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GENE：PPIA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPIA
FullNmae peptidylprolyl isomerase A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9253
EnsembleID ENSG00000196262
Uniprot P62937

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPIA necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPIA necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PPIA ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPIA apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPIA apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPIA GO:0000413,GO:0000413,GO:0001933,GO:0001934,GO:0003723,GO:0003755,GO:0003755,GO:0003755,GO:0005178,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005925,GO:0006457,GO:0006457,GO:0006469,GO:0006915,GO:0006915,GO:0016018,GO:0016018,GO:0016018,GO:0016020,GO:0019076,GO:0030168,GO:0030593,GO:0030595,GO:0031982,GO:0032148,GO:0032873,GO:0032991,GO:0034389,GO:0034599,GO:0034774,GO:0035307,GO:0042118,GO:0043410,GO:0045069,GO:0045069,GO:0045070,GO:0046790,GO:0050714,GO:0051082,GO:0051092,GO:0060352,GO:0061944,GO:0070062,GO:0070062,GO:0070527,GO:1902176,GO:1903901,GO:1904399,GO:1904813,GO:2001233

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPIA hsa:5478 path:hsa03250 Viral life cycle - HIV-1 - Homo sapiens (human)
PPIA hsa:5478 path:hsa04217 Necroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP PPIA 16049941 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPIA CXCR4 17991743 23180781 physical association anti tag coimmunoprecipitation InnateDB
HNRNPA2B1 PPIA 17991743 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 PPIA 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PPIA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PPIA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC PPIA 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPIA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EEF5F PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002971AB PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000512C88 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AD002 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 PPIA 23622248 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS000019907A PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000001EB3 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001938D9 PPIA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006DA05 PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000018E72A PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000045E0EC PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000258D51 PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000030F801 PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000215483 PPIA 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000065FDF PPIA 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D PPIA 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F PPIA 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E PPIA 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 PPIA 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005F9738 PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002E177F PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000585553 PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000250A40 PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000049FAE8 PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDA4 PPIA 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BSG PPIA 25361965 interaction type N/A PTMCode2
PPIA BSG 25361965 interaction type N/A PTMCode2
YY1 PPIA 25361965 interaction type N/A PTMCode2
PPIA YY1 25361965 interaction type N/A PTMCode2
PIN1 PPIA 25361965 interaction type N/A PTMCode2
PPIA PIN1 25361965 interaction type N/A PTMCode2
PRLR PPIA 25361965 interaction type N/A PTMCode2
PPIA PRLR 25361965 interaction type N/A PTMCode2
PPP3R1 PPIA 25361965 interaction type N/A PTMCode2
PPIA PPP3R1 25361965 interaction type N/A PTMCode2
PPP3CA PPIA 25361965 interaction type N/A PTMCode2
PPIA PPP3CA 25361965 interaction type N/A PTMCode2
PPIA PPIA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 PPIA 25348397 N/A physical interaction ComPPI
LDHB PPIA 25348397 N/A physical interaction ComPPI
LDHA PPIA 25348397 N/A physical interaction ComPPI
ANXA1 PPIA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCNA PPIA 20849852 24234451 25348397 physical association far western blotting,physical interaction ComPPI,IntAct
CFL1 PPIA 25348397 N/A physical interaction ComPPI
GABARAPL2 PPIA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KEAP1 PPIA 25348397 N/A physical interaction ComPPI
MCM2 PPIA 25348397 N/A physical interaction ComPPI
MAP1LC3B PPIA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CRK PPIA 25348397 N/A fluorescent resonance energy transfer,isothermal titration calorimetry,nuclear magnetic resonance,nuclear magnetic resonance,physical interaction ComPPI
RAB10 PPIA 25348397 N/A physical interaction ComPPI
DDIT4L PPIA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ERRFI1 PPIA 25348397 N/A physical interaction ComPPI
PRLR PPIA 12668872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ZYX PPIA 11423549 24234451 25348397 physical association two hybrid ComPPI,IntAct
GRB2 PPIA 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN PPIA 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
RB1 PPIA 12210730 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
COPS5 PPIA 25348397 N/A physical interaction ComPPI
LIG4 PPIA 25348397 N/A physical interaction ComPPI
ITK PPIA 11830645 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
U2AF2 PPIA 25348397 N/A physical interaction ComPPI
RBM4 PPIA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAXIP1 PPIA 25348397 N/A physical interaction ComPPI
CUL3 PPIA 25348397 N/A physical interaction ComPPI
YWHAZ PPIA 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
UBE2N PPIA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 PPIA 25348397 N/A physical interaction ComPPI
ENO1 PPIA 25348397 N/A physical interaction ComPPI
PIR PPIA 25348397 N/A physical interaction ComPPI
PEBP1 PPIA 25348397 N/A physical interaction ComPPI
CD247 PPIA 24234451 24502978 25348397 association pull down ComPPI,IntAct
DUSP4 PPIA 25348397 N/A physical interaction ComPPI
TERT PPIA 25348397 N/A physical interaction ComPPI
VDAC1 PPIA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EWSR1 PPIA 25348397 N/A physical interaction ComPPI
UTRN PPIA 18838687 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA2 PPIA 25348397 N/A physical interaction ComPPI
USP4 PPIA 25348397 N/A physical interaction ComPPI
ARRB1 PPIA 17620599 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HUWE1 PPIA 25348397 N/A physical interaction ComPPI
SRPK1 PPIA 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
NEDD8 PPIA 25348397 N/A physical interaction ComPPI
CUL4B PPIA 25348397 N/A physical interaction ComPPI
ARRB2 PPIA 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 PPIA 25348397 N/A physical interaction ComPPI
YY1 PPIA 25348397 N/A physical interaction ComPPI
CUL1 PPIA 25348397 N/A physical interaction ComPPI
CPLX1 PPIA 25348397 N/A physical interaction ComPPI
JAK2 PPIA 12668872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GABARAP PPIA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP1LC3A PPIA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VCAM1 PPIA 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 PPIA 25348397 N/A physical interaction ComPPI
DNM1L PPIA 24234451 25348397 26496610 29128334 association anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
RAD23B PPIA 25348397 N/A physical interaction ComPPI
IGBP1 PPIA 25348397 N/A physical interaction ComPPI
STX3 PPIA 25348397 N/A physical interaction ComPPI
LYST PPIA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL7 PPIA 25348397 N/A physical interaction ComPPI
HDAC5 PPIA 25348397 N/A physical interaction ComPPI
PSMD4 PPIA 25348397 N/A physical interaction ComPPI
SUPT5H PPIA 14525934 16169070 24234451 25348397 physical association two hybrid,pull down,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPIA PRSS23 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PPIA PRR13 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PPIA CD99 14525934 15388255 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PPIA S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPIA PTPRN 14525934 16273344 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
PPIA PPP3CA 25348397 N/A physical interaction ComPPI
PPIA H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA POU5F1 25348397 N/A physical interaction ComPPI
PPIA ELAVL1 25348397 N/A physical interaction ComPPI
PPIA HNRNPA1 25348397 N/A physical interaction ComPPI
PPIA CHMP4A 25348397 N/A physical interaction ComPPI
PPIA AKT1 25348397 N/A physical interaction ComPPI
PPIA APP 16049941 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA TAGLN2 25348397 N/A physical interaction ComPPI
PPIA SNX3 25348397 N/A physical interaction ComPPI
PPIA SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA PTMA 25348397 N/A physical interaction ComPPI
PPIA FN1 25348397 N/A physical interaction ComPPI
PPIA RAD52 19338310 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA ESR1 25348397 N/A physical interaction ComPPI
PPIA SRPK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PPIA RPL23A 25348397 N/A physical interaction ComPPI
PPIA FUS 25348397 N/A physical interaction ComPPI
PPIA TCF4 25348397 N/A physical interaction ComPPI
PPIA LNX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PPIA NOTCH3 25348397 N/A physical interaction ComPPI
PPIA OBSL1 25348397 N/A physical interaction ComPPI
PPIA CBFB 25348397 N/A physical interaction ComPPI
PPIA CRIP1 25348397 N/A physical interaction ComPPI
PPIA DDX46 25348397 N/A physical interaction ComPPI
PPIA HEATR5A 25348397 N/A physical interaction ComPPI
PPIA HSPE1 25348397 N/A physical interaction ComPPI
PPIA KYNU 25348397 N/A physical interaction ComPPI
PPIA PCK2 25348397 N/A physical interaction ComPPI
PPIA N4BP2L2 25348397 N/A physical interaction ComPPI
PPIA ANXA7 25348397 N/A physical interaction ComPPI
PPIA ALDH7A1 25348397 N/A physical interaction ComPPI
PPIA GART 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA RAB5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA CSDE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA MKNK1 25348397 N/A physical interaction ComPPI
PPIA BCL7B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA ZER1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA DMAC2L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA PKN3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA EPB41L4B 25348397 N/A physical interaction ComPPI
PPIA COPS7B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA DCAF15 25348397 N/A physical interaction ComPPI
PPIA PEDS1 25348397 N/A physical interaction ComPPI
PPIA RC3H1 25348397 N/A physical interaction ComPPI
PPIA DUSP28 25348397 N/A physical interaction ComPPI
PPIA DUSP9 25348397 N/A physical interaction ComPPI
PPIA COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA TRIM25 25348397 N/A physical interaction ComPPI
PPIA G3BP1 25348397 N/A physical interaction ComPPI
PPIA GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPIA AIFM1 14716299 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
PPIA UBE2V1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP3R1 PPIA 25348397 N/A physical interaction ComPPI
ATF2 PPIA 22304920 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPIA BSG 11943775 14525934 N/A experimental interaction detection,two hybrid HPRD
PPIA PPIA 12167617 14525934 N/A experimental interaction detection HPRD
METTL14 PPIA 24234451 29507755 association anti tag coimmunoprecipitation IntAct
PPIF PPIA 24234451 30021884 physical association cross-linking study IntAct
PPIA BPY2 24234451 30021884 physical association cross-linking study IntAct
PPIA MACO1 24234451 30021884 physical association cross-linking study IntAct
KLB PPIA 24234451 30021884 physical association cross-linking study IntAct
L1TD1 PPIA 24234451 25702638 association anti bait coimmunoprecipitation IntAct
CXCR4 PPIA 17991743 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C2206 PPIA 27087310 direct interaction,inhibition N/A NPInter

Visualization










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