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GENE：TKT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TKT
FullNmae transketolase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11834
EnsembleID ENSG00000163931
Uniprot P29401

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TKT cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TKT GO:0000287,GO:0004802,GO:0004802,GO:0005509,GO:0005515,GO:0005654,GO:0005777,GO:0005789,GO:0005829,GO:0006098,GO:0009052,GO:0009052,GO:0016604,GO:0030976,GO:0031982,GO:0040008,GO:0042803,GO:0046166,GO:0070062,GO:1901159

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TKT hsa:7086 path:hsa00030 Pentose phosphate pathway - Homo sapiens (human)
TKT hsa:7086 path:hsa01100 Metabolic pathways - Homo sapiens (human)
TKT hsa:7086 path:hsa01200 Carbon metabolism - Homo sapiens (human)
TKT hsa:7086 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MLX TKT 11557773 11744734 14672622 15199147 16782875 17143338 18458340 26192618 8955077 9192621 interaction type N/A ACSN
MLXIP TKT 11557773 11744734 14672622 15199147 16782875 17143338 18458340 26192618 8955077 9192621 interaction type N/A ACSN
TKT SQSTM1 14702098 23180781 physical association pull down InnateDB
ISG15 TKT 16009940 23180781 physical association unspecified method InnateDB
TKT UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR TKT 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TKT 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TKT 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC TKT 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TFAP2C TKT 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TKT 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 TKT 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE TKT 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC TKT 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D TKT 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000034B6F5 TKT 23921124 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
AKT1 TKT 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I TKT 25348397 N/A physical interaction ComPPI
MOCOS TKT 25348397 N/A physical interaction ComPPI
EIF1B TKT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ZNRD2 TKT 25348397 N/A physical interaction ComPPI
LDHB TKT 25348397 N/A physical interaction ComPPI
LDHA TKT 25348397 N/A physical interaction ComPPI
ISG15 TKT 25348397 N/A physical interaction ComPPI
PCBP1 TKT 25348397 N/A physical interaction ComPPI
CFL1 TKT 25348397 N/A physical interaction ComPPI
RPIA TKT 25348397 N/A physical interaction ComPPI
VCP TKT 25348397 N/A physical interaction ComPPI
GABARAPL2 TKT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM32 TKT 25348397 N/A physical interaction ComPPI
UBE2D1 TKT 25348397 N/A physical interaction ComPPI
COTL1 TKT 25348397 N/A physical interaction ComPPI
MCM2 TKT 25348397 N/A physical interaction ComPPI
RAB10 TKT 25348397 N/A physical interaction ComPPI
COX17 TKT 25348397 N/A physical interaction ComPPI
MAPK8 TKT 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCD TKT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN TKT 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
STAT4 TKT 25348397 N/A physical interaction ComPPI
U2AF2 TKT 25348397 N/A physical interaction ComPPI
VAPA TKT 25348397 N/A physical interaction ComPPI
CUL3 TKT 25348397 N/A physical interaction ComPPI
DYNC1LI1 TKT 25348397 N/A physical interaction ComPPI
DUT TKT 25348397 N/A physical interaction ComPPI
SCYL2 TKT 25348397 N/A physical interaction ComPPI
GAPDH TKT 25348397 N/A physical interaction ComPPI
YWHAZ TKT 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
NTRK1 TKT 25348397 N/A physical interaction ComPPI
ENO1 TKT 25348397 N/A physical interaction ComPPI
PIR TKT 25348397 N/A physical interaction ComPPI
CALR TKT 25348397 N/A physical interaction ComPPI
STIP1 TKT 25348397 N/A physical interaction ComPPI
P4HB TKT 25348397 N/A physical interaction ComPPI
PRDX1 TKT 25348397 N/A physical interaction ComPPI
PTGES3 TKT 25348397 N/A physical interaction ComPPI
MYC TKT 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PLEC TKT 25348397 N/A physical interaction ComPPI
GLRX TKT 25348397 N/A physical interaction ComPPI
XRCC6 TKT 25348397 N/A physical interaction ComPPI
TUBA4A TKT 25348397 N/A physical interaction ComPPI
CFTR TKT 25348397 N/A physical interaction ComPPI
FSCN1 TKT 25348397 N/A physical interaction ComPPI
VDAC1 TKT 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SQSTM1 TKT 25348397 N/A physical interaction ComPPI
AKR1B1 TKT 25348397 N/A physical interaction ComPPI
PKM TKT 25348397 N/A physical interaction ComPPI
RDX TKT 25348397 N/A physical interaction ComPPI
GOLGA4 TKT 25348397 N/A physical interaction ComPPI
RPE TKT 25348397 N/A physical interaction ComPPI
SRI TKT 25348397 N/A physical interaction ComPPI
NEDD8 TKT 25348397 N/A physical interaction ComPPI
SPR TKT 25348397 N/A physical interaction ComPPI
TPI1 TKT 25348397 N/A physical interaction ComPPI
CDK2 TKT 25348397 N/A physical interaction ComPPI
ACAA2 TKT 25348397 N/A physical interaction ComPPI
HTT TKT 25348397 N/A physical interaction ComPPI
VHL TKT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HSPB1 TKT 25348397 N/A physical interaction ComPPI
HSPA9 TKT 25348397 N/A physical interaction ComPPI
MED17 TKT 25348397 N/A physical interaction ComPPI
SF1 TKT 25348397 N/A physical interaction ComPPI
MSN TKT 25348397 N/A physical interaction ComPPI
DNM1L TKT 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IGBP1 TKT 25348397 N/A physical interaction ComPPI
TBL1X TKT 25348397 N/A physical interaction ComPPI
HDAC5 TKT 25348397 N/A physical interaction ComPPI
BCOR TKT 25348397 N/A physical interaction ComPPI
PDCD6 TKT 25348397 N/A physical interaction ComPPI
ASS1 TKT 25348397 N/A physical interaction ComPPI
PGK1 TKT 25348397 N/A physical interaction ComPPI
PCMT1 TKT 25348397 N/A physical interaction ComPPI
HSPE1 TKT 25348397 N/A physical interaction ComPPI
CAMK2B TKT 25348397 N/A physical interaction ComPPI
FABP5 TKT 25348397 N/A physical interaction ComPPI
WDR1 TKT 25348397 N/A physical interaction ComPPI
H2AX TKT 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TERF1 TKT 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PDCD6IP TKT 25348397 N/A physical interaction ComPPI
BRCA1 TKT 25348397 N/A physical interaction ComPPI
MYOC TKT 14525934 16289162 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TALDO1 TKT 25348397 N/A physical interaction ComPPI
SOD1 TKT 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EXOSC9 TKT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF10D TKT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IKBKE TKT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TBC1D4 TKT 25348397 N/A physical interaction ComPPI
IFI16 TKT 25348397 N/A physical interaction ComPPI
GPI TKT 25348397 N/A physical interaction ComPPI
TES TKT 25348397 N/A physical interaction ComPPI
SPC25 TKT 25348397 N/A physical interaction ComPPI
MED20 TKT 25348397 N/A physical interaction ComPPI
DAZAP1 TKT 25348397 N/A physical interaction ComPPI
YKT6 TKT 25348397 N/A physical interaction ComPPI
EZR TKT 25348397 N/A physical interaction ComPPI
POLA2 TKT 25348397 N/A physical interaction ComPPI
RSU1 TKT 25348397 N/A physical interaction ComPPI
EIF2AK4 TKT 25348397 N/A physical interaction ComPPI
AK2 TKT 25348397 N/A physical interaction ComPPI
FUS TKT 25348397 N/A physical interaction ComPPI
HSD17B10 TKT 25348397 N/A physical interaction ComPPI
MIF TKT 25348397 N/A physical interaction ComPPI
HINT1 TKT 25348397 N/A physical interaction ComPPI
TKT ATG5 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TKT PIK3C2A 25348397 N/A physical interaction ComPPI
TKT AHCYL1 25348397 N/A physical interaction ComPPI
TKT UFC1 25348397 N/A physical interaction ComPPI
TKT VDAC3 25348397 N/A physical interaction ComPPI
TKT UGDH 25348397 N/A physical interaction ComPPI
TKT UFM1 25348397 N/A physical interaction ComPPI
TKT FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TKT FBXO6 25348397 N/A physical interaction ComPPI
TKT ACP1 25348397 N/A physical interaction ComPPI
TKT AKR1A1 25348397 N/A physical interaction ComPPI
TKT AKR1B15 25348397 N/A physical interaction ComPPI
TKT AKR1C2 25348397 N/A physical interaction ComPPI
TKT ALDH4A1 25348397 N/A physical interaction ComPPI
TKT ALDOA 25348397 N/A physical interaction ComPPI
TKT ENO2 25348397 N/A physical interaction ComPPI
TKT ENO3 25348397 N/A physical interaction ComPPI
TKT FABP5P3 25348397 N/A physical interaction ComPPI
TKT FABP7 25348397 N/A physical interaction ComPPI
TKT FH 25348397 N/A physical interaction ComPPI
TKT GPX4 25348397 N/A physical interaction ComPPI
TKT HSPA4L 25348397 N/A physical interaction ComPPI
TKT IDH1 25348397 N/A physical interaction ComPPI
TKT ITPA 25348397 N/A physical interaction ComPPI
TKT LDHAL6B 25348397 N/A physical interaction ComPPI
TKT LYPLA2 25348397 N/A physical interaction ComPPI
TKT NANS 25348397 N/A physical interaction ComPPI
TKT NME2 25348397 N/A physical interaction ComPPI
TKT PGM2 25348397 N/A physical interaction ComPPI
TKT PITPNB 25348397 N/A physical interaction ComPPI
TKT PLS3 25348397 N/A physical interaction ComPPI
TKT ABHD14B 25348397 N/A physical interaction ComPPI
TKT ANXA7 25348397 N/A physical interaction ComPPI
TKT C11ORF54 25348397 N/A physical interaction ComPPI
TKT CAPG 25348397 N/A physical interaction ComPPI
TKT FKBP7 25348397 N/A physical interaction ComPPI
TKT GLO1 25348397 N/A physical interaction ComPPI
TKT GLOD4 25348397 N/A physical interaction ComPPI
TKT LAP3 25348397 N/A physical interaction ComPPI
TKT PAICS 25348397 N/A physical interaction ComPPI
TKT SLC2A9 25348397 N/A physical interaction ComPPI
TKT TAGLN2 25348397 N/A physical interaction ComPPI
TKT TAGLN3 25348397 N/A physical interaction ComPPI
TKT TIGAR 25348397 N/A physical interaction ComPPI
TKT PPME1 25348397 N/A physical interaction ComPPI
TKT SERPINB5 25348397 N/A physical interaction ComPPI
TKT KHNYN 25348397 N/A physical interaction ComPPI
TKT GREB1 25348397 N/A physical interaction ComPPI
TKT SMG8 25348397 N/A physical interaction ComPPI
TKT DMWD 25348397 N/A physical interaction ComPPI
TKT ATG2B 25348397 N/A physical interaction ComPPI
TKT FIGNL1 25348397 N/A physical interaction ComPPI
TKT WDR54 25348397 N/A physical interaction ComPPI
TKT C5ORF34 25348397 N/A physical interaction ComPPI
TKT WDR19 25348397 N/A physical interaction ComPPI
TKT POTEF 25348397 N/A physical interaction ComPPI
TKT WDR41 25348397 N/A physical interaction ComPPI
TKT STIL 25348397 N/A physical interaction ComPPI
TKT KDM5C 25348397 N/A physical interaction ComPPI
TKT LCMT2 25348397 N/A physical interaction ComPPI
TKT DPP9 25348397 N/A physical interaction ComPPI
TKT EML4 25348397 N/A physical interaction ComPPI
TKT TRAPPC8 25348397 N/A physical interaction ComPPI
TKT AASDH 25348397 N/A physical interaction ComPPI
TKT SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TKT SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TKT FTSJ1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TKT FBXO11 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TKT MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TKT HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TKT ACTR6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TKT ITGB1BP2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TKT BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
TKT PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
TKT COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
SOD2 TKT 25348397 N/A physical interaction ComPPI
GH1 TKT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CALU TKT 25348397 N/A physical interaction ComPPI
ESD TKT 25348397 N/A physical interaction ComPPI
PMP2 TKT 25348397 N/A physical interaction ComPPI
TKT TKT 14525934 9357955 N/A experimental interaction detection HPRD
SMARCB1 TKT 24234451 30108113 association proximity-dependent biotin identification IntAct
ISG15 TKT 16009940 27898060 N/A N/A OmniPath

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