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GENE：TFAM

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TFAM
FullNmae transcription factor A, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11741
EnsembleID ENSG00000108064
Uniprot Q00059

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TFAM cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TFAM GO:0000976,GO:0001018,GO:0001223,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005759,GO:0005759,GO:0005829,GO:0006390,GO:0006391,GO:0006391,GO:0031072,GO:0032991,GO:0033108,GO:0034246,GO:0042645,GO:0043565,GO:0045893

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TFAM hsa:7019 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
TFAM hsa:7019 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TFAM CAV1 22129993 26192618 interaction type N/A ACSN
SUZ12 TFAM 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TFAM 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TFAM 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TFAM 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TFAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC TFAM 15988031 trascriptional regulation,stimulation inferred by curator TFlink
MYB TFAM N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171CD1 TFAM 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE TFAM 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 TFAM 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000008DA94 TFAM 24684598 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000535FDD TFAM 23047984 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000306C70 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 TFAM 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B TFAM 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE TFAM 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A TFAM 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000034B6F5 TFAM 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000C7662 TFAM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 TFAM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 TFAM 25416803 25869329 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000215483 TFAM 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA TFAM 22135298 phosphorylation N/A PhosphoSite
CDK2 TFAM 22135298 phosphorylation N/A PhosphoSite
TFB1M TFAM 25361965 interaction type N/A PTMCode2
TFAM TFB1M 25361965 interaction type N/A PTMCode2
TFAM TFAM 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPP2R1A TFAM 25348397 N/A physical interaction ComPPI
LMNA TFAM 24234451 25348397 29568061 association pull down ComPPI,IntAct
JUN TFAM 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 TFAM 25348397 N/A physical interaction ComPPI
CUL3 TFAM 25348397 N/A physical interaction ComPPI
RPA1 TFAM 25348397 N/A physical interaction ComPPI
MYC TFAM 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
C1QBP TFAM 25348397 N/A physical interaction ComPPI
AGTRAP TFAM 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NFATC2 TFAM 25348397 N/A physical interaction ComPPI
TNIK TFAM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ABCE1 TFAM 25348397 N/A physical interaction ComPPI
STATH TFAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAB11A TFAM 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDC14B TFAM 25348397 N/A physical interaction ComPPI
VCAM1 TFAM 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
EED TFAM 25348397 N/A physical interaction ComPPI
CUL7 TFAM 25348397 N/A physical interaction ComPPI
CAND1 TFAM 25348397 N/A physical interaction ComPPI
NFKB1 TFAM 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
TFB1M TFAM 12068295 12897151 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo,immunodepleted coimmunoprecipitation ComPPI,HPRD,IntAct
TFAM TFB2M 12068295 12897151 14525934 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
TFAM MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFAM ELAVL1 25348397 N/A physical interaction ComPPI
TFAM FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TFAM PAN2 25348397 N/A physical interaction ComPPI
TFAM GRSF1 25348397 N/A physical interaction ComPPI
TFAM NEDD1 25348397 N/A physical interaction ComPPI
TFAM FBXW11 25348397 N/A physical interaction ComPPI
TFAM ARL6IP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFAM SUZ12 25348397 N/A physical interaction ComPPI
TFAM KCTD17 25348397 N/A physical interaction ComPPI
TFAM RPS6KB2 25348397 N/A physical interaction ComPPI
TFAM GOPC 25348397 N/A physical interaction ComPPI
TFAM CYLD 25348397 N/A physical interaction ComPPI
TFAM SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TFAM ZUP1 25348397 N/A physical interaction ComPPI
TFAM MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TFAM IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TFAM PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
TFAM CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
TFAM TSPAN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFAM TECR 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFAM BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
TFAM PPM1G 24234451 25348397 28330616 association pull down ComPPI,IntAct
TFAM BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TFAM HSPD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TFAM SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AURKAIP1 TFAM 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PNP TFAM 12068295 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MGST3 TFAM 24234451 25348397 29568061 association,physical association two hybrid,two hybrid array,two hybrid prey pooling approach,proximity-dependent biotin identification ComPPI,IntAct
TRMT61B TFAM 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB TFAM 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
WTAP TFAM 24234451 29507755 association anti tag coimmunoprecipitation IntAct
SMARCB1 TFAM 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
STK38L TFAM 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
TFAM ACOT2 24234451 30021884 physical association cross-linking study IntAct
PRKACA TFAM 23201127 27898060 stimulant N/A OmniPath
NRF1 TFAM 16230352 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009ACF73 TFAM 27087310 direct interaction,inhibition N/A NPInter

Visualization










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