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GENE：UBA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBA2
FullNmae ubiquitin like modifier activating enzyme 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30661
EnsembleID ENSG00000126261
Uniprot Q9UBT2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBA2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBA2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
UBA2 GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005654,GO:0005737,GO:0016740,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0019948,GO:0019948,GO:0019948,GO:0031510,GO:0031510,GO:0031510,GO:0032183,GO:0033235,GO:0044388,GO:0044390,GO:0046982

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBA2 hsa:10054 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
UBA2 SAE1 10187858 21120624 23180781 other modification,sumoylation reaction,physical association gst pull down,enzymatic study InnateDB
UBA2 SUMO1 10187858 23180781 other modification enzymatic study InnateDB
UBA2 UBE2E3 10187858 23180781 other modification enzymatic study InnateDB
NFKBIA UBA2 10187858 23180781 other modification sumoylation reaction InnateDB
UBE2I UBA2 12764129 23180781 sumoylation,physical association sumoylation reaction InnateDB
PIAS2 UBA2 12764129 23180781 sumoylation,physical association sumoylation reaction InnateDB
UBA2 PELI1 21120624 23180781 sumoylation reaction enzymatic study InnateDB

Source Target Pmid Interactiontype Methods Database
AR UBA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 UBA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UBA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 UBA2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000007A060 UBA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 UBA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE UBA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 UBA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B UBA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 UBA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 UBA2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D UBA2 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBA2 NEDD8 25361965 interaction type N/A PTMCode2
NEDD8 UBA2 25361965 interaction type N/A PTMCode2
UBA2 SAE1 25361965 interaction type N/A PTMCode2
SAE1 UBA2 25361965 interaction type N/A PTMCode2
UBA2 RANBP2 25361965 interaction type N/A PTMCode2
RANBP2 UBA2 25361965 interaction type N/A PTMCode2
UBA2 SUMO2 25361965 interaction type N/A PTMCode2
SUMO2 UBA2 25361965 interaction type N/A PTMCode2
UBA2 RAD23B 25361965 interaction type N/A PTMCode2
RAD23B UBA2 25361965 interaction type N/A PTMCode2
UBA2 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 UBA2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I UBA2 12354763 12641448 12764129 14525934 15738391 16455490 17353931 18691969 19250909 21209884 21518767 21518904 24234451 25348397 26344197 26496610 27898060 9341106 9920803 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CBSL UBA2 25348397 N/A physical interaction ComPPI
BAG3 UBA2 25348397 N/A physical interaction ComPPI
LCA5 UBA2 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WAS UBA2 25348397 N/A physical interaction ComPPI
TRAF6 UBA2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLNS1A UBA2 25348397 N/A physical interaction ComPPI
PCBD1 UBA2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TACC3 UBA2 25348397 N/A physical interaction ComPPI
TLE3 UBA2 25348397 N/A physical interaction ComPPI
SUMO1 UBA2 20164921 24234451 25348397 25416956 physical association cross-linking study,physical interaction,two hybrid array,comigration in sds page,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMA3 UBA2 25348397 N/A physical interaction ComPPI
UBC UBA2 25348397 N/A physical interaction ComPPI
NTRK1 UBA2 25348397 N/A physical interaction ComPPI
P4HB UBA2 25348397 N/A physical interaction ComPPI
PSMA1 UBA2 25348397 N/A physical interaction ComPPI
PSMA5 UBA2 25348397 N/A physical interaction ComPPI
TRIP6 UBA2 25348397 N/A physical interaction ComPPI
PDLIM5 UBA2 25348397 N/A physical interaction ComPPI
PKM UBA2 25348397 N/A physical interaction ComPPI
UBE2B UBA2 25348397 N/A physical interaction ComPPI
RABGGTA UBA2 25348397 N/A physical interaction ComPPI
UBQLN2 UBA2 25348397 N/A physical interaction ComPPI
TOM1L2 UBA2 25348397 N/A physical interaction ComPPI
SUMO2 UBA2 14525934 16620772 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SAE1 UBA2 10187858 10217437 14525934 15660128 16189514 17353931 20164921 24234451 25348397 26496610 9920803 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
UBA2 SUMO3 12924945 14525934 16620772 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBA2 NEDD8 10217437 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBA2 BRIX1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
UBA2 RAD23B 14525934 17662948 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBA2 ETV4 25348397 N/A physical interaction ComPPI
UBA2 SERBP1 25348397 N/A physical interaction ComPPI
UBA2 PARK7 15983381 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBA2 THADA 25348397 N/A physical interaction ComPPI
UBA2 CHMP5 25348397 N/A physical interaction ComPPI
UBA2 AHCYL1 25348397 N/A physical interaction ComPPI
UBA2 SRSF2 25348397 N/A physical interaction ComPPI
UBA2 SEPHS2 25348397 N/A physical interaction ComPPI
UBA2 UNK 25348397 N/A physical interaction ComPPI
UBA2 ZFYVE19 25348397 N/A physical interaction ComPPI
UBA2 USP34 25348397 N/A physical interaction ComPPI
UBA2 YAP1 25348397 N/A physical interaction ComPPI
UBA2 NAP1L1 25348397 N/A physical interaction ComPPI
UBA2 RPS15A 25348397 N/A physical interaction ComPPI
UBA2 SULT1A1 25348397 N/A physical interaction ComPPI
UBA2 SHTN1 25348397 N/A physical interaction ComPPI
UBA2 STMN2 25348397 N/A physical interaction ComPPI
UBA2 SNCG 25348397 N/A physical interaction ComPPI
UBA2 TTC9C 25348397 N/A physical interaction ComPPI
UBA2 MYL1 25348397 N/A physical interaction ComPPI
UBA2 SRXN1 25348397 N/A physical interaction ComPPI
UBA2 CTSC 25348397 N/A physical interaction ComPPI
UBA2 PDE12 25348397 N/A physical interaction ComPPI
UBA2 SSB 25348397 N/A physical interaction ComPPI
UBA2 TCEAL4 25348397 N/A physical interaction ComPPI
UBA2 ARIH1 25348397 N/A physical interaction ComPPI
UBA2 CBS 25348397 N/A physical interaction ComPPI
UBA2 EHD4 25348397 N/A physical interaction ComPPI
UBA2 IREB2 25348397 N/A physical interaction ComPPI
UBA2 NPLOC4 25348397 N/A physical interaction ComPPI
UBA2 PLIN3 25348397 N/A physical interaction ComPPI
UBA2 SRP14 25348397 N/A physical interaction ComPPI
UBA2 ZPR1 25348397 N/A physical interaction ComPPI
UBA2 EGFR 25348397 N/A physical interaction ComPPI
UBA2 AP5Z1 25348397 N/A physical interaction ComPPI
UBA2 FOXK1 25348397 N/A physical interaction ComPPI
UBA2 PSMA4 25348397 N/A physical interaction ComPPI
UBA2 CLIC4 25348397 N/A physical interaction ComPPI
UBA2 HSPB1 25348397 N/A physical interaction ComPPI
UBA2 PCF11 25348397 N/A physical interaction ComPPI
UBA2 PSMA2 25348397 N/A physical interaction ComPPI
UBA2 WDR11 25348397 N/A physical interaction ComPPI
UBA2 CEP162 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBA2 OFD1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBA2 RANBP2 25348397 N/A physical interaction ComPPI
UBA2 CHEK1 25348397 N/A physical interaction ComPPI
UBA2 DERL1 25348397 N/A physical interaction ComPPI
UBA2 CPNE5 25348397 N/A physical interaction ComPPI
UBA2 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBA2 EDEM3 25348397 N/A physical interaction ComPPI
UBA2 TRIM25 25348397 N/A physical interaction ComPPI
UBA2 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBA2 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBA2 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBA2 RNF169 21252943 24234451 25348397 association pull down ComPPI,IntAct
UBA2 SUMO1P1 24234451 25348397 25416956 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBA2 SETX 24234451 24244371 25348397 physical association two hybrid ComPPI,IntAct
UBA2 ESRRA 18063693 24234451 25348397 sumoylation reaction sumoylase assay ComPPI,IntAct
UBA2 ESRRG 18063693 24234451 25348397 sumoylation reaction sumoylase assay ComPPI,IntAct
PSMB4 UBA2 25348397 N/A physical interaction ComPPI
PSMB3 UBA2 25348397 N/A physical interaction ComPPI
CALU UBA2 25348397 N/A physical interaction ComPPI
ATP6V1B2 UBA2 25348397 N/A physical interaction ComPPI
MRE11 UBA2 23443654 25231868 27898060 N/A N/A OmniPath

Visualization










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