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GENE：MAP3K6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K6
FullNmae mitogen-activated protein kinase kinase kinase 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6858
EnsembleID ENSG00000142733
Uniprot O95382

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K6 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K6 GO:0000165,GO:0000287,GO:0004709,GO:0004709,GO:0005524,GO:0006468,GO:0007165,GO:0033554,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K6 hsa:9064 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YWHAB MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
YWHAE MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
YWHAG MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
YWHAH MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
YWHAQ MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
YWHAZ MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
SFN MAP3K6 19935702 23180781 physical association affinity chromatography technology InnateDB
MAP3K5 MAP3K6 19935702 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K6 MAP2K4 23331499 9875215 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP3K6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 MAP3K6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP3K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP3K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP3K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP3K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MAP3K6 MAPK8 22135298 phosphorylation N/A PhosphoSite
MAP3K6 MAP3K6 22135298 phosphorylation N/A PhosphoSite
MAP3K6 MAPK14 22135298 phosphorylation N/A PhosphoSite
MAP3K6 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 MAP3K6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 MAP3K6 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAG MAP3K6 19935702 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
HSP90AB1 MAP3K6 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSP90AA1 MAP3K6 25348397 N/A physical interaction ComPPI
XRCC5 MAP3K6 25348397 N/A physical interaction ComPPI
MAP3K5 MAP3K6 14525934 17210579 24234451 25348397 25852190 9875215 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RNF123 MAP3K6 25348397 N/A physical interaction ComPPI
UBAC1 MAP3K6 25348397 N/A physical interaction ComPPI
USP4 MAP3K6 25348397 N/A physical interaction ComPPI
TNFSF13B MAP3K6 25348397 N/A physical interaction ComPPI
CDC37 MAP3K6 25348397 N/A physical interaction ComPPI
PCDHA4 MAP3K6 25348397 N/A physical interaction ComPPI
ASPM MAP3K6 25348397 N/A physical interaction ComPPI
MAP3K6 PRKAB2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K6 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP3K6 SHMT2 25348397 N/A physical interaction ComPPI
MAP3K6 PLEKHO2 25348397 N/A physical interaction ComPPI
MAP3K6 FKBP5 25348397 N/A physical interaction ComPPI
MAP3K6 LIMD1 25348397 N/A physical interaction ComPPI
MAP3K6 ERGIC2 25348397 N/A physical interaction ComPPI
MAP3K6 MAP3K6 14525934 17210579 N/A experimental interaction detection HPRD
MAP3K6 YWHAG 19935702 27898060 N/A N/A OmniPath
MAP3K6 MAP2K4 27898060 9875215 stimulant N/A OmniPath
MAP3K6 MAP3K5 11689443 17210579 19935702 25852190 27898060 9875215 stimulant N/A OmniPath
MAP3K5 MAP3K6 11689443 17210579 19935702 25852190 27898060 9875215 N/A N/A OmniPath
MAP3K6 YWHAZ 19935702 27898060 N/A N/A OmniPath
MAP3K6 SFN 19935702 27898060 N/A N/A OmniPath
MAP3K6 YWHAQ 19935702 27898060 N/A N/A OmniPath
MAP3K6 YWHAE 19935702 27898060 N/A N/A OmniPath
MAP3K6 YWHAB 19935702 27898060 N/A N/A OmniPath
MAP3K6 YWHAH 19935702 27898060 N/A N/A OmniPath

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