032991,GO:0033276,GO:0033276,GO:0042789,GO:0045893,GO:0046982,GO:0051123,GO:0060261,GO:0071339

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TAF4 hsa:6874 path:hsa03022 Basal transcription factors - Homo sapiens (human)
TAF4 hsa:6874 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JUN TAF4 20557936 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TAF4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 TAF4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TAF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREM TAF4 10409662 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 TAF4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006FDD4 TAF4 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KAT2A TAF4 25361965 interaction type N/A PTMCode2
TAF4 KAT2A 25361965 interaction type N/A PTMCode2
TAF4 TAF12 25361965 interaction type N/A PTMCode2
TAF12 TAF4 25361965 interaction type N/A PTMCode2
TAF4 TAF10 25361965 interaction type N/A PTMCode2
TAF10 TAF4 25361965 interaction type N/A PTMCode2
TAF4 TAF7 25361965 interaction type N/A PTMCode2
TAF7 TAF4 25361965 interaction type N/A PTMCode2
TAF4 ATF7 25361965 interaction type N/A PTMCode2
ATF7 TAF4 25361965 interaction type N/A PTMCode2
TAF4 TAF13 25361965 interaction type N/A PTMCode2
TAF13 TAF4 25361965 interaction type N/A PTMCode2
TAF4 TAF5 25361965 interaction type N/A PTMCode2
TAF5 TAF4 25361965 interaction type N/A PTMCode2
TAF4 TAF8 25361965 interaction type N/A PTMCode2
TAF8 TAF4 25361965 interaction type N/A PTMCode2
TAF4 TAF2 25361965 interaction type N/A PTMCode2
TAF2 TAF4 25361965 interaction type N/A PTMCode2
TAF4 GTF2A2 25361965 interaction type N/A PTMCode2
GTF2A2 TAF4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TAF12 TAF4 12237304 14525934 14580349 24234451 25348397 N/A cosedimentation through density gradient,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,ion exchange chromatography,in vitro,in vivo ComPPI,HPRD,IntAct
TAF9 TAF4 14525934 14580349 23292512 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GTF2A1 TAF4 11564872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2A2 TAF4 11564872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CREBZF TAF4 17483474 24234451 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI,IntAct
TAF9B TAF4 25348397 N/A physical interaction ComPPI
SP1 TAF4 11988536 14525934 25348397 27898060 9742090 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
TBP TAF4 10373431 24234451 25348397 9603525 9674425 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN TAF4 20557936 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GTF2F2 TAF4 25348397 N/A physical interaction ComPPI
TAF1 TAF4 11564872 14525934 14580349 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDC16 TAF4 25348397 N/A physical interaction ComPPI
KIFAP3 TAF4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPL TAF4 25348397 N/A physical interaction ComPPI
EWSR1 TAF4 25348397 N/A physical interaction ComPPI
AHR TAF4 14525934 15641800 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TAF11 TAF4 14525934 14580349 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBX5 TAF4 11959914 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
H3-4 TAF4 25348397 N/A physical interaction ComPPI
EGFR TAF4 25348397 N/A physical interaction ComPPI
HTT TAF4 11988536 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
TAF4 TAF2 14525934 14580349 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TAF4 TAF7 14525934 14580349 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TAF4 TAF6 14525934 14580349 23292512 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TAF4 TAF5 14525934 14580349 23292512 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TAF4 TAF10 14525934 14580349 23292512 24234451 25348397 9603525 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TAF4 TAF8 14525934 14580349 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD
TAF4 ATF7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
TAF4 CREM 10409662 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TAF4 KAT2A 10373431 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
TAF4 SUPT3H 25348397 N/A physical interaction ComPPI
TAF4 AK6 25348397 N/A physical interaction ComPPI
TAF4 CREB1 25348397 N/A physical interaction ComPPI
TAF4 TCF12 25348397 N/A physical interaction ComPPI
TAF4 ELAVL1 25348397 N/A physical interaction ComPPI
TAF4 TRRAP 18418385 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TAF4 TAF3 25348397 N/A physical interaction ComPPI
TAF4 TAF1L 25348397 N/A physical interaction ComPPI
TAF4 MED26 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAF4 FBXO6 25348397 N/A physical interaction ComPPI
TAF4 SOX6 25348397 N/A physical interaction ComPPI
TAF4 NUP50 25348397 N/A physical interaction ComPPI
TAF4 ANAPC1 25348397 N/A physical interaction ComPPI
TAF4 ANAPC7 25348397 N/A physical interaction ComPPI
TAF4 NAP1L4 25348397 N/A physical interaction ComPPI
TAF4 CDC23 25348397 N/A physical interaction ComPPI
TAF4 CDC27 25348397 N/A physical interaction ComPPI
TAF4 NCL 25348397 N/A physical interaction ComPPI
TAF4 SF3B3 25348397 N/A physical interaction ComPPI
TAF4 TAF7L 25348397 N/A physical interaction ComPPI
TAF4 TCF3 17483474 24234451 25348397 N/A isothermal titration calorimetry,physical interaction ComPPI,IntAct
TAF4 CREB3 17483474 24234451 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI,IntAct
TAF4 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TAF4 CDK7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H3C1 TAF4 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TAF13 TAF4 25348397 N/A physical interaction ComPPI
TBPL1 TAF4 25348397 N/A physical interaction ComPPI
WDR5 TAF4 15960975 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ANAPC13 TAF4 25348397 N/A physical interaction ComPPI
PYGO TAF4 19116271 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
CBX3 TAF4 11959914 14525934 N/A experimental interaction detection,two hybrid HPRD
TAF4 TERF2IP 20189987 23814059 25800674 27898060 N/A N/A OmniPath
JUN TAF4 20557936 27898060 N/A N/A OmniPath

Visualization










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