Gene Information gene info

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GENE：TYR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TYR
FullNmae tyrosinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12442
EnsembleID ENSG00000077498
Uniprot P14679

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TYR cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
TYR cuproptosis 38348451 Tyrosinase. Involved in melanin synthesis. Its role in cuproptosis may involve pigment-related processes. CRGs in the cuproptosis pathway
TYR cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
TYR cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
TYR GO:0004503,GO:0004503,GO:0005507,GO:0005515,GO:0005737,GO:0005764,GO:0005798,GO:0006583,GO:0006726,GO:0007601,GO:0008283,GO:0009411,GO:0009637,GO:0033162,GO:0033280,GO:0042438,GO:0042438,GO:0042470,GO:0042802,GO:0042803,GO:0043231,GO:0043473,GO:0048471,GO:0048538,GO:0051591

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TYR hsa:7299 path:hsa00350 Tyrosine metabolism - Homo sapiens (human)
TYR hsa:7299 path:hsa01100 Metabolic pathways - Homo sapiens (human)
TYR hsa:7299 path:hsa04916 Melanogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTNNB1 TYR 17000761 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
MITF TYR 10080955 10587587 12034359 12136092 18424413 18971253 21910056 22259223 23872139 9158138 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TYR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TYR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
OTX2 TYR 22259223 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 TYR 17702866 trascriptional regulation,stimulation inferred by curator TFlink
TFEB TYR 10707962 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TYR N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 TYR N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000007A060 TYR 25416803 27363653 mrna cleavage,inhibition western blot TarBase

Source Target Pmid Interactiontype Methods Database
PRKCB TYR 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SYVN1 TYR 25348397 N/A physical interaction ComPPI
TYRP1 TYR 14525934 14623273 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCB TYR 10347209 27898060 stimulant N/A OmniPath
TYR NFKBIA 27898060 8797825 N/A N/A OmniPath

Visualization










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