GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
WDR12
FullNmae
WD repeat domain 12
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:14098
EnsembleID
ENSG00000138442
Uniprot
Q9GZL7
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
WDR12
cuproptosis
36010978
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1.
Cuproptosis-related genes
Go Annotation:
GeneSymbol
Go id
WDR12
GO:0000463,GO:0000463,GO:0000466,GO:0000466,GO:0005515,GO:0005654,GO:0005654,GO:0005730,GO:0007219,GO:0030687,GO:0030687,GO:0042273,GO:0043021,GO:0051726,GO:0070545,GO:0070545
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
RNF2
WDR12
23180781
24457600
physical association
anti tag coimmunoprecipitation
InnateDB
BMI1
WDR12
23180781
24457600
physical association
anti tag coimmunoprecipitation
InnateDB
Source
Target
Pmid
Interactiontype
Methods
Database
AR
WDR12
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
E2F4
WDR12
17531812
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
ETS1
WDR12
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
HIF1A
WDR12
19828020
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
FOXP3
WDR12
20554955
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
SMARCA4
WDR12
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
WDR12
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
WDR12
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
MITF
WDR12
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
SPI1
WDR12
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS0000065D58
WDR12
18668040
25416803
mrna cleavage,inhibition
experimental interaction detection
TarBase
URS00000AA464
WDR12
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS000075D814
WDR12
21572407
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS000075CC78
WDR12
21572407
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS0000411672
WDR12
21572407
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS00001012BC
WDR12
21572407
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS000075BDAA
WDR12
21572407
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS000021202F
WDR12
21572407
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS00001F373E
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000366551
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000011166D
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000209905
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000016FD1A
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000032AE90
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000100748
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000075C4B1
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000753AD
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000451A1
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00003ACE11
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001F0C23
WDR12
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000427B68
WDR12
21572407
25416803
mrna cleavage,inhibition
clip
TarBase
URS00004719AB
WDR12
21572407
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000045DBD
WDR12
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS0000508C13
WDR12
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
URS00005D986D
WDR12
25416803
27292025
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
WDR12
PES1
25361965
interaction type
N/A
PTMCode2
PES1
WDR12
25361965
interaction type
N/A
PTMCode2
Source
Target
Pmid
Interactiontype
Methods
Database
BYSL
WDR12
25348397
N/A
physical interaction
ComPPI
DDX6
WDR12
25348397
N/A
physical interaction
ComPPI
TXN2
WDR12
25348397
N/A
physical interaction
ComPPI
BMI1
WDR12
25348397
N/A
physical interaction
ComPPI
NIFK
WDR12
25348397
N/A
physical interaction
ComPPI
TUFM
WDR12
25348397
N/A
physical interaction
ComPPI
VPS37B
WDR12
25348397
N/A
physical interaction
ComPPI
ACBD3
WDR12
25348397
N/A
physical interaction
ComPPI
NOTCH1
WDR12
11827460
14525934
25348397
N/A
experimental interaction detection,in vivo
ComPPI,HPRD
BTRC
WDR12
25348397
N/A
physical interaction
ComPPI
PPP2CB
WDR12
25348397
N/A
physical interaction
ComPPI
GRK5
WDR12
25348397
N/A
physical interaction
ComPPI
XPO1
WDR12
25348397
N/A
physical interaction
ComPPI
TBCD
WDR12
25348397
N/A
physical interaction
ComPPI
RPS6
WDR12
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
RPL4
WDR12
25348397
N/A
physical interaction
ComPPI
RNF2
WDR12
25348397
N/A
physical interaction
ComPPI
CASQ2
WDR12
25348397
N/A
physical interaction
ComPPI
WDR12
H1-2
25348397
N/A
physical interaction
ComPPI
WDR12
SIRT7
25348397
N/A
physical interaction
ComPPI
WDR12
BOP1
16043514
24234451
25348397
association
anti bait coimmunoprecipitation,physical interaction,comigration in non denaturing gel electrophoresis
ComPPI,IntAct
WDR12
PES1
16043514
24234451
25348397
30021884
association,physical association
anti bait coimmunoprecipitation,cross-linking study,physical interaction
ComPPI,IntAct
WDR12
TSG101
25348397
N/A
physical interaction
ComPPI
WDR12
TOMM34
25348397
N/A
physical interaction
ComPPI
WDR12
USP14
25348397
N/A
physical interaction
ComPPI
WDR12
INPP1
25348397
N/A
physical interaction
ComPPI
WDR12
VAT1
25348397
N/A
physical interaction
ComPPI
WDR12
TBC1D13
25348397
N/A
physical interaction
ComPPI
WDR12
SUGT1
25348397
N/A
physical interaction
ComPPI
WDR12
SEPHS1
25348397
N/A
physical interaction
ComPPI
WDR12
UBE2Z
25348397
N/A
physical interaction
ComPPI
WDR12
PPP3CB
25348397
N/A
physical interaction
ComPPI
WDR12
RPUSD2
25348397
N/A
physical interaction
ComPPI
WDR12
SNF8
25348397
N/A
physical interaction
ComPPI
WDR12
SRSF5
25348397
N/A
physical interaction
ComPPI
WDR12
TOM1
25348397
N/A
physical interaction
ComPPI
WDR12
TSN
25348397
N/A
physical interaction
ComPPI
WDR12
VPS29
25348397
N/A
physical interaction
ComPPI
WDR12
VPS36
25348397
N/A
physical interaction
ComPPI
WDR12
DNAAF10
25348397
N/A
physical interaction
ComPPI
WDR12
BRIX1
25348397
N/A
physical interaction
ComPPI
WDR12
CHMP7
25348397
N/A
physical interaction
ComPPI
WDR12
DDX19A
25348397
N/A
physical interaction
ComPPI
WDR12
DDX54
25348397
N/A
physical interaction
ComPPI
WDR12
FTSJ3
25348397
N/A
physical interaction
ComPPI
WDR12
GTPBP4
25348397
N/A
physical interaction
ComPPI
WDR12
HNRNPDL
25348397
N/A
physical interaction
ComPPI
WDR12
NOC3L
25348397
N/A
physical interaction
ComPPI
WDR12
PUS1
25348397
N/A
physical interaction
ComPPI
WDR12
CSNK2B
25348397
N/A
physical interaction
ComPPI
WDR12
DDX24
25348397
N/A
physical interaction
ComPPI
WDR12
MRTO4
25348397
N/A
physical interaction
ComPPI
WDR12
PSPC1
25348397
N/A
physical interaction
ComPPI
WDR12
RPL36
25348397
N/A
physical interaction
ComPPI
WDR12
RPL7
25348397
N/A
physical interaction
ComPPI
WDR12
RTCB
25348397
N/A
physical interaction
ComPPI
WDR12
IFI16
25348397
N/A
physical interaction
ComPPI
WDR12
FBXW11
25348397
N/A
physical interaction
ComPPI
WDR12
MDN1
25348397
N/A
physical interaction
ComPPI
WDR12
DDX27
25348397
N/A
physical interaction
ComPPI
WDR12
KMT2E
25348397
N/A
physical interaction
ComPPI
WDR12
WDR55
25348397
N/A
physical interaction
ComPPI
WDR12
IGHMBP2
25348397
N/A
physical interaction
ComPPI
WDR12
DGCR8
25348397
N/A
physical interaction
ComPPI
WDR12
FOXA1
25348397
N/A
physical interaction
ComPPI
WDR12
MNDA
24234451
25348397
25665578
association
anti tag coimmunoprecipitation
ComPPI,IntAct
WDR12
RRP1B
20926688
24234451
25348397
association
anti tag coimmunoprecipitation
ComPPI,IntAct
DDX19B
WDR12
25348397
N/A
physical interaction
ComPPI
WDR5
WDR12
25348397
N/A
physical interaction
ComPPI
VPS25
WDR12
25348397
N/A
physical interaction
ComPPI
EBNA1BP2
WDR12
25348397
N/A
physical interaction
ComPPI
WDR12
TMCO5A
24234451
30021884
physical association
cross-linking study
IntAct
Visualization