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GENE：XRN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XRN1
FullNmae 5'-3' exoribonuclease 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30654
EnsembleID ENSG00000114127
Uniprot Q8IZH2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XRN1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
XRN1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
XRN1 GO:0000932,GO:0000956,GO:0000956,GO:0002151,GO:0003723,GO:0003723,GO:0004534,GO:0004534,GO:0004534,GO:0005515,GO:0005634,GO:0005829,GO:0005829,GO:0005886,GO:0016020,GO:0016075,GO:0016075,GO:0017148,GO:0030425,GO:0032211,GO:0033574,GO:0043025,GO:0051880,GO:0070034,GO:0071028,GO:0071044,GO:0071409,GO:1905795

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XRN1 hsa:54464 path:hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human)
XRN1 hsa:54464 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR XRN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 XRN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF XRN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 XRN1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 XRN1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016D2D4 XRN1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000324096 XRN1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00004719AB XRN1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 XRN1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F XRN1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C XRN1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 XRN1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 XRN1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 XRN1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
XRN1 UPF3B 25361965 interaction type N/A PTMCode2
UPF3B XRN1 25361965 interaction type N/A PTMCode2
XRN1 LSM6 25361965 interaction type N/A PTMCode2
LSM6 XRN1 25361965 interaction type N/A PTMCode2
XRN1 LSM2 25361965 interaction type N/A PTMCode2
LSM2 XRN1 25361965 interaction type N/A PTMCode2
LSM8 XRN1 25361965 interaction type N/A PTMCode2
XRN1 LSM8 25361965 interaction type N/A PTMCode2
ZFP36 XRN1 25361965 interaction type N/A PTMCode2
XRN1 ZFP36 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFB9 XRN1 25348397 N/A physical interaction ComPPI
RPS7 XRN1 25348397 N/A physical interaction ComPPI
LDHA XRN1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
BMI1 XRN1 25348397 N/A physical interaction ComPPI
EXOSC1 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC8 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
AP1G2 XRN1 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DCP1A XRN1 16364915 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
FGF3 XRN1 25348397 N/A physical interaction ComPPI
JUN XRN1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CTSB XRN1 25348397 N/A physical interaction ComPPI
RBM4 XRN1 25348397 N/A physical interaction ComPPI
TUBG1 XRN1 25348397 N/A physical interaction ComPPI
NTRK1 XRN1 25348397 N/A physical interaction ComPPI
CDH1 XRN1 25348397 N/A physical interaction ComPPI
BAG6 XRN1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RPA1 XRN1 25348397 N/A physical interaction ComPPI
POLD2 XRN1 25348397 N/A physical interaction ComPPI
MYC XRN1 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
LEPR XRN1 25348397 N/A physical interaction ComPPI
NAGK XRN1 25348397 N/A physical interaction ComPPI
PABPC4 XRN1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DCP1B XRN1 25348397 N/A two hybrid,physical interaction ComPPI
STAM2 XRN1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ZFP36 XRN1 25348397 N/A two hybrid,physical interaction ComPPI
CEP135 XRN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP2CA XRN1 25348397 N/A physical interaction ComPPI
XPO1 XRN1 25348397 N/A physical interaction ComPPI
RPA2 XRN1 25348397 N/A physical interaction ComPPI
RPA3 XRN1 25348397 N/A physical interaction ComPPI
UPF2 XRN1 14525934 14527413 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EXOSC10 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CBX5 XRN1 25348397 N/A physical interaction ComPPI
SYNCRIP XRN1 25348397 N/A physical interaction ComPPI
CCT5 XRN1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MTREX XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SSX2IP XRN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EXOSC6 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CENPJ XRN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RBMX XRN1 25348397 N/A physical interaction ComPPI
UPF3B XRN1 14525934 14527413 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UPF1 XRN1 14525934 14527413 18423202 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
XRN1 SMARCD2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN1 DPP7 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN1 SPATA20 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN1 CENPBD1 14525934 15231747 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
XRN1 NDUFA13 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN1 HEATR1 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRN1 WAPL 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRN1 DXO 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
XRN1 ALDOA 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN1 HNRNPA1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN1 CHD4 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRN1 UPF3A 25348397 N/A physical interaction ComPPI
XRN1 MLH1 25348397 N/A physical interaction ComPPI
XRN1 SIRT7 25348397 N/A physical interaction ComPPI
XRN1 SKIV2L 14525934 15231747 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
XRN1 VWA5B2 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRN1 NDUFB10 25348397 N/A physical interaction ComPPI
XRN1 PSMB5 25348397 N/A physical interaction ComPPI
XRN1 KATNB1 25348397 N/A physical interaction ComPPI
XRN1 MAN2C1 25348397 N/A physical interaction ComPPI
XRN1 FADS1 25348397 N/A physical interaction ComPPI
XRN1 TMEM50A 25348397 N/A physical interaction ComPPI
XRN1 MTCH2 25348397 N/A physical interaction ComPPI
XRN1 SRRM2 25348397 N/A physical interaction ComPPI
XRN1 C1GALT1 25348397 N/A physical interaction ComPPI
XRN1 MFSD5 25348397 N/A physical interaction ComPPI
XRN1 ADGRE5 25348397 N/A physical interaction ComPPI
XRN1 B3GALT6 25348397 N/A physical interaction ComPPI
XRN1 GLMP 25348397 N/A physical interaction ComPPI
XRN1 PLEKHG2 25348397 N/A physical interaction ComPPI
XRN1 RNF187 25348397 N/A physical interaction ComPPI
XRN1 CTSH 25348397 N/A physical interaction ComPPI
XRN1 ATP5MC2 25348397 N/A physical interaction ComPPI
XRN1 DNASE2 25348397 N/A physical interaction ComPPI
XRN1 SDHB 25348397 N/A physical interaction ComPPI
XRN1 LGALS3BP 25348397 N/A physical interaction ComPPI
XRN1 TARDBP 25348397 N/A physical interaction ComPPI
XRN1 HECW2 25348397 N/A physical interaction ComPPI
XRN1 SCRN2 25348397 N/A physical interaction ComPPI
XRN1 RPS4X 25348397 N/A physical interaction ComPPI
XRN1 ALYREF 25348397 N/A physical interaction ComPPI
XRN1 DDX24 25348397 N/A physical interaction ComPPI
XRN1 RPL5 25348397 N/A physical interaction ComPPI
XRN1 IFI16 25348397 N/A physical interaction ComPPI
XRN1 MED4 25348397 N/A physical interaction ComPPI
XRN1 PCM1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CC2D2A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP97 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 KIAA0753 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP104 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP120 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP152 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP44 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 CEP89 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 POC1A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 STIL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XRN1 PSMC1 25348397 N/A physical interaction ComPPI
XRN1 QSOX2 25348397 N/A physical interaction ComPPI
XRN1 ZNF131 25348397 N/A physical interaction ComPPI
XRN1 FGF8 25348397 N/A physical interaction ComPPI
XRN1 ZC3HAV1 21876179 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRN1 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
LSM4 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PRADC1 XRN1 25348397 N/A physical interaction ComPPI
ADPRH XRN1 25348397 N/A physical interaction ComPPI

Visualization










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