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GENE：GLUD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GLUD2
FullNmae glutamate dehydrogenase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4336
EnsembleID ENSG00000182890
Uniprot P49448

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GLUD2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GLUD2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GLUD2 GO:0004352,GO:0004352,GO:0004353,GO:0004354,GO:0005525,GO:0005739,GO:0005739,GO:0005759,GO:0006536,GO:0006537,GO:0006538,GO:0006538,GO:0043531,GO:0070728

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GLUD2 hsa:2747 path:hsa00220 Arginine biosynthesis - Homo sapiens (human)
GLUD2 hsa:2747 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
GLUD2 hsa:2747 path:hsa00910 Nitrogen metabolism - Homo sapiens (human)
GLUD2 hsa:2747 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GLUD2 hsa:2747 path:hsa01200 Carbon metabolism - Homo sapiens (human)
GLUD2 hsa:2747 path:hsa04217 Necroptosis - Homo sapiens (human)
GLUD2 hsa:2747 path:hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA1 GLUD2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GLUD2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 GLUD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GLUD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GLUD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB GLUD2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D5659 GLUD2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC GLUD2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000061E50F GLUD2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 GLUD2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MCM2 GLUD2 25348397 N/A physical interaction ComPPI
TOM1L1 GLUD2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MYC GLUD2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
RNF2 GLUD2 25348397 N/A physical interaction ComPPI
CLPP GLUD2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
GLUD1 GLUD2 25348397 N/A physical interaction ComPPI
ATF2 GLUD2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SHMT2 GLUD2 25348397 N/A physical interaction ComPPI
MED4 GLUD2 25348397 N/A physical interaction ComPPI
GLUD2 MOV10 25348397 N/A physical interaction ComPPI
GLUD2 CRBN 25348397 N/A physical interaction ComPPI
GLUD2 KLHL22 25348397 N/A physical interaction ComPPI
GLUD2 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct

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