Gene Information gene info

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GENE：TWNK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TWNK
FullNmae twinkle mtDNA helicase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1160
EnsembleID ENSG00000107815
Uniprot Q96RR1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TWNK cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TWNK GO:0002020,GO:0003678,GO:0003697,GO:0003697,GO:0005524,GO:0005739,GO:0005759,GO:0006264,GO:0006264,GO:0006264,GO:0006268,GO:0006390,GO:0016887,GO:0034214,GO:0042645,GO:0042802,GO:0043139,GO:0071333

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TWNK hsa:56652 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTCF TWNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TWNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TWNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000345DEB TWNK 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000122ED0 TWNK 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005CE113 TWNK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 TWNK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 TWNK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F TWNK 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BMI1 TWNK 25348397 N/A physical interaction ComPPI
NCOA5 TWNK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD9 TWNK 25348397 N/A two hybrid,physical interaction ComPPI
RAD9A TWNK 25348397 N/A physical interaction ComPPI
SQSTM1 TWNK 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUMO2 TWNK 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
YWHAH TWNK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MECP2 TWNK 25348397 N/A physical interaction ComPPI
RBMX TWNK 25348397 N/A physical interaction ComPPI
TRIM27 TWNK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HEXIM1 TWNK 25348397 N/A physical interaction ComPPI
FOXP1 TWNK 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TRA2A TWNK 25348397 N/A physical interaction ComPPI
AKTIP TWNK 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CLTA TWNK 25348397 N/A physical interaction ComPPI
CDX1 TWNK 25348397 N/A physical interaction ComPPI
LGALS3BP TWNK 25348397 N/A physical interaction ComPPI
TWNK TPM1 25348397 N/A physical interaction ComPPI
TWNK DCAF8 25348397 N/A physical interaction ComPPI
TWNK EPB41L5 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
TWNK ZC3H18 25348397 N/A physical interaction ComPPI
TWNK TP53 22653443 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct

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