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GENE：NFKBIE

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NFKBIE
FullNmae NFKB inhibitor epsilon
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7799
EnsembleID ENSG00000146232
Uniprot O00221

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NFKBIE necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFKBIE immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NFKBIE GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0042994

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NFKBIE hsa:4794 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
NFKBIE hsa:4794 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKB2 NFKBIE 23180781 9135156 physical association two hybrid InnateDB
REL NFKBIE 23180781 9135156 9315679 physical association anti tag coimmunoprecipitation InnateDB
RELA NFKBIE 15722553 23180781 9135156 9315679 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NFKB1 NFKBIE 15722553 23180781 9315679 physical association anti tag coimmunoprecipitation,two hybrid,electrophoretic mobility shift assay InnateDB
PPP6R1 NFKBIE 16769727 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPP6R2 NFKBIE 16769727 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKB NFKBIE 10320352 23180781 physical association surface plasmon resonance InnateDB
XPO1 NFKBIE 11970947 23180781 physical association affinity chromatography technology InnateDB
BCL6 NFKBIE 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKBIE NFKB1 24243840 29145629 physical association inferred by curator Reactome
NFKBIE REL 24243840 29145629 physical association inferred by curator Reactome
NFKBIE RELA 24243840 29145629 physical association inferred by curator Reactome
NFKBIE CUL1 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
NFKBIE FBXW11 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
NFKBIE SKP1 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
NFKBIE BTRC 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
NFKBIE CHUK 10593898 29145629 9135156 9315679 9721103 9914500 enzymatic reaction inferred by curator Reactome
NFKBIE IKBKG 10593898 29145629 9135156 9315679 9721103 9914500 enzymatic reaction inferred by curator Reactome
NFKBIE IKBKB 10593898 29145629 9135156 9315679 9721103 9914500 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
FOXP3 NFKBIE 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NFKBIE 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 NFKBIE 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000033EBB8 NFKBIE 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NFKB2 NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE NFKB2 25361965 interaction type N/A PTMCode2
RELB NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE RELB 25361965 interaction type N/A PTMCode2
NFKB1 NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE NFKB1 25361965 interaction type N/A PTMCode2
NFKBIE REL 25361965 interaction type N/A PTMCode2
REL NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE IKBKG 25361965 interaction type N/A PTMCode2
IKBKG NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE CHUK 25361965 interaction type N/A PTMCode2
CHUK NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE RELA 25361965 interaction type N/A PTMCode2
RELA NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE PPP6C 25361965 interaction type N/A PTMCode2
PPP6C NFKBIE 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUBB NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VCP NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CALM1 NFKBIE 25348397 N/A tandem affinity purification ComPPI
SKP1 NFKBIE 14525934 14743216 25348397 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD
HSP90AB1 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
KBTBD7 NFKBIE 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
REL NFKBIE 10706725 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PRKDC NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HDAC4 NFKBIE 25348397 N/A physical interaction ComPPI
SFPQ NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ARHGEF2 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
JUP NFKBIE 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NCOR2 NFKBIE 25348397 N/A physical interaction ComPPI
DLD NFKBIE 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSP90AA1 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CDH1 NFKBIE 25348397 N/A physical interaction ComPPI
BTRC NFKBIE 25348397 N/A physical interaction ComPPI
HSPA5 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSMA5 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIA NFKBIE 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
C1QBP NFKBIE 14743216 21988832 24234451 25348397 physical association two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
CAD NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELA NFKBIE 14525934 14743216 21988832 24234451 25348397 9315679 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
EPRS1 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RARS1 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
XPO1 NFKBIE 11970947 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLTC NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CUL1 NFKBIE 14525934 14743216 25348397 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD
CHUK NFKBIE 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
HSPA9 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HIF1AN NFKBIE 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP6C NFKBIE 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PRKN NFKBIE 24234451 25348397 29128334 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HDAC5 NFKBIE 25348397 N/A physical interaction ComPPI
NFKB1 NFKBIE 14525934 14743216 24234451 25348397 9315679 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NFKB2 NFKBIE 14525934 14743216 24234451 25348397 9315679 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
IARS1 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSME3 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUBB4A NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRPF4 NFKBIE 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YEATS4 NFKBIE 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW11 NFKBIE 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
IL1A NFKBIE 10998424 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BAG2 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RUVBL2 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TIMM50 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE ANKHD1 14743216 21988832 24234451 25348397 physical association physical interaction,two hybrid array,tandem affinity purification ComPPI,IntAct
NFKBIE CDRT15P3 25348397 N/A physical interaction ComPPI
NFKBIE SKA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKBIE RELB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
NFKBIE ANKRD28 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
NFKBIE PPP6R2 14743216 16769727 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
NFKBIE PPP6R1 14743216 16769727 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
NFKBIE IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE HSPA1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE PPP6R3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE UACA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE ANKRD17 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PINK1 NFKBIE 24234451 25348397 29128334 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CALM2 NFKBIE 14743216 24234451 physical association tandem affinity purification IntAct
NFKBIE NFKBIE 14743216 24234451 physical association tandem affinity purification IntAct
PRKACA NFKBIE 27898060 9660950 N/A N/A OmniPath
NFKBIE NFKB1 12835716 14743216 15722553 27898060 9315679 inhibition N/A OmniPath
NFKB1 NFKBIE 14743216 15722553 27898060 9315679 N/A N/A OmniPath
NFKBIE NFE2L2 18241676 27898060 inhibition N/A OmniPath
NFKBIE RELA 10497169 14743216 15371334 15722553 21988832 27898060 9135156 9315679 9405619 9597130 N/A N/A OmniPath
NFKB2 NFKBIE 14743216 27898060 9135156 9315679 N/A N/A OmniPath
NFKBIE IKBKB 10320352 27898060 N/A N/A OmniPath
IKBKB NFKBIE 10320352 15218526 27898060 stimulant N/A OmniPath
NFKBIE PAG1 18241676 27898060 inhibition N/A OmniPath

Visualization










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