Gene Information gene info

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GENE：GLUD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GLUD1
FullNmae glutamate dehydrogenase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4335
EnsembleID ENSG00000148672
Uniprot P00367

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GLUD1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GLUD1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GLUD1 GO:0004352,GO:0004352,GO:0004353,GO:0004354,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005739,GO:0005759,GO:0005783,GO:0006537,GO:0006538,GO:0006538,GO:0006541,GO:0021762,GO:0032024,GO:0042803,GO:0043531,GO:0070403,GO:0070728,GO:0072350

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GLUD1 hsa:2746 path:hsa00220 Arginine biosynthesis - Homo sapiens (human)
GLUD1 hsa:2746 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
GLUD1 hsa:2746 path:hsa00910 Nitrogen metabolism - Homo sapiens (human)
GLUD1 hsa:2746 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GLUD1 hsa:2746 path:hsa01200 Carbon metabolism - Homo sapiens (human)
GLUD1 hsa:2746 path:hsa04217 Necroptosis - Homo sapiens (human)
GLUD1 hsa:2746 path:hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GLUD1 PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
GLUD1 PYGL 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
GLUL GLUD1 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
MLKL GLUD1 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK1 GLUD1 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK3 GLUD1 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR GLUD1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 GLUD1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
FOXP3 GLUD1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GLUD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 GLUD1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A GLUD1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 GLUD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 GLUD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA GLUD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 GLUD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A4ABF GLUD1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 GLUD1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000061E50F GLUD1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 GLUD1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001D69F6 GLUD1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GLUD1 GLUD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 GLUD1 14525934 14760703 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FASTKD3 GLUD1 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TRAF6 GLUD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
E2F6 GLUD1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
LSM1 GLUD1 25348397 N/A physical interaction ComPPI
MCM2 GLUD1 25348397 N/A physical interaction ComPPI
BIRC8 GLUD1 25348397 N/A physical interaction ComPPI
JUN GLUD1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PTPN22 GLUD1 25348397 N/A physical interaction ComPPI
U2AF2 GLUD1 25348397 N/A physical interaction ComPPI
CUL3 GLUD1 25348397 N/A physical interaction ComPPI
NTRK1 GLUD1 25348397 N/A physical interaction ComPPI
VTN GLUD1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ILK GLUD1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
STAT5A GLUD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DUSP16 GLUD1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PARD6A GLUD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NR4A1 GLUD1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TFDP1 GLUD1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
MAP3K14 GLUD1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ASGR2 GLUD1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK5 GLUD1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CUL7 GLUD1 25348397 N/A physical interaction ComPPI
HDAC5 GLUD1 25348397 N/A physical interaction ComPPI
PDK1 GLUD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ELAVL1 GLUD1 25348397 N/A physical interaction ComPPI
GLUD1 GOT2 14525934 25348397 27898060 3997814 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
GLUD1 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GLUD1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
GLUD1 CRP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GLUD1 ORM1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GLUD1 HPX 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GLUD1 SEC62 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GLUD1 DCP2 25348397 N/A physical interaction ComPPI
GLUD1 KLHL29 25348397 N/A physical interaction ComPPI
GLUD1 FUS 25348397 N/A physical interaction ComPPI
GLUD1 GLUD2 25348397 N/A physical interaction ComPPI
GLUD1 UNK 25348397 N/A physical interaction ComPPI
GLUD1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GLUD1 POU5F1 25348397 N/A physical interaction ComPPI
GLUD1 HSD17B10 25348397 N/A physical interaction ComPPI
GLUD1 CRBN 25348397 N/A physical interaction ComPPI
GLUD1 HYPK 25348397 N/A physical interaction ComPPI
GLUD1 ZNF746 25348397 N/A physical interaction ComPPI
GLUD1 KLHL22 25348397 N/A physical interaction ComPPI
GLUD1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GLUD1 L3MBTL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
GLUD1 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
GLUD1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
GLUD1 PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
GLUD1 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLUD1 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLUD1 HSPD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AURKAIP1 GLUD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 GLUD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPN23 GLUD1 24234451 25348397 28330616 association pull down ComPPI,IntAct
TRMT61B GLUD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLUD1 GLUD1 12653548 14525934 N/A experimental interaction detection HPRD
RIPK3 GLUD1 19632174 27898060 stimulant N/A OmniPath

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