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GENE：WARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WARS2
FullNmae tryptophanyl tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12730
EnsembleID ENSG00000116874
Uniprot Q9UGM6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WARS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WARS2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
WARS2 GO:0001570,GO:0004830,GO:0004830,GO:0005524,GO:0005654,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005759,GO:0005886,GO:0006418,GO:0045766,GO:0070183

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
WARS2 hsa:10352 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR WARS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 WARS2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 WARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 WARS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 WARS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 WARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 WARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF WARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 WARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 WARS2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 WARS2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000427B68 WARS2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 WARS2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA WARS2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 WARS2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 WARS2 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDK1 WARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP WARS2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
APP WARS2 25348397 N/A physical interaction ComPPI
TRMT61B WARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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