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GENE：MAPK8IP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAPK8IP3
FullNmae mitogen-activated protein kinase 8 interacting protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6884
EnsembleID ENSG00000138834
Uniprot Q9UPT6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAPK8IP3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAPK8IP3 GO:0000139,GO:0005078,GO:0005078,GO:0005515,GO:0005737,GO:0008432,GO:0016192,GO:0016192,GO:0019894,GO:0019894,GO:0030159,GO:0030424,GO:0030425,GO:0030426,GO:0031103,GO:0031410,GO:0043066,GO:0044297,GO:0046328,GO:0046330,GO:0048471,GO:0050821,GO:0061564,GO:0099641,GO:1904115

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAPK8IP3 hsa:23162 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ARF6 MAPK8IP3 19211056 23180781 physical association affinity chromatography technology InnateDB
MAPK8IP3 KLC1 19211056 23180781 physical association affinity chromatography technology InnateDB
MAPK8IP3 DCTN1 19211056 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK8IP3 MAP3K11 10629060 18988627 23331499 stimulation N/A SignaLink,SignaLink
MAPK8IP3 MAP2K7 10629060 23331499 stimulation N/A SignaLink,SignaLink
MAPK8IP3 MAP2K4 10523642 12189133 23331499 stimulation N/A SignaLink
MAPK8IP3 MAP3K1 10523642 23331499 stimulation N/A SignaLink
MAPK8IP3 MAPK10 10523642 12189133 15767678 23331499 stimulation N/A SignaLink
MAPK8IP3 MAPK9 10523642 10629060 11024282 12189133 15767678 23331499 stimulation N/A SignaLink
MAPK8IP3 MAPK8 10523642 10629060 12189133 15767678 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
MAPK8IP3 TLR4 20005715 interaction type N/A PSP
MAPK8IP3 MAP2K7 20005715 interaction type N/A PSP,SignaLink
MAPK8IP3 TLR2 20005715 interaction type N/A PSP
MAPK8IP3 RAF1 20005715 interaction type N/A PSP
MAPK8IP3 SRC 20005715 interaction type N/A PSP
MAPK8IP3 MAPK8 20005715 interaction type N/A PSP
MAPK8IP3 MAPK9 20005715 interaction type N/A PSP
MAPK8IP3 MAP2K4 20005715 interaction type N/A PSP
MAPK8IP3 MAPK10 20005715 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP2K1 20005715 interaction type N/A PSP
MAPK8IP3 PTK2 12226752 20005715 21071413 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP3K1 20005715 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP3K11 20005715 interaction type N/A PSP
MAPK8IP3 MAP3K5 12189133 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
MAPK8IP3 SRC 12226752 20005715 21071413 N/A N/A SignaLink
MAPK8IP3 MAP2K1 10523642 11044439 18988627 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 MAP2K4 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 MAP3K11 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 MAPK8 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 MAPK9 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 RAF1 10523642 11044439 18988627 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 TLR2 20005715 20005715 N/A N/A SignaLink
MAPK8IP3 TLR4 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAPK8IP3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MAPK8IP3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAPK8IP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003CF1AD MAPK8IP3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000033B548 MAPK8IP3 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000759B6A MAPK8IP3 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000221168 MAPK8IP3 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D814 MAPK8IP3 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BE495 MAPK8IP3 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000057A7C MAPK8IP3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 MAPK8IP3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B MAPK8IP3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 MAPK8IP3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 MAPK8IP3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171CD1 MAPK8IP3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005CC20C MAPK8IP3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 MAPK8IP3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000036AFF1 MAPK8IP3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ROCK1 MAPK8IP3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MAPK9 MAPK8IP3 10523642 10629060 11024282 12189133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LDLRAP1 MAPK8IP3 24234451 25348397 27107012 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
MAPK8 MAPK8IP3 10523642 10629060 12189133 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SRC MAPK8IP3 25348397 N/A physical interaction ComPPI
CASP3 MAPK8IP3 10629060 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NTRK1 MAPK8IP3 25348397 N/A physical interaction ComPPI
MAP2K4 MAPK8IP3 12189133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 MAPK8IP3 12189133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K1 MAPK8IP3 10523642 11044439 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8IP3 KLC1 11106729 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK8IP3 MAP3K11 10629060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK8IP3 MAPK10 10523642 10629060 12189133 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK8IP3 MAP2K7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAPK8IP3 MAPK8IP2 10629060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK8IP3 KLC2 11106729 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK8IP3 MAPK8IP1 10629060 14525934 16456539 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8IP3 TLR2 12941697 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK8IP3 TLR4 12941697 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK8IP3 TLR9 12941697 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK8IP3 RIC8A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAPK8IP3 RAF1 10523642 11044439 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK8IP3 COA8 25348397 N/A physical interaction ComPPI
MAPK8IP3 PTK2 25348397 N/A physical interaction ComPPI
MAPK8IP3 MAP3K1 25348397 N/A physical interaction ComPPI
MAPK8IP3 ALK 25348397 N/A physical interaction ComPPI
MAPK8IP3 KAT2A 25348397 N/A physical interaction ComPPI
MAPK8IP3 BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK8IP3 MAP2K3 25348397 N/A physical interaction ComPPI
MAPK8IP3 KIF1A 25348397 N/A physical interaction ComPPI
MAPK8IP3 RAD51 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP3 TNKS2 25348397 N/A physical interaction ComPPI
MAPK8IP3 SPAG9 25348397 N/A physical interaction ComPPI
MAPK8IP3 RCCD1 25348397 N/A physical interaction ComPPI
MAPK8IP3 SMCO1 25348397 N/A physical interaction ComPPI
MAPK8IP3 TNKS 25348397 N/A physical interaction ComPPI
MAPK8IP3 DCTN6 25348397 N/A physical interaction ComPPI
MAPK8IP3 WDR54 25348397 N/A physical interaction ComPPI
MAPK8IP3 DCTN4 25348397 N/A physical interaction ComPPI
MAPK8IP3 HNRNPL 25348397 N/A physical interaction ComPPI
MAPK8IP3 SULT4A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK8IP3 RAD51D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK8IP3 ZNF575 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ARL4D MAPK8IP3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ACTR10 MAPK8IP3 25348397 N/A physical interaction ComPPI
MAPK8IP3 MAPK8IP3 10629060 14525934 N/A experimental interaction detection HPRD
MAPK10 MAPK8IP3 10523642 10629060 12189133 15767678 27898060 stimulant N/A OmniPath
MAPK8IP3 MAPK10 10523642 10629060 12189133 15767678 27898060 stimulant N/A OmniPath
ROCK1 MAPK8IP3 15767678 19036714 27898060 stimulant N/A OmniPath
MAPK9 MAPK8IP3 10523642 10629060 11024282 12189133 15767678 27898060 stimulant N/A OmniPath
MAPK8IP3 MAPK9 10523642 10629060 11024282 12189133 15767678 27898060 stimulant N/A OmniPath
MAPK8IP3 MAP3K1 10523642 27898060 stimulant N/A OmniPath
MAPK8IP3 MAP2K4 10523642 1218913 12189133 27898060 stimulant N/A OmniPath
MAPK8IP3 MAP2K7 10629060 12189133 15767678 27898060 stimulant N/A OmniPath
MAPK8 MAPK8IP3 10523642 10629060 12189133 15767678 27898060 stimulant N/A OmniPath
MAPK8IP3 MAPK8 10523642 10629060 12189133 15767678 27898060 stimulant N/A OmniPath
MAPK8IP3 KLC1 11106729 19211056 27898060 N/A N/A OmniPath
ARF6 MAPK8IP3 19211056 27898060 N/A N/A OmniPath
MAPK8IP3 MAP3K11 10629060 27898060 stimulant N/A OmniPath
DCTN1 MAPK8IP3 19211056 27898060 N/A N/A OmniPath

Visualization










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