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GENE：VARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VARS2
FullNmae valyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21642
EnsembleID ENSG00000137411
Uniprot Q5ST30

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
VARS2 GO:0002161,GO:0004832,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006438,GO:0106074

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VARS2 hsa:57176 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR VARS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 VARS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 VARS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 VARS2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 VARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
NCK2 VARS2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SORBS3 VARS2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3CA VARS2 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ABI3 VARS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ABI2 VARS2 25348397 N/A physical interaction ComPPI
PDK1 VARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS7 VARS2 25348397 N/A physical interaction ComPPI
HSPD1 VARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRMT61B VARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VARS2 CMTM5 25348397 N/A physical interaction ComPPI

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