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GENE：ZBP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ZBP1
FullNmae Z-DNA binding protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16176
EnsembleID ENSG00000124256
Uniprot Q9H171

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ZBP1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ZBP1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ZBP1 cuproptosis 38218941 Bioinformatics analysis further indicated an association between ZBP1 and cuproptosis as well as necroptosis. ZBP1 activation led to the recruitment of RIPK3 and caspase-8 to activate the NLRP3 inflammasome, which in turn triggers necroptosis and pyroptosis DRIVER

Go Annotation:

GeneSymbol Go id
ZBP1 GO:0002218,GO:0003677,GO:0003677,GO:0003692,GO:0003723,GO:0003725,GO:0003726,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006915,GO:0043065,GO:0050727,GO:0050729,GO:0050832,GO:0051607,GO:0051607,GO:0060340,GO:0060545,GO:0060545,GO:0070269,GO:0140374,GO:2000659

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ZBP1 hsa:81030 path:hsa04217 Necroptosis - Homo sapiens (human)
ZBP1 hsa:81030 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RIPK1 ZBP1 18941233 19590578 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 ZBP1 19590578 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 ZNF516 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 CTBP1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 TRAF3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 VPS35 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 PLXDC2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 PALD1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 CTBP2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 KDM1A 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 ORC3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ZBP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ZBP1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ZBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
IRF3 ZBP1 25361965 interaction type N/A PTMCode2
ZBP1 IRF3 25361965 interaction type N/A PTMCode2
RIPK3 ZBP1 25361965 interaction type N/A PTMCode2
ZBP1 RIPK3 25361965 interaction type N/A PTMCode2
TBK1 ZBP1 25361965 interaction type N/A PTMCode2
ZBP1 TBK1 25361965 interaction type N/A PTMCode2
KRR1 ZBP1 25361965 interaction type N/A PTMCode2
ZBP1 KRR1 25361965 interaction type N/A PTMCode2
IKBKE ZBP1 25361965 interaction type N/A PTMCode2
ZBP1 IKBKE 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CTBP1 ZBP1 25348397 N/A physical interaction ComPPI
CTBP2 ZBP1 25348397 N/A physical interaction ComPPI
SIAH1 ZBP1 25348397 N/A physical interaction ComPPI
TRAF3 ZBP1 25348397 N/A physical interaction ComPPI
TRIP6 ZBP1 25348397 N/A physical interaction ComPPI
RIPK1 ZBP1 22817896 24234451 25348397 N/A electron microscopy ComPPI,IntAct
RIPK3 ZBP1 19590578 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FMR1 ZBP1 25348397 N/A physical interaction ComPPI
ORC3 ZBP1 25348397 N/A physical interaction ComPPI
KDM1A ZBP1 25348397 N/A physical interaction ComPPI
VPS35 ZBP1 25348397 N/A physical interaction ComPPI
AGO2 ZBP1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AGO1 ZBP1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KLHL12 ZBP1 25348397 N/A physical interaction ComPPI
KRR1 ZBP1 19590578 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ZNF516 ZBP1 25348397 N/A physical interaction ComPPI
ZBP1 PALD1 25348397 N/A physical interaction ComPPI
ZBP1 PLXDC2 25348397 N/A physical interaction ComPPI
ZBP1 IRF3 17618271 27898060 N/A N/A OmniPath
ZBP1 CTBP1 21903422 27898060 N/A N/A OmniPath
ZBP1 KDM1A 21903422 27898060 N/A N/A OmniPath
ZBP1 RIPK1 18941233 19590578 22817896 27898060 N/A N/A OmniPath
ZBP1 TBK1 17618271 27898060 stimulant N/A OmniPath
ZBP1 TRAF3 21903422 27898060 N/A N/A OmniPath
ZBP1 PLXDC2 21903422 27898060 N/A N/A OmniPath
IL15 ZBP1 19590578 27898060 N/A N/A OmniPath
ZBP1 IL15 19590578 27898060 N/A N/A OmniPath
ZBP1 ORC3 21903422 27898060 N/A N/A OmniPath
ZBP1 VPS35 21903422 27898060 N/A N/A OmniPath
ZBP1 CTBP2 21903422 27898060 N/A N/A OmniPath
ZBP1 PALD1 21903422 27898060 N/A N/A OmniPath
ZBP1 ZNF516 21903422 27898060 N/A N/A OmniPath

Visualization










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