GENE：TPK1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TPK1 |
| FullNmae | thiamin pyrophosphokinase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17358 |
| EnsembleID | ENSG00000196511 |
| Uniprot | Q9H3S4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TPK1 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TPK1 | GO:0004788,GO:0004788,GO:0005515,GO:0005524,GO:0005829,GO:0006772,GO:0009229,GO:0009229,GO:0009229,GO:0016301,GO:0016310,GO:0030975,GO:0042802 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TPK1 | hsa:27010 | path:hsa00730 | Thiamine metabolism - Homo sapiens (human) |
| TPK1 | hsa:27010 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| TPK1 | hsa:27010 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | TPK1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | TPK1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | TPK1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | TPK1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TPK1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | TPK1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | TPK1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | TPK1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | TPK1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TPK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000DDD35 | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012930C | TPK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PARP2 | TPK1 | 21812934 24234451 25348397 | adp ribosylation reaction | protein array | ComPPI,IntAct |
| TOMM70 | TPK1 | 21215441 22419819 27898060 | N/A | N/A | OmniPath |
| PTK2B | TPK1 | 12063246 20639203 27898060 | N/A | N/A | OmniPath |
| RASGRF1 | TPK1 | 16751660 19364808 21457714 27898060 | N/A | N/A | OmniPath |
| TPK1 | TOMM22 | 21215441 24093680 27898060 | N/A | N/A | OmniPath |