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GENE：YARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol YARS2
FullNmae tyrosyl-tRNA synthetase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24249
EnsembleID ENSG00000139131
Uniprot Q9Y2Z4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
YARS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
YARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
YARS2 GO:0000049,GO:0000049,GO:0003723,GO:0004831,GO:0004831,GO:0004831,GO:0005515,GO:0005524,GO:0005739,GO:0005739,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0016604,GO:0042803,GO:0043039,GO:0043039,GO:0070184,GO:0070184,GO:0072545

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
YARS2 hsa:51067 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 YARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 YARS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 YARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF YARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 YARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 YARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C770D YARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000475586 YARS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A513 YARS2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HNRNPK YARS2 25348397 N/A physical interaction ComPPI
RBM3 YARS2 25348397 N/A physical interaction ComPPI
BMI1 YARS2 25348397 N/A physical interaction ComPPI
YARS2 CDC20 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
YARS2 USP49 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YARS2 CUL3 25348397 N/A physical interaction ComPPI
YARS2 CAND1 25348397 N/A physical interaction ComPPI
YARS2 FAM9B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
YARS2 HNRNPDL 25348397 N/A physical interaction ComPPI
YARS2 ZC3H3 25348397 N/A physical interaction ComPPI
YARS2 MRPL4 25348397 N/A physical interaction ComPPI
YARS2 HNRNPA1 25348397 N/A physical interaction ComPPI
YARS2 RBMX 25348397 N/A physical interaction ComPPI
YARS2 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
YARS2 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
YARS2 ATOH1 25348397 N/A physical interaction ComPPI
YARS2 CIRBP 25348397 N/A physical interaction ComPPI
YARS2 FASTKD2 25348397 N/A physical interaction ComPPI
YARS2 ATP5F1D 25348397 N/A physical interaction ComPPI
YARS2 MRPL12 25348397 N/A physical interaction ComPPI
YARS2 SLC25A10 25348397 N/A physical interaction ComPPI
YARS2 RBM42 25348397 N/A physical interaction ComPPI
YARS2 HSPD1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
YARS2 MRM1 25348397 N/A physical interaction ComPPI
YARS2 NXF1 25348397 N/A physical interaction ComPPI
YARS2 UBC 25348397 N/A physical interaction ComPPI
YARS2 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
YARS2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRMT61B YARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
YARS2 MLLT1 24234451 30021884 physical association cross-linking study IntAct

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