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GENE：RAPGEF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RAPGEF2
FullNmae Rap guanine nucleotide exchange factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16854
EnsembleID ENSG00000109756
Uniprot Q9Y4G8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RAPGEF2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAPGEF2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RAPGEF2 GO:0000165,GO:0001568,GO:0001764,GO:0005085,GO:0005085,GO:0005096,GO:0005509,GO:0005515,GO:0005737,GO:0005770,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0005923,GO:0006508,GO:0007186,GO:0007218,GO:0007264,GO:0007265,GO:0008285,GO:0010976,GO:0016020,GO:0016324,GO:0016324,GO:0019933,GO:0019933,GO:0019992,GO:0021591,GO:0021884,GO:0030033,GO:0030139,GO:0030139,GO:0030165,GO:0030552,GO:0031175,GO:0031547,GO:0031697,GO:0032092,GO:0032486,GO:0032991,GO:0035556,GO:0038180,GO:0043005,GO:0043025,GO:0043547,GO:0043547,GO:0043547,GO:0043950,GO:0045202,GO:0045860,GO:0048022,GO:0048167,GO:0048471,GO:0050699,GO:0050774,GO:0061028,GO:0070300,GO:0070374,GO:0071320,GO:0071321,GO:0071880,GO:0072659,GO:0090557,GO:1901888,GO:1990090,GO:2000481,GO:2000670,GO:2001214,GO:2001224

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RAPGEF2 hsa:9693 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RAPGEF2 hsa:9693 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
RAPGEF2 hsa:9693 path:hsa04530 Tight junction - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR RAPGEF2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RAPGEF2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RAPGEF2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RAPGEF2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RAPGEF2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RAPGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 RAPGEF2 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000237AF9 RAPGEF2 18185580 20371350 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000338542 RAPGEF2 20584899 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection TarBase
URS00003D5391 RAPGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D RAPGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E96DA RAPGEF2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 RAPGEF2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 RAPGEF2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000003FD55 RAPGEF2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000054DF42 RAPGEF2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004818BD RAPGEF2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 RAPGEF2 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCQ RAPGEF2 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 RAPGEF2 22135298 phosphorylation N/A PhosphoSite
IKBKB RAPGEF2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
ZNRD2 RAPGEF2 25348397 N/A physical interaction ComPPI
KIF5B RAPGEF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
LMNA RAPGEF2 25348397 N/A physical interaction ComPPI
XIAP RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZNF512B RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX5A RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAP2B RAPGEF2 10608883 10934204 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SREK1IP1 RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H4C1 RAPGEF2 25348397 N/A physical interaction ComPPI
HRAS RAPGEF2 10608844 24234451 25348397 N/A pull down ComPPI,IntAct
RACGAP1 RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SND1 RAPGEF2 25348397 N/A physical interaction ComPPI
FLNC RAPGEF2 25348397 N/A physical interaction ComPPI
SPP1 RAPGEF2 25348397 N/A physical interaction ComPPI
TTN RAPGEF2 25348397 N/A physical interaction ComPPI
SCYL2 RAPGEF2 25348397 N/A physical interaction ComPPI
YWHAZ RAPGEF2 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
UBC RAPGEF2 25348397 N/A physical interaction ComPPI
BTRC RAPGEF2 25348397 N/A physical interaction ComPPI
MAGI1 RAPGEF2 11168587 24234451 25348397 27898060 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
ERI3 RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA1A RAPGEF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HSPA1B RAPGEF2 25348397 N/A physical interaction,two hybrid fragment pooling approach ComPPI
MAGI3 RAPGEF2 25348397 N/A physical interaction ComPPI
PLEC RAPGEF2 25348397 N/A physical interaction ComPPI
HNRNPL RAPGEF2 25348397 N/A physical interaction ComPPI
RAP1A RAPGEF2 10608844 10608883 10934204 14525934 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
XPO1 RAPGEF2 25348397 N/A physical interaction ComPPI
NEDD4L RAPGEF2 21765395 24234451 25348397 N/A pull down ComPPI,IntAct
HTT RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB2 RAPGEF2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YAP1 RAPGEF2 24234451 24255178 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCI RAPGEF2 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTNNB1 RAPGEF2 10873669 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
WWOX RAPGEF2 25348397 N/A physical interaction ComPPI
PTPN13 RAPGEF2 25348397 N/A physical interaction ComPPI
USP11 RAPGEF2 25348397 N/A physical interaction ComPPI
NEDD4 RAPGEF2 11598133 21765395 24234451 24340059 25348397 27898060 N/A pull down,physical interaction ComPPI,IntAct,OmniPath
PRPSAP1 RAPGEF2 25348397 N/A physical interaction ComPPI
MAGI2 RAPGEF2 10548487 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,filter binding,in vitro,in vivo ComPPI,HPRD,IntAct
TRIM25 RAPGEF2 25348397 N/A physical interaction ComPPI
TNKS RAPGEF2 25348397 N/A physical interaction ComPPI
KIF5A RAPGEF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SEC62 RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRR1 RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MOB4 RAPGEF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FBXW11 RAPGEF2 25348397 N/A physical interaction ComPPI
MESD RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BDP1 RAPGEF2 25348397 N/A physical interaction ComPPI
KIF11 RAPGEF2 25348397 N/A physical interaction ComPPI
STOM RAPGEF2 25348397 N/A physical interaction ComPPI
KCTD5 RAPGEF2 25348397 N/A physical interaction ComPPI
KCTD17 RAPGEF2 25348397 N/A physical interaction ComPPI
SLC25A11 RAPGEF2 25348397 N/A physical interaction ComPPI
WDR91 RAPGEF2 25348397 N/A physical interaction ComPPI
TRMT6 RAPGEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF2 RALGDS 25348397 N/A physical interaction ComPPI
RAPGEF2 MT-ATP8 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RAPGEF2 EPB41L5 25348397 N/A physical interaction ComPPI
RAPGEF2 CTTNBP2 25348397 N/A physical interaction ComPPI
RAPGEF2 HMCN1 25348397 N/A physical interaction ComPPI
RAPGEF2 TJP1 25348397 N/A physical interaction ComPPI
RAPGEF2 LAP3 25348397 N/A physical interaction ComPPI
RAPGEF2 VSIG8 25348397 N/A physical interaction ComPPI
RAPGEF2 VPS50 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF2 UHRF1BP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF2 ANO3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF2 ATP5MK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF2 SP140L 25348397 N/A physical interaction ComPPI
H3-4 RAPGEF2 24234451 30021884 physical association cross-linking study IntAct
H1-5 RAPGEF2 24234451 30021884 physical association cross-linking study IntAct
PRKCQ RAPGEF2 18796635 27898060 stimulant N/A OmniPath
RAPGEF2 RAP2A 10608883 27898060 stimulant N/A OmniPath
MAGI2 RAPGEF2 10548487 27898060 N/A N/A OmniPath

Visualization










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