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GENE：MAPKAPK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAPKAPK3
FullNmae MAPK activated protein kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6888
EnsembleID ENSG00000114738
Uniprot Q16644

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAPKAPK3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPKAPK3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAPKAPK3 GO:0000165,GO:0002224,GO:0002224,GO:0004674,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0009931,GO:0018105,GO:0018105,GO:0032496,GO:0034097,GO:0034097,GO:0035556,GO:0044351,GO:0046777,GO:0048010,GO:0051019,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAPKAPK3 hsa:7867 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAPKAPK3 hsa:7867 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPKAPK3 MAPK14 10581204 11157753 23180781 8626550 phosphorylation reaction,physical association anti tag coimmunoprecipitation,two hybrid,gst pull down,pull down,in-gel kinase assay InnateDB
MAPK14 MAPKAPK3 11157753 21071413 23331499 9922370 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAPKAPK3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAPKAPK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAPKAPK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 MAPKAPK3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MAPKAPK3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MAPKAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB5 MAPKAPK3 21132541 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MAPKAPK3 BECN1 22135298 phosphorylation N/A PhosphoSite
HSPB1 MAPKAPK3 25361965 interaction type N/A PTMCode2
MAPKAPK3 HSPB1 25361965 interaction type N/A PTMCode2
MAPK13 MAPKAPK3 25361965 interaction type N/A PTMCode2
MAPKAPK3 MAPK13 25361965 interaction type N/A PTMCode2
TCF3 MAPKAPK3 25361965 interaction type N/A PTMCode2
MAPKAPK3 TCF3 25361965 interaction type N/A PTMCode2
MAPK14 MAPKAPK3 25361965 interaction type N/A PTMCode2
MAPKAPK3 MAPK14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BMI1 MAPKAPK3 25348397 N/A physical interaction ComPPI
PHC2 MAPKAPK3 25348397 N/A physical interaction ComPPI
EZH2 MAPKAPK3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SRC MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
FBXW7 MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RB1 MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPK14 MAPKAPK3 11157753 14525934 23455922 23602568 24234451 25241761 25348397 25852190 26496610 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
CDH1 MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
THAP12 MAPKAPK3 25348397 N/A physical interaction ComPPI
PTPN5 MAPKAPK3 25348397 N/A physical interaction ComPPI
PTPN7 MAPKAPK3 25348397 N/A physical interaction ComPPI
MAPK13 MAPKAPK3 14525934 24234451 25241761 25348397 9207191 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
PTPRR MAPKAPK3 25348397 N/A physical interaction ComPPI
PKM MAPKAPK3 25348397 N/A protein kinase assay ComPPI
RAB2A MAPKAPK3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEDD4L MAPKAPK3 25348397 N/A physical interaction ComPPI
SUMO3 MAPKAPK3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EGFR MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RNF2 MAPKAPK3 25348397 N/A physical interaction ComPPI
MEF2A MAPKAPK3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HSPB1 MAPKAPK3 14525934 21575178 24234451 25241761 25348397 8774846 phosphorylation reaction,physical association experimental interaction detection,physical interaction,protein kinase assay,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
STK11 MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
AURKA MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
COPS6 MAPKAPK3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEDD4 MAPKAPK3 25348397 N/A physical interaction ComPPI
BECN1 MAPKAPK3 25348397 N/A physical interaction ComPPI
MAPKAPK3 EEF2K 12171600 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK3 EEF2 12171600 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK3 TCF3 10781029 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAPKAPK3 SMS 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPKAPK3 APP 25348397 N/A physical interaction ComPPI
MAPKAPK3 MAPK11 21988832 23602568 24234451 25348397 association,physical association two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
MAPKAPK3 SRPK2 25348397 N/A physical interaction ComPPI
MAPKAPK3 ATF1 25348397 N/A physical interaction ComPPI
MAPKAPK3 RCSD1 25348397 N/A physical interaction ComPPI
MAPKAPK3 PTPDC1 25348397 N/A physical interaction ComPPI
MAPKAPK3 IGHM 21900206 24234451 25348397 physical association two hybrid ComPPI,IntAct
MAPKAPK3 BRAF 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPKAPK3 CDKN2A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPKAPK3 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPKAPK3 DLC1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPKAPK3 NRAS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPKAPK3 PDGFRL 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPK14 MAPKAPK3 10581204 11157753 17906627 23455922 23602568 25241761 25852190 26186194 26496610 27898060 8626550 9922370 stimulant N/A OmniPath
MAPKAPK3 HSPB2 18266962 27898060 stimulant N/A OmniPath
MAPKAPK3 BECN1 23878393 25693418 27898060 N/A N/A OmniPath
MAPKAPK3 HSPB1 10383393 1332886 16565220 16964243 17081983 17924679 18088087 18212344 18266962 18578522 18669648 18691976 18707149 18767875 19007248 19415658 19562805 19651622 19664994 19664995 19691289 20058876 20068231 20166139 20230923 21575178 25241761 27898060 8774846 stimulant N/A OmniPath
MAPKAPK3 TAB3 18021073 27898060 N/A N/A OmniPath
MAPKAPK3 RCSD1 15850461 19367720 19690332 27898060 N/A N/A OmniPath

Visualization










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