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GENE：TARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TARS2
FullNmae threonyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30740
EnsembleID ENSG00000143374
Uniprot Q9BW92

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TARS2 GO:0002161,GO:0004829,GO:0004829,GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0006435,GO:0042803,GO:0070159,GO:0106074

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TARS2 hsa:80222 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 TARS2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE TARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000032835F TARS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000753AD TARS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000013ABA3 TARS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000411752 TARS2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004CCA62 TARS2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KEAP1 TARS2 25348397 N/A physical interaction ComPPI
PTPN18 TARS2 25348397 N/A physical interaction ComPPI
PPP1R15A TARS2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN TARS2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 TARS2 25348397 N/A physical interaction ComPPI
NTRK1 TARS2 25348397 N/A physical interaction ComPPI
HNRNPL TARS2 25348397 N/A physical interaction ComPPI
CFTR TARS2 25348397 N/A physical interaction ComPPI
EGFR TARS2 25348397 N/A physical interaction ComPPI
PLIN3 TARS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDK1 TARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDC37 TARS2 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4A2 TARS2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TNFRSF10D TARS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPD1 TARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ASB6 TARS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AHSA1 TARS2 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX6B1 TARS2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct

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