GENE：ALOX15
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ALOX15 |
| FullNmae | arachidonate 15-lipoxygenase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:433 |
| EnsembleID | ENSG00000161905 |
| Uniprot | P16050 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ALOX15 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ALOX15 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| ALOX15 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ALOX15 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ALOX15 | GO:0001503,GO:0002820,GO:0004052,GO:0004052,GO:0005506,GO:0005515,GO:0005546,GO:0005811,GO:0005829,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006629,GO:0006646,GO:0006954,GO:0009898,GO:0010811,GO:0016020,GO:0016165,GO:0019369,GO:0019369,GO:0019369,GO:0019372,GO:0019372,GO:0019372,GO:0019395,GO:0030282,GO:0030838,GO:0034440,GO:0034976,GO:0035358,GO:0035963,GO:0042060,GO:0042759,GO:0043277,GO:0043651,GO:0043651,GO:0050473,GO:0050473,GO:0050473,GO:0050473,GO:0050727,GO:0051122,GO:0051122,GO:0070374,GO:0071277,GO:1901074,GO:2001303 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ALOX15 | hsa:246 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| ALOX15 | hsa:246 | path:hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| ALOX15 | hsa:246 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ALOX15 | hsa:246 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| ALOX15 | hsa:246 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
| ALOX15 | hsa:246 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| ALOX15 | hsa:246 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYC | ALOX15 | 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027 26192618 | interaction type | N/A | ACSN |
| ALOX15 | STAT6 | 11509556 23180781 | physical association | affinity chromatography technology,anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | ALOX15 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| XRCC5 | ALOX15 | 11196700 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| PRDM14 | ALOX15 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ALOX15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ALOX15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ALOX15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ALOX15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ALOX15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREBBP | ALOX15 | 12517954 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EP300 | ALOX15 | 12517954 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC1 | ALOX15 | 19198625 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MTA1 | ALOX15 | 19198625 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ALOX15 | 16320347 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT6 | ALOX15 | 10657944 12517954 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | ALOX15 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004DA9DB | ALOX15 | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS000023BE29 | ALOX15 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000527B00 | ALOX15 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | ALOX15 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | ALOX15 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | ALOX15 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | ALOX15 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DABC0 | ALOX15 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | ALOX15 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | ALOX15 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKDC | ALOX15 | 25348397 | N/A | physical interaction | ComPPI |
| PEBP1 | ALOX15 | 21831839 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DDX19B | ALOX15 | 25348397 | N/A | physical interaction | ComPPI |
| KSR1 | ALOX15 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TIMM29 | ALOX15 | 25348397 | N/A | physical interaction | ComPPI |