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GENE：MLKL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MLKL
FullNmae mixed lineage kinase domain like pseudokinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:26617
EnsembleID ENSG00000168404
Uniprot Q8NB16

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MLKL necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MLKL necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
MLKL immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MLKL cuproptosis 36118866 A cuproptosis-related score model incorporating TRAF2, TRADD, USP21, FAS, MLKL, TNFRSF10B, MAPK8, TRAF5, and RIPK3 was developed. retulator signature

Go Annotation:

GeneSymbol Go id
MLKL GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0007166,GO:0019901,GO:0030054,GO:0044877,GO:0051607,GO:0070207,GO:0070266,GO:0097527,GO:0097528,GO:0097528

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MLKL hsa:197259 path:hsa04217 Necroptosis - Homo sapiens (human)
MLKL hsa:197259 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
MLKL hsa:197259 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MLKL hsa:197259 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MLKL GLUD1 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
MLKL GLUL 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
MLKL PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
MLKL PYGL 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK1 MLKL 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 MLKL 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23180781 23377657 23612963 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
CFLAR MLKL 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866 interaction type N/A ACSN
FADD MLKL 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
MLKL FAF1 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
MLKL FASLG 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
MLKL FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
MLKL DAXX 26192618 interaction type N/A ACSN
TRAF2 MLKL 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR MLKL 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MLKL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MLKL 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MLKL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RIPK3 MLKL 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SNW1 MLKL 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PITPNA MLKL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP8 MLKL 25348397 N/A physical interaction ComPPI
RAD18 MLKL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAF2 MLKL 25348397 N/A physical interaction ComPPI
RIPK1 MLKL 25348397 N/A physical interaction ComPPI
RIPK3 MLKL 22265413 22265414 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,protein kinase assay ComPPI,IntAct
ANAPC11 MLKL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GLG1 MLKL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 MLKL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRA1 MLKL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLKL CDK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MLKL NDUFB7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MLKL THOC3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MLKL PARP16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLKL ZNF281 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RIPK3 MLKL 22265413 23612963 24703947 25801023 26184911 27898060 stimulant N/A OmniPath
IL15 MLKL 23612963 27898060 N/A N/A OmniPath

Visualization










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