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GENE：UBE2D4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE2D4
FullNmae ubiquitin conjugating enzyme E2 D4 (putative)
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21647
EnsembleID ENSG00000078967
Uniprot Q9Y2X8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE2D4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBE2D4 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
UBE2D4 cuproptosis 38348451 Ubiquitin-conjugating enzymes. Involved in protein degradation pathways that may be implicated in cuproptosis. CRGs in the cuproptosis pathway
UBE2D4 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
UBE2D4 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
UBE2D4 GO:0000151,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0006511,GO:0016567,GO:0031625,GO:0035519,GO:0044314,GO:0061631,GO:0061631,GO:0070534,GO:0070534,GO:0070936,GO:0070936,GO:0070979,GO:0070979,GO:0085020

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE2D4 hsa:51619 path:hsa03083 Polycomb repressive complex - Homo sapiens (human)
UBE2D4 hsa:51619 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
UBE2D4 hsa:51619 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
UBE2D4 hsa:51619 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
UBE2D4 DTX2 16189514 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 UBE2D4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA UBE2D4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UBE2D4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000202460 UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000024B619 UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002E177F UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 UBE2D4 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004B83FE UBE2D4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E UBE2D4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRIM38 UBE2D4 25348397 N/A physical interaction ComPPI
TRAF6 UBE2D4 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XIAP UBE2D4 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RING1 UBE2D4 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBTD1 UBE2D4 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 RNF5 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 MAGEA11 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2D4 TRIM39 14525934 16189514 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
UBE2D4 RNF126 16189514 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 DTX2 14525934 16189514 19549727 24234451 25348397 25416956 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
UBE2D4 RNF11 14525934 15231748 19549727 19690564 21516116 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2D4 UFM1 25348397 N/A physical interaction ComPPI
UBE2D4 AMFR 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MUL1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 CADPS2 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 CNOT4 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 DTX1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 UBE4A 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF103 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF181 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MIB1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MID2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2D4 PJA2 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RFWD3 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RMND5B 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF111 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF13 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF130 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF150 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF165 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF167 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF25 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF43 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 SIAH1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF4 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TOPORS 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 UHRF2 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 ZNRF1 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 ZNRF2 25348397 N/A physical interaction ComPPI
UBE2D4 ZNRF4 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF125 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF138 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 UBOX5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 DTX3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 RNF14 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 RNF114 19549727 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2D4 TRIM8 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 DTX3L 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 DZIP3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MID1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 RNF10 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF166 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 RNF185 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 RNF2 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 TRIM43 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 BIRC8 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 BFAR 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RCHY1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRAF7 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MARCHF3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RLIM 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 LRSAM1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 CHFR 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MGRN1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MKRN3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM27 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF38 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RNF7 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM17 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM2 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM25 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM31 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM35 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RBCK1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 TRIM3 25348397 N/A physical interaction ComPPI
UBE2D4 TRIM10 25348397 N/A physical interaction ComPPI
UBE2D4 TRIM45 25348397 N/A physical interaction ComPPI
UBE2D4 TRIM50 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 MYLIP 25348397 N/A physical interaction ComPPI
UBE2D4 MYBL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 UBE2D3 25348397 N/A physical interaction ComPPI
UBE2D4 RNF26 19549727 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2D4 DAZAP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 MKRN2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 PHF7 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 OTUB1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 INCA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D4 UBA1 25348397 N/A physical interaction ComPPI
UBE2D4 MCM2 25348397 N/A physical interaction ComPPI
UBE2D4 F3 25348397 N/A physical interaction ComPPI
UBE2D4 TRIM23 25348397 N/A physical interaction ComPPI
UBE2D4 STUB1 25348397 N/A physical interaction ComPPI
UBE2D4 PRKN 25348397 N/A physical interaction ComPPI
UBE2D4 UFL1 19690564 24234451 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
UBE2D4 SNURF 19690564 24234451 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
UBE2D4 ALDH1A2 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2D4 CARM1 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2D4 ZNFX1 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2D4 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 UBTD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 TRIM54 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 MKRN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 IKBKG 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 TRIM62 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D4 POLR2E 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF115 UBE2D4 19690564 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ARIH2 UBE2D4 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct

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