GENE：CAPN2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CAPN2 |
| FullNmae | calpain 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1479 |
| EnsembleID | ENSG00000162909 |
| Uniprot | P17655 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CAPN2 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CAPN2 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CAPN2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CAPN2 | apoptosis | 40180900 | Transcriptome sequencing revealed that the expression of apoptosis-related genes (Capn1, Capn2, Bax, Aifm1, Caspase 3, Map3k5, Itpr1 and Fas) was down-regulated in spermatocytes of cryptorchid Trpv1-/- mice. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CAPN2 | GO:0000785,GO:0001666,GO:0001824,GO:0004198,GO:0004198,GO:0004198,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0006508,GO:0006508,GO:0006508,GO:0007520,GO:0007565,GO:0008092,GO:0008234,GO:0009612,GO:0009897,GO:0010666,GO:0016540,GO:0019899,GO:0030425,GO:0030864,GO:0031143,GO:0032675,GO:0035458,GO:0042542,GO:0043025,GO:0044877,GO:0045121,GO:0048266,GO:0051493,GO:0051603,GO:0070062,GO:0071222,GO:0071230,GO:0097038,GO:0110158,GO:1901741,GO:2001247 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CAPN2 | hsa:824 | path:hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| CAPN2 | hsa:824 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CAPN2 | BID | 11404357 11940658 17264306 18469004 21887410 23242420 26192618 | interaction type | N/A | ACSN |
| HTRA2 | CAPN2 | 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005 26192618 | interaction type | N/A | ACSN |
| XIAP | CAPN2 | 11583623 12815069 12835328 21887410 23242420 26192618 | interaction type | N/A | ACSN |
| CAPN2 | BAX | 21887410 23242420 26192618 | interaction type | N/A | ACSN |
| PTPN1 | CAPN2 | 23180781 9470132 | cleavage reaction | protease assay | InnateDB |
| MAPK1 | CAPN2 | 14993287 23180781 | phosphorylation reaction | protein kinase assay | InnateDB |
| ATG5 | CAPN2 | 16998475 23180781 | cleavage reaction | protease assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CAPN2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | CAPN2 | 19376833 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ESR2 | CAPN2 | 19376833 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | CAPN2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CAPN2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | CAPN2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | CAPN2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CAPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | CAPN2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK3 | CAPN2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK1 | CAPN2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CAPN2 | CDK5R1 | 25361965 | interaction type | N/A | PTMCode2 |
| CDK5R1 | CAPN2 | 25361965 | interaction type | N/A | PTMCode2 |
| CAPN2 | CAST | 25361965 | interaction type | N/A | PTMCode2 |
| CAST | CAPN2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | CAPN2 | 10671558 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CDK5R1 | CAPN2 | 10830966 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| TUFM | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK1 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| SUMO1 | CAPN2 | 23395904 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| NTRK1 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| KNG1 | CAPN2 | 14525934 25348397 3038169 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| F2RL1 | CAPN2 | 10978167 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PTPN1 | CAPN2 | 14525934 24234451 25348397 9407132 | enzymatic reaction | experimental interaction detection,protease assay,in vitro | ComPPI,HPRD,IntAct |
| PDIA4 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPT | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| NFKBIA | CAPN2 | 14525934 25348397 9873017 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CFTR | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| ECT2 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| PAFAH1B1 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| GRK2 | CAPN2 | 12130691 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NAE1 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| SOX2 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| ZDHHC17 | CAPN2 | 24234451 24705354 25348397 | physical association | two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| YWHAE | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| JAK3 | CAPN2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MSN | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| ATXN3 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| BCL2 | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRN | CAPN2 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | GAS2 | 11387205 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| CAPN2 | CAPNS2 | 11853546 14525934 15590481 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CAPN2 | NMT1 | 14525934 16530191 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| CAPN2 | BID | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | HNRNPA1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | CEBPA | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | ASNS | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | ATIC | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | ALDH7A1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | GMDS | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | HK1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | STK26 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | NSFL1C | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | PCYT2 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | TATDN1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | TWF2 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | UBA3 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | PAPSS1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | PLPBP | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | PTMA | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | SNRPE | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | TUBB2A | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | UBXN1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | DCP2 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | ATG5 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | DNASE2B | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | B3GNT2 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | MAN2A2 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | CHORDC1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CAPN2 | FBXL12 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | DUSP19 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | CAPN1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | LSP1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | GNS | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | PSG8 | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | CAST | 18519038 24234451 25348397 | physical association | nuclear magnetic resonance | ComPPI,IntAct |
| CAPN2 | TNS1 | 11023826 14525934 24234451 25348397 | cleavage reaction | experimental interaction detection,protease assay | ComPPI,HPRD,IntAct |
| CAPN2 | DUX4 | 24234451 25348397 26816005 | association | pull down | ComPPI,IntAct |
| CAPN2 | KSR1 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CAPNS1 | CAPN2 | 10639123 10666632 11517928 11673052 14525934 18519038 24234451 25348397 | physical association | experimental interaction detection,nuclear magnetic resonance,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| NUDCD1 | CAPN2 | 24234451 29021621 | association | anti tag coimmunoprecipitation | IntAct |
| PRKACA | CAPN2 | 11909964 27898060 | inhibition,stimulant | N/A | OmniPath |
| CAPNS1 | CAPN2 | 10639123 10666632 11517928 11673052 16597616 27898060 | stimulant | N/A | OmniPath |
| CAPN2 | BCL2L1 | 12000759 27898060 | inhibition | N/A | OmniPath |
| CAPN2 | BID | 12000759 27898060 | stimulant | N/A | OmniPath |
| CAPN2 | CASP9 | 10671558 27898060 | N/A | N/A | OmniPath |
| CAPN2 | BCL2 | 12000759 27898060 | inhibition | N/A | OmniPath |
| CAPN2 | GSK3A | 25969760 27898060 | stimulant | N/A | OmniPath |
| MAPK3 | CAPN2 | 14993287 27898060 | stimulant | N/A | OmniPath |
| MAPK1 | CAPN2 | 11909964 14993287 27898060 | stimulant | N/A | OmniPath |
| CAPN2 | MAPT | 25969760 27898060 | inhibition | N/A | OmniPath |
| CAPN2 | ATG5 | 16998475 27898060 | inhibition,stimulant | N/A | OmniPath |
| CAPN2 | GSK3B | 25969760 27898060 | stimulant | N/A | OmniPath |
| CAPN2 | CDK5R1 | 10830966 25969760 27898060 | stimulant | N/A | OmniPath |
| CAPN2 | GRK2 | 12130691 27898060 | N/A | N/A | OmniPath |
| CAST | CAPN2 | 25969760 27898060 | inhibition | N/A | OmniPath |