Gene Information gene info

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GENE：UQCRC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UQCRC1
FullNmae ubiquinol-cytochrome c reductase core protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12585
EnsembleID ENSG00000010256
Uniprot P31930

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UQCRC1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
UQCRC1 GO:0005515,GO:0005739,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0008121,GO:0009060,GO:0014823,GO:0031625,GO:0043279,GO:0044877,GO:0045333,GO:0046872,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UQCRC1 hsa:7384 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa01100 Metabolic pathways - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa04714 Thermogenesis - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05010 Alzheimer disease - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05012 Parkinson disease - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05016 Huntington disease - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05020 Prion disease - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
UQCRC1 hsa:7384 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-CYB UQCRC1 15807660 26192618 interaction type N/A ACSN
UQCRB UQCRC1 15807660 26192618 interaction type N/A ACSN
UQCRC1 CYC1 15807660 26192618 interaction type N/A ACSN
UQCRC2 UQCRC1 15807660 26192618 interaction type N/A ACSN
UQCRFS1 UQCRC1 15807660 26192618 interaction type N/A ACSN
UQCRH UQCRC1 15807660 26192618 interaction type N/A ACSN
UQCRQ UQCRC1 15807660 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 UQCRC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF UQCRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 UQCRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UQCRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UQCRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UQCRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000002103A UQCRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D UQCRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB UQCRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 UQCRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F UQCRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
UQCRC1 UQCRFS1 25361965 interaction type N/A PTMCode2
UQCRFS1 UQCRC1 25361965 interaction type N/A PTMCode2
UQCRC1 CYCS 25361965 interaction type N/A PTMCode2
CYCS UQCRC1 25361965 interaction type N/A PTMCode2
UQCRC1 UQCRH 25361965 interaction type N/A PTMCode2
UQCRH UQCRC1 25361965 interaction type N/A PTMCode2
UQCRC1 CYC1 25361965 interaction type N/A PTMCode2
CYC1 UQCRC1 25361965 interaction type N/A PTMCode2
UQCRC1 UQCR10 25361965 interaction type N/A PTMCode2
UQCR10 UQCRC1 25361965 interaction type N/A PTMCode2
UQCRC1 TRIM63 25361965 interaction type N/A PTMCode2
TRIM63 UQCRC1 25361965 interaction type N/A PTMCode2
UQCRC1 UQCRQ 25361965 interaction type N/A PTMCode2
UQCRQ UQCRC1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRAS UQCRC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATP5F1B UQCRC1 25348397 N/A physical interaction ComPPI
SNRPF UQCRC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT1 UQCRC1 24234451 25348397 26966684 association pull down ComPPI,IntAct
UBL4A UQCRC1 25348397 N/A physical interaction ComPPI
MCM2 UQCRC1 25348397 N/A physical interaction ComPPI
SLC25A6 UQCRC1 25348397 N/A physical interaction ComPPI
CYCS UQCRC1 14525934 25348397 6251869 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UQCRH UQCRC1 25348397 N/A physical interaction ComPPI
VAPA UQCRC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC UQCRC1 25348397 N/A physical interaction ComPPI
DLD UQCRC1 25348397 N/A physical interaction ComPPI
NTRK1 UQCRC1 25348397 N/A physical interaction ComPPI
PLEC UQCRC1 25348397 N/A physical interaction ComPPI
HNRNPL UQCRC1 25348397 N/A physical interaction ComPPI
DCTN1 UQCRC1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CFTR UQCRC1 25348397 N/A physical interaction ComPPI
NPHP1 UQCRC1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VDAC1 UQCRC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ABCB7 UQCRC1 25348397 N/A physical interaction ComPPI
PDHA1 UQCRC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HTT UQCRC1 17500595 24234451 25348397 association pull down ComPPI,IntAct
PHB2 UQCRC1 25348397 N/A physical interaction ComPPI
TRIM63 UQCRC1 18157088 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RTN4 UQCRC1 12067236 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
UQCRC2 UQCRC1 11073949 14525934 17353931 19688755 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,blue native page,in vitro ComPPI,HPRD,IntAct
UQCRC1 RUVBL2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 SRPRB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 DNAJA1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 SIRT7 25348397 N/A physical interaction ComPPI
UQCRC1 ATP5F1C 25348397 N/A physical interaction ComPPI
UQCRC1 NDUFV2 25348397 N/A physical interaction ComPPI
UQCRC1 SLC25A4 25348397 N/A physical interaction ComPPI
UQCRC1 HSPA1L 25348397 N/A physical interaction ComPPI
UQCRC1 ILF3 25348397 N/A physical interaction ComPPI
UQCRC1 FKBP8 25348397 N/A physical interaction ComPPI
UQCRC1 SURF1 25348397 N/A physical interaction ComPPI
UQCRC1 HNRNPD 25348397 N/A physical interaction ComPPI
UQCRC1 MOV10 25348397 N/A physical interaction ComPPI
UQCRC1 NXF1 25348397 N/A physical interaction ComPPI
UQCRC1 UQCRB 19688755 24234451 25348397 physical association physical interaction,blue native page ComPPI,IntAct
UQCRC1 LMAN1 25348397 N/A physical interaction ComPPI
UQCRC1 PMPCA 25348397 N/A physical interaction ComPPI
UQCRC1 POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
UQCRC1 NDUFA12 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC1 FOXH1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
UQCRC1 FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
UQCRC1 NLGN3 25348397 N/A physical interaction ComPPI
UQCRC1 UQCRQ 19688755 24234451 25348397 physical association physical interaction,blue native page ComPPI,IntAct
UQCRC1 STOM 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
UQCRC1 SOAT1 24234451 25348397 29128334 association,physical association cross-linking study,physical interaction,inference by socio-affinity scoring ComPPI,IntAct
UQCRC1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UQCRC1 TARDBP 25348397 N/A physical interaction ComPPI
UQCRC1 UQCR10 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
UQCRC1 UQCRFS1 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
UQCRC1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC1 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UQCRC1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 UQCRC1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 UQCRC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BDKRB1 UQCRC1 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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