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GENE：TOP1MT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TOP1MT
FullNmae DNA topoisomerase I mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29787
EnsembleID ENSG00000184428
Uniprot Q969P6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TOP1MT cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TOP1MT GO:0003677,GO:0003917,GO:0005654,GO:0005694,GO:0005739,GO:0006260,GO:0006265,GO:0042645,GO:0042645

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 TOP1MT 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TOP1MT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC TOP1MT 21531700 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000077AED TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000157F5 TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000171FEC TOP1MT 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MCM5 TOP1MT 25348397 N/A physical interaction ComPPI
CDK2 TOP1MT 25348397 N/A physical interaction ComPPI
PRPS1 TOP1MT 25348397 N/A physical interaction ComPPI
TFG TOP1MT 25348397 N/A physical interaction ComPPI
LEO1 TOP1MT 25348397 N/A physical interaction ComPPI
TP53 TOP1MT 24234451 25348397 25402006 physical association pull down,physical interaction ComPPI,IntAct
NIBAN1 TOP1MT 10921873 22863883 22939629 26344197 28514442 30476227 9751720 colocalization,physical association affinity chromatography technology,two hybrid,pull down,biochemical TheBiogrid
TOP1MT WFIKKN1 22863883 30476227 colocalization biochemical TheBiogrid

Visualization










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