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GENE：RFFL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RFFL
FullNmae ring finger and FYVE like domain containing E3 ubiquitin protein ligase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24821
EnsembleID ENSG00000092871
Uniprot Q8WZ73

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RFFL necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFFL apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFFL apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RFFL GO:0002020,GO:0002039,GO:0005515,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0006511,GO:0006511,GO:0006915,GO:0010008,GO:0010762,GO:0010804,GO:0016020,GO:0019901,GO:0031625,GO:0032006,GO:0043161,GO:0043161,GO:0046872,GO:0055038,GO:0061630,GO:0061630,GO:0061630,GO:0070936,GO:0070936,GO:1901796,GO:1901797,GO:1902042,GO:1902042,GO:2001271,GO:2001271

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR RFFL 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RFFL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RFFL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RFFL 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RFFL 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RFFL 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RFFL 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RFFL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 RFFL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000013ABA3 RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D RFFL 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00005D986D RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F RFFL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 RFFL 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 RFFL 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE2D1 RFFL 25348397 N/A physical interaction ComPPI
SHC1 RFFL 25348397 N/A physical interaction ComPPI
USP7 RFFL 25348397 N/A physical interaction ComPPI
UBE2D2 RFFL 25348397 N/A physical interaction ComPPI
CASP8 RFFL 15069192 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
MDM2 RFFL 25348397 N/A physical interaction ComPPI
SFN RFFL 25348397 N/A in vivo ComPPI
RIPK1 RFFL 25348397 N/A physical interaction ComPPI
ATXN3 RFFL 25348397 N/A physical interaction ComPPI
STAM RFFL 25348397 N/A physical interaction ComPPI
UBE2D3 RFFL 25348397 N/A physical interaction ComPPI
TRIM25 RFFL 25348397 N/A physical interaction ComPPI
PRKD2 RFFL 25348397 N/A physical interaction ComPPI
RNF34 RFFL 25348397 N/A physical interaction ComPPI
UCHL5 RFFL 25348397 N/A physical interaction ComPPI
NEFH RFFL 25348397 N/A physical interaction ComPPI
OTUB2 RFFL 25348397 N/A physical interaction ComPPI
USP5 RFFL 25348397 N/A physical interaction ComPPI
USP28 RFFL 25348397 N/A physical interaction ComPPI
RFFL TP53 25348397 N/A physical interaction ComPPI
RFFL OTUB1 25348397 N/A physical interaction ComPPI
RFFL ESPL1 25348397 N/A physical interaction ComPPI

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