GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
UQCC2
FullNmae
ubiquinol-cytochrome c reductase complex assembly factor 2
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:21237
EnsembleID
ENSG00000137288
Uniprot
Q9BRT2
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
UQCC2
cuproptosis
36010978
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1.
Cuproptosis-related genes
Go Annotation:
GeneSymbol
Go id
UQCC2
GO:0002082,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005759,GO:0016604,GO:0034551,GO:0034551,GO:0042645,GO:0050796,GO:0070131,GO:2001014
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
ETS1
UQCC2
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
YBX1
UQCC2
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
TFAP2C
UQCC2
20629094
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
SMARCA4
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F4
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
MITF
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
RUNX1
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
ZNF263
UQCC2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00003CF1AD
UQCC2
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
CHCHD2
UQCC2
25348397
N/A
physical interaction
ComPPI
TXN2
UQCC2
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
CDR2
UQCC2
24234451
25348397
27173435
association,physical association
physical interaction,tandem affinity purification,inference by socio-affinity scoring
ComPPI,IntAct
GRB2
UQCC2
24234451
25348397
25814554
physical association
two hybrid,physical interaction,two hybrid array,validated two hybrid
ComPPI,IntAct
VHL
UQCC2
17353931
24234451
25348397
physical association
anti bait coimmunoprecipitation
ComPPI,IntAct
HSPB1
UQCC2
24234451
25277244
25348397
physical association
reverse ras recruitment system,physical interaction
ComPPI,IntAct
AURKA
UQCC2
25348397
N/A
physical interaction
ComPPI
PDK1
UQCC2
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
TRIM25
UQCC2
25348397
N/A
physical interaction
ComPPI
IKBKE
UQCC2
17353931
24234451
25348397
physical association
anti bait coimmunoprecipitation
ComPPI,IntAct
CEACAM5
UQCC2
21988832
24234451
25348397
physical association
two hybrid,physical interaction,two hybrid array
ComPPI,IntAct
TUBGCP2
UQCC2
25348397
N/A
physical interaction
ComPPI
TUBGCP4
UQCC2
25348397
N/A
physical interaction
ComPPI
CEP76
UQCC2
25348397
N/A
physical interaction
ComPPI
NDUFA4
UQCC2
25348397
N/A
physical interaction
ComPPI
UQCC2
COX20
25348397
N/A
physical interaction
ComPPI
UQCC2
TM2D2
25348397
N/A
physical interaction
ComPPI
Visualization