GENE:TUT1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TUT1 |
| FullNmae | terminal uridylyl transferase 1, U6 snRNA-specific |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:26184 |
| EnsembleID | ENSG00000149016 |
| Uniprot | Q9H6E5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TUT1 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TUT1 | GO:0003723,GO:0003730,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0006378,GO:0006378,GO:0006378,GO:0016180,GO:0016607,GO:0016607,GO:0017070,GO:0019899,GO:0034477,GO:0046872,GO:0050265,GO:0140767,GO:1990817,GO:1990817 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | TUT1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | TUT1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | TUT1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TUT1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TUT1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | TUT1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | TUT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TUT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | TUT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TUT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | TUT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000FC8EB | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000048F59D | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000DDD35 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000035CC3E | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000F6E49 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000AA464 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000005481D | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001597DC | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000148B91 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000367985 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000345DEB | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002075FA | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000031E12 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | TUT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIN1 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| SNRPF | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| SNRPG | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| LSM6 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| HMOX1 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| KATNBL1 | TUT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| YWHAZ | TUT1 | 20618440 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| YWHAQ | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| USP4 | TUT1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HUWE1 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| SOX2 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| CDC37 | TUT1 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| SART3 | TUT1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LSM5 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| CSTF2 | TUT1 | 18288197 21102410 24234451 25348397 | association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| SYMPK | TUT1 | 18288197 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PIP5K1A | TUT1 | 18288197 24234451 25348397 27898060 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction | ComPPI,IntAct,OmniPath |
| PRPF4 | TUT1 | 19615732 24234451 25348397 26496610 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TIMELESS | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| CPSF4 | TUT1 | 21102410 24234451 25348397 | association | pull down | ComPPI,IntAct |
| CPSF1 | TUT1 | 21102410 24234451 25348397 | association | anti bait coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| CPSF2 | TUT1 | 18288197 21102410 24234451 25348397 | association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| CPSF3 | TUT1 | 18288197 21102410 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| PRPF3 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| SNRPE | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| SNRPN | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| IL32 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO6 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| SNRPGP15 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| USP15 | TUT1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRPF31 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| YTHDF1 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| MEPCE | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| TUT1 | CENATAC | 25348397 | N/A | physical interaction | ComPPI |
| TUT1 | LARP7 | 18281698 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| FGL1 | TUT1 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK1A1 | TUT1 | 26138484 27898060 | N/A | N/A | OmniPath |
