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GENE：TLR3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLR3
FullNmae toll like receptor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11849
EnsembleID ENSG00000164342
Uniprot O15455

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLR3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR3 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TLR3 cuproptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TLR3 GO:0000139,GO:0001774,GO:0002224,GO:0002730,GO:0003725,GO:0003725,GO:0003725,GO:0004888,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005769,GO:0005789,GO:0005886,GO:0006972,GO:0007165,GO:0007250,GO:0007252,GO:0007254,GO:0008584,GO:0009597,GO:0010008,GO:0010008,GO:0010628,GO:0016020,GO:0031012,GO:0032722,GO:0032727,GO:0032728,GO:0032728,GO:0032728,GO:0032729,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0034138,GO:0034343,GO:0034346,GO:0035458,GO:0036020,GO:0038023,GO:0038187,GO:0042742,GO:0042802,GO:0043065,GO:0043123,GO:0043330,GO:0043331,GO:0045087,GO:0045671,GO:0045766,GO:0045944,GO:0046330,GO:0050729,GO:0051607,GO:0051607,GO:0060907,GO:0071260,GO:0071346,GO:0071360,GO:0071466,GO:0090594,GO:0097191,GO:0097527,GO:0098586,GO:1900017,GO:1901224

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLR3 hsa:7098 path:hsa04217 Necroptosis - Homo sapiens (human)
TLR3 hsa:7098 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05160 Hepatitis C - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05161 Hepatitis B - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05164 Influenza A - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
TLR3 hsa:7098 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MYD88 TLR3 12646618 23180781 physical association gst pull down InnateDB
TMED7 TLR3 14519765 23180781 physical association two hybrid InnateDB
TICAM1 TLR3 12471095 12539043 14519765 14982987 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TRAF6 TLR3 12609980 16115877 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 MAP3K7 12609980 16115877 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 TAB3 12609980 23180781 physical association anti tag coimmunoprecipitation InnateDB
RALBP1 TLR3 16115877 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 TLR3 17878161 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 TLR3 12672806 21220691 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF2 TLR3 12672806 23180781 physical association electrophoretic mobility supershift assay InnateDB
TLR3 NEU1 19430901 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3R1 TLR3 16858407 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 SRC 16858407 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 CD14 21078886 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 TOLLIP 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 TRAF3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 UNC93B1 22164301 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF8 TLR3 21220691 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
CASP8 TLR3 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 SCARF1 23180781 25641411 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
PIK3R1 TLR3 20005715 interaction type N/A PSP,SignaLink
TICAM1 TLR3 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
YBX1 TLR3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TLR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TLR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TLR3 22310660 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 TLR3 22208359 trascriptional regulation,stimulation inferred by curator TFlink
IRF8 TLR3 21220691 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TLR3 16423052 20658750 trascriptional regulation,stimulation inferred by curator TFlink
RELA TLR3 16423052 20658750 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 TLR3 16628196 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000024B619 TLR3 25008898 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E3523 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 TLR3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D TLR3 25327529 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SRC TLR3 22135298 phosphorylation N/A PhosphoSite
EGFR TLR3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TRAF6 TLR3 12609980 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SYK TLR3 25348397 N/A physical interaction ComPPI
PIK3R1 TLR3 16858407 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRC TLR3 16858407 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
CASP8 TLR3 25348397 N/A physical interaction ComPPI
TRAF3 TLR3 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIGLEC7 TLR3 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
FADD TLR3 25348397 N/A physical interaction ComPPI
CSK TLR3 14525934 16858407 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP2K6 TLR3 25348397 N/A physical interaction ComPPI
CHEK2 TLR3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK2 TLR3 25348397 N/A physical interaction ComPPI
RIPK1 TLR3 25348397 N/A physical interaction ComPPI
SIGLEC10 TLR3 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
MAP3K7 TLR3 25348397 N/A physical interaction ComPPI
TAB2 TLR3 25348397 N/A physical interaction ComPPI
MBL2 TLR3 24234451 24530528 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
MYD88 TLR3 12646618 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TOLLIP TLR3 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TICAM2 TLR3 14519765 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
TBK1 TLR3 25348397 N/A physical interaction ComPPI
BIRC2 TLR3 25348397 N/A physical interaction ComPPI
BIRC3 TLR3 25348397 N/A physical interaction ComPPI
RNF216 TLR3 14525934 15107846 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TLR3 TICAM1 12539043 14525934 14982987 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
TLR3 CD14 14525934 16473828 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TLR3 TRIM69 25348397 N/A physical interaction ComPPI
TLR3 HLA-DRA 24600555 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TLR3 WDFY1 25348397 N/A physical interaction ComPPI
TLR3 IRGM 25348397 N/A physical interaction ComPPI
TLR3 RNF31 25348397 N/A physical interaction ComPPI
TLR3 SHARPIN 25348397 N/A physical interaction ComPPI
TLR3 RBCK1 25348397 N/A physical interaction ComPPI
TLR3 IKBKG 25348397 N/A physical interaction ComPPI
TLR3 TRIL 21911501 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct,OmniPath
TLR3 UNC93B1 22164301 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TLR3 SIGLEC9 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
SIGLEC5 TLR3 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR3 TLR3 14525934 15107846 18172197 23155421 24234451 25217833 physical association cosedimentation in solution,molecular sieving,nuclear magnetic resonance,tox-r dimerization assay,two hybrid HPRD,IntAct
TLR3 SCARF1 25641411 27898060 N/A N/A OmniPath
TLR3 SRC 16858407 27898060 N/A N/A OmniPath
SRC TLR3 12509442 16858407 27898060 N/A N/A OmniPath
EGFR TLR3 22810896 27898060 N/A N/A OmniPath
TLR3 MAP3K7 12609980 16115877 27898060 stimulant N/A OmniPath
TLR3 TICAM1 12471095 12539043 14519765 14751757 14982987 15932500 16410796 25736436 27898060 stimulant N/A OmniPath
TICAM1 TLR3 12471095 12539043 14519765 14751757 14982987 15932500 25736436 27898060 N/A N/A OmniPath
TLR3 TRAF6 12609980 16115877 21911421 27898060 stimulant N/A OmniPath
MYD88 TLR3 12646618 27898060 N/A N/A OmniPath
TLR3 PIK3R1 16858407 27898060 N/A N/A OmniPath
CD14 TLR3 16473828 21078886 27898060 stimulant N/A OmniPath
TLR3 RALBP1 16115877 27898060 N/A N/A OmniPath
RPS6KB1 TLR3 12509442 27898060 N/A N/A OmniPath
TLR3 TRAF3 21903422 27898060 N/A N/A OmniPath
UNC93B1 TLR3 22164301 27898060 N/A N/A OmniPath
TLR3 TMED7 14519765 27898060 N/A N/A OmniPath
TLR3 IRAK2 17878161 27898060 N/A N/A OmniPath
IRAK2 TLR3 17878161 27898060 N/A N/A OmniPath
TLR3 TAB3 12609980 27898060 stimulant N/A OmniPath
TLR3 TOLLIP 21903422 27898060 N/A N/A OmniPath
NEU1 TLR3 19430901 27898060 N/A N/A OmniPath

Visualization










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