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GENE：JAK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol JAK2
FullNmae Janus kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6192
EnsembleID ENSG00000096968
Uniprot O60674

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
JAK2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
JAK2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
JAK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
JAK2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
JAK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
JAK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
JAK2 GO:0000791,GO:0001774,GO:0002250,GO:0004672,GO:0004713,GO:0004713,GO:0004713,GO:0004713,GO:0004715,GO:0004715,GO:0005102,GO:0005131,GO:0005131,GO:0005143,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0005901,GO:0005925,GO:0006338,GO:0006366,GO:0006468,GO:0006915,GO:0006919,GO:0006955,GO:0007165,GO:0007167,GO:0007186,GO:0007204,GO:0007259,GO:0007259,GO:0007259,GO:0007260,GO:0007260,GO:0007498,GO:0008285,GO:0008631,GO:0010572,GO:0010667,GO:0010811,GO:0014075,GO:0018108,GO:0019221,GO:0019221,GO:0019221,GO:0019221,GO:0019897,GO:0019901,GO:0020037,GO:0022408,GO:0030041,GO:0030154,GO:0030218,GO:0030218,GO:0030335,GO:0030526,GO:0031103,GO:0031234,GO:0031234,GO:0031702,GO:0031904,GO:0031959,GO:0032024,GO:0032496,GO:0032729,GO:0032731,GO:0032740,GO:0032760,GO:0032819,GO:0033130,GO:0033194,GO:0033209,GO:0034050,GO:0034612,GO:0035166,GO:0035401,GO:0035556,GO:0035556,GO:0035722,GO:0036016,GO:0038043,GO:0038065,GO:0038156,GO:0038157,GO:0042022,GO:0042102,GO:0042169,GO:0042307,GO:0042393,GO:0042531,GO:0042802,GO:0042976,GO:0042981,GO:0043392,GO:0043410,GO:0043524,GO:0043548,GO:0043560,GO:0043687,GO:0045121,GO:0045348,GO:0045428,GO:0045429,GO:0045597,GO:0045944,GO:0046425,GO:0046427,GO:0046677,GO:0046777,GO:0046872,GO:0048008,GO:0050727,GO:0050731,GO:0050804,GO:0051142,GO:0051142,GO:0051428,GO:0051770,GO:0051897,GO:0060333,GO:0060333,GO:0060391,GO:0060396,GO:0060397,GO:0060397,GO:0060399,GO:0061180,GO:0070102,GO:0070665,GO:0070671,GO:0070757,GO:0071222,GO:0071549,GO:0072536,GO:0097191,GO:0097296,GO:0098586,GO:0098794,GO:0098978,GO:0120162,GO:1901731,GO:1902728,GO:1904037,GO:1904707,GO:1905539,GO:2000273,GO:2000318,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
JAK2 hsa:3717 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04148 Efferocytosis - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04217 Necroptosis - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
JAK2 hsa:3717 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05140 Leishmaniasis - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05152 Tuberculosis - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05161 Hepatitis B - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05164 Influenza A - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05200 Pathways in cancer - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
JAK2 hsa:3717 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JAK1 JAK2 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26192618 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217 interaction type N/A ACSN
JAK2 IFNGR1 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26192618 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217 interaction type N/A ACSN
JAK2 IFNGR2 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26192618 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217 interaction type N/A ACSN
JAK2 IFNG 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26192618 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217 interaction type N/A ACSN
JAK2 IL6R 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
JAK2 TYK2 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26192618 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545 interaction type N/A ACSN
JAK2 IL12RB1 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type N/A ACSN
JAK2 IL12RB2 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type N/A ACSN
JAK2 IL2RG 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 8041779 9834059 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
JAK2 IL4 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
JAK2 IL4R 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
JAK2 IL13 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
JAK2 IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
JAK2 CSF2 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 interaction type N/A ACSN
JAK2 CSF2RA 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 interaction type N/A ACSN
JAK2 CSF2RB 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 interaction type N/A ACSN
JAK2 IL6 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
JAK2 CSF3R 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 26192618 27216177 7512720 7521688 interaction type N/A ACSN
JAK2 STAT3 10918587 10925297 11294897 11350938 11445068 11867689 11940572 12244095 12576423 12626508 14551213 14610620 15284024 18988627 19833085 19834108 20237318 20406969 20581311 21071413 21840487 22754783 23180781 23331499 24091328 26192618 27216177 7512720 7521688 8626374 interaction type,stimulation,physical association anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink,SignaLink
OSM JAK2 16204061 21840487 26192618 interaction type N/A ACSN
SRC JAK2 11476890 12094222 16919435 17496910 17517963 25572304 26192618 26552706 27216177 interaction type N/A ACSN
JAK2 STAT1 10918587 11015446 11152457 11294897 11306493 11777960 11839738 11867689 12393492 12637327 12811837 12817007 14610620 14978237 14984365 15284024 15322115 18988627 19833085 19834108 20353823 20406969 20805416 21071413 21765015 22323450 22869907 23046136 23180781 23331499 24030977 24091328 26192618 27216177 7543024 7657660 7690989 interaction type,stimulation,physical association anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink,SignaLink
JAK2 IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
JAK2 STAT6 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 22992805 23046136 23331499 24030977 24091328 26192618 27216177 9852261 interaction type,phosphorylation reaction,stimulation N/A ACSN,SignaLink,SignaLink
JAK2 IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
JAK2 STAT4 10807786 11867689 12244147 12372421 14610620 15546391 16324152 19833085 20406969 21042762 21115385 22077060 23331499 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type,stimulation N/A ACSN,SignaLink
JAK2 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
SOCS1 JAK2 10064597 10485906 11713228 11971965 12193701 12223527 12811837 14522994 18988627 19287004 21071413 21469115 23124025 23180781 23331499 26192618 9202126 9344848 interaction type,stimulation,physical association pull down ACSN,InnateDB,SignaLink,SignaLink
PLCG2 JAK2 14978237 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGFR JAK2 15284024 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN6 JAK2 10772872 15983048 18988627 21071413 23180781 23331499 8943354 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink,SignaLink
JAK3 JAK2 12207328 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4R JAK2 12223527 23180781 8609418 physical association anti tag coimmunoprecipitation InnateDB
SOCS4 JAK2 17997974 23180781 physical association isothermal titration calorimetry InnateDB
TNFRSF1A JAK2 18606683 23180781 physical association anti tag coimmunoprecipitation InnateDB
JAK2 MAP3K5 19287004 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
DNAJA3 JAK2 11679576 23180781 physical association anti tag coimmunoprecipitation InnateDB
JAK2 CXCR4 10506573 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG JAK2 20098747 23180781 physical association protein array InnateDB
PLCG1 JAK2 17474147 23180781 physical association peptide array InnateDB
IL2RG JAK2 23180781 24608040 physical association anti tag coimmunoprecipitation InnateDB
IGF1R JAK2 23180781 25211187 physical association anti tag coimmunoprecipitation InnateDB
JAK2 PTPN11 21071413 23331499 8995399 stimulation N/A SignaLink,SignaLink
PTPN11 JAK2 14522994 18988627 21071413 23331499 7559603 8639815 8912646 8995399 interaction type N/A SignaLink,SignaLink
IRS1 JAK2 11208867 21071413 23331499 7782332 9492017 stimulation N/A SignaLink,SignaLink
IL6ST JAK2 23331499 8174677 stimulation N/A SignaLink,SignaLink
GHR JAK2 10502458 18988627 23331499 7540178 8063815 9211920 stimulation N/A SignaLink,SignaLink
IL12RB1 JAK2 10198225 23331499 stimulation N/A SignaLink,SignaLink
SOCS3 JAK2 10421843 10551777 10882725 18988627 21071413 23331499 9344848 stimulation N/A SignaLink,SignaLink
CRLF2 JAK2 10872831 18988627 23331499 stimulation N/A SignaLink,SignaLink
JAK2 STAT5B 11682625 12538627 18988627 21071413 23331499 9575217 stimulation N/A SignaLink,SignaLink
PRLR JAK2 10772872 11713228 18988627 20962278 21071413 23331499 stimulation N/A SignaLink,SignaLink
IL23R JAK2 12023369 18988627 23331499 stimulation N/A SignaLink,SignaLink
IFNGR1 JAK2 12040185 23331499 stimulation N/A SignaLink,SignaLink
IL3RA JAK2 15795318 23331499 stimulation N/A SignaLink,SignaLink
JAK2 STAT5A 11413148 15795318 18988627 21071413 23331499 7925280 8617237 9575217 stimulation N/A SignaLink,SignaLink
PTPN1 JAK2 11694501 15821101 18988627 23331499 stimulation N/A SignaLink,SignaLink
IFNGR2 JAK2 16381926 23331499 stimulation N/A SignaLink,SignaLink
IL31RA JAK2 18926762 23331499 stimulation N/A SignaLink,SignaLink
LEPR JAK2 12657512 21166956 23331499 8608603 phosphorylation reaction,stimulation N/A SignaLink,SignaLink
MPL JAK2 23331499 7543416 stimulation N/A SignaLink
IL13RA1 JAK2 23331499 8609418 stimulation N/A SignaLink
CSF2RA JAK2 23331499 9028317 stimulation N/A SignaLink
JAK2 STAM 23331499 9133424 stimulation N/A SignaLink
JAK2 DBP 23331499 9852261 stimulation N/A SignaLink
OSMR JAK2 10586060 23331499 stimulation N/A SignaLink
LIFR JAK2 11294841 23331499 stimulation N/A SignaLink
SH2B1 JAK2 11751854 23331499 9343427 stimulation N/A SignaLink
CSF3R JAK2 11812652 23331499 stimulation N/A SignaLink
IL5RA JAK2 15795318 23331499 9516124 stimulation N/A SignaLink
EPOR JAK2 11779507 18160720 23331499 8343951 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB10 JAK2 20005715 interaction type N/A PSP
GRB2 JAK2 20005715 interaction type N/A PSP
IRS1 JAK2 20005715 interaction type N/A PSP
IRS2 JAK2 20005715 interaction type N/A PSP,SignaLink
NCK1 JAK2 20005715 interaction type N/A PSP,SignaLink
NFKBIA JAK2 20005715 interaction type N/A PSP
PIK3R1 JAK2 20005715 interaction type N/A PSP
PKD1 JAK2 20005715 interaction type N/A PSP
PPP2R5A JAK2 20005715 interaction type N/A PSP
SH2B1 JAK2 20005715 interaction type N/A PSP
SH2B2 JAK2 20005715 interaction type N/A PSP
SHC1 JAK2 20005715 interaction type N/A PSP
SOCS1 JAK2 20005715 interaction type N/A PSP,SignaLink
SOCS3 JAK2 20005715 interaction type N/A PSP
STAM JAK2 20005715 interaction type N/A PSP
STAM JAK2 18988627 20005715 21071413 9133424 N/A N/A SignaLink
NFKBIA JAK2 20005715 N/A N/A SignaLink
GRB2 JAK2 20005715 21071413 7500025 N/A N/A SignaLink
GRB10 JAK2 18988627 20005715 20005715 9632636 N/A N/A SignaLink
SH2B1 JAK2 20005715 20005715 N/A N/A SignaLink
SH2B2 JAK2 10374881 10872802 18988627 20005715 20005715 21071413 N/A N/A SignaLink
SOCS3 JAK2 20005715 20005715 N/A N/A SignaLink
IRS1 JAK2 20005715 20005715 N/A N/A SignaLink
PIK3R1 JAK2 18988627 20005715 20005715 21071413 8702385 8702385 N/A N/A SignaLink
SHC1 JAK2 18988627 20005715 20005715 7535773 9126968 N/A N/A SignaLink
PKD1 JAK2 12007403 18988627 20005715 20005715 N/A N/A SignaLink
PPP2R5A JAK2 18988627 20005715 20005715 8702385 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 JAK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 JAK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 JAK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 JAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 JAK2 11163768 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 JAK2 19876927 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 JAK2 21239533 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 JAK2 17151100 19783654 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 JAK2 N/A 15806104 20548334 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00000ED600 JAK2 15806104 20548334 24718681 25055044 25416803 28006751 28186962 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 JAK2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000040EE1D JAK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000076B539 JAK2 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001F0C23 JAK2 25416803 26011312 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000013ABA3 JAK2 25416803 26149212 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 JAK2 25416803 27323056 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
JAK2 H3C1 22135298 phosphorylation N/A PhosphoSite
JAK2 GRB2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
JAK2 PAK1 22135298 phosphorylation N/A PhosphoSite
JAK2 PRMT5 22135298 phosphorylation N/A PhosphoSite
JAK2 STAP2 22135298 phosphorylation N/A PhosphoSite
JAK2 JAK2 22135298 phosphorylation N/A PhosphoSite
JAK2 EZH2 22135298 phosphorylation N/A PhosphoSite
JAK2 STAT5A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
JAK2 CCR2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
JAK2 MAPK1 22135298 phosphorylation N/A PhosphoSite
JAK2 SOCS3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
JAK2 STAT3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
JAK2 PDK1 22135298 phosphorylation N/A PhosphoSite
JAK2 MAPK3 22135298 phosphorylation N/A PhosphoSite
JAK2 GAB2 22135298 phosphorylation N/A PhosphoSite
JAK2 MAP3K5 22135298 phosphorylation N/A PhosphoSite
JAK2 STAT1 22135298 phosphorylation N/A PhosphoSite
JAK2 ARHGEF1 22135298 phosphorylation N/A PhosphoSite
IL12RB2 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL12RB2 25361965 interaction type N/A PTMCode2
OSMR JAK2 25361965 interaction type N/A PTMCode2
JAK2 OSMR 25361965 interaction type N/A PTMCode2
TEC JAK2 25361965 interaction type N/A PTMCode2
JAK2 TEC 25361965 interaction type N/A PTMCode2
IRS2 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IRS2 25361965 interaction type N/A PTMCode2
CCR2 JAK2 25361965 interaction type N/A PTMCode2
STAT3 JAK2 25361965 interaction type N/A PTMCode2
SIRPA JAK2 25361965 interaction type N/A PTMCode2
JAK2 SIRPA 25361965 interaction type N/A PTMCode2
STAM JAK2 25361965 interaction type N/A PTMCode2
JAK2 STAM 25361965 interaction type N/A PTMCode2
PTPRC JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPRC 25361965 interaction type N/A PTMCode2
RAF1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 RAF1 25361965 interaction type N/A PTMCode2
PTK2B JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTK2B 25361965 interaction type N/A PTMCode2
IL4R JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL4R 25361965 interaction type N/A PTMCode2
HSPA8 JAK2 25361965 interaction type N/A PTMCode2
JAK2 HSPA8 25361965 interaction type N/A PTMCode2
GHR JAK2 25361965 interaction type N/A PTMCode2
JAK2 GHR 25361965 interaction type N/A PTMCode2
LEPR JAK2 25361965 interaction type N/A PTMCode2
JAK2 LEPR 25361965 interaction type N/A PTMCode2
GTF2I JAK2 25361965 interaction type N/A PTMCode2
JAK2 GTF2I 25361965 interaction type N/A PTMCode2
JAKMIP3 JAK2 25361965 interaction type N/A PTMCode2
JAK2 JAKMIP3 25361965 interaction type N/A PTMCode2
IL6ST JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL6ST 25361965 interaction type N/A PTMCode2
IL10RA JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL10RA 25361965 interaction type N/A PTMCode2
CSF3R JAK2 25361965 interaction type N/A PTMCode2
JAK2 CSF3R 25361965 interaction type N/A PTMCode2
STAM2 JAK2 25361965 interaction type N/A PTMCode2
JAK2 STAM2 25361965 interaction type N/A PTMCode2
AGTR1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 AGTR1 25361965 interaction type N/A PTMCode2
FYN JAK2 25361965 interaction type N/A PTMCode2
JAK2 FYN 25361965 interaction type N/A PTMCode2
SH2B1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 SH2B1 25361965 interaction type N/A PTMCode2
STAT5A JAK2 25361965 interaction type N/A PTMCode2
HTR2A JAK2 25361965 interaction type N/A PTMCode2
JAK2 HTR2A 25361965 interaction type N/A PTMCode2
DNAJA3 JAK2 25361965 interaction type N/A PTMCode2
JAK2 DNAJA3 25361965 interaction type N/A PTMCode2
EPOR JAK2 25361965 interaction type N/A PTMCode2
JAK2 EPOR 25361965 interaction type N/A PTMCode2
CSF1R JAK2 25361965 interaction type N/A PTMCode2
JAK2 CSF1R 25361965 interaction type N/A PTMCode2
PTPN12 JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPN12 25361965 interaction type N/A PTMCode2
EGFR JAK2 25361965 interaction type N/A PTMCode2
JAK2 EGFR 25361965 interaction type N/A PTMCode2
ABL1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 ABL1 25361965 interaction type N/A PTMCode2
IRS1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IRS1 25361965 interaction type N/A PTMCode2
PLAUR JAK2 25361965 interaction type N/A PTMCode2
JAK2 PLAUR 25361965 interaction type N/A PTMCode2
KIT JAK2 25361965 interaction type N/A PTMCode2
JAK2 KIT 25361965 interaction type N/A PTMCode2
GRB2 JAK2 25361965 interaction type N/A PTMCode2
UBASH3B JAK2 25361965 interaction type N/A PTMCode2
JAK2 UBASH3B 25361965 interaction type N/A PTMCode2
IFNGR1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IFNGR1 25361965 interaction type N/A PTMCode2
IL3RA JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL3RA 25361965 interaction type N/A PTMCode2
MPL JAK2 25361965 interaction type N/A PTMCode2
JAK2 MPL 25361965 interaction type N/A PTMCode2
ERBB3 JAK2 25361965 interaction type N/A PTMCode2
JAK2 ERBB3 25361965 interaction type N/A PTMCode2
ERBB2 JAK2 25361965 interaction type N/A PTMCode2
JAK2 ERBB2 25361965 interaction type N/A PTMCode2
PIK3R1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 PIK3R1 25361965 interaction type N/A PTMCode2
TSHR JAK2 25361965 interaction type N/A PTMCode2
JAK2 TSHR 25361965 interaction type N/A PTMCode2
JAK2 PRLR 25361965 interaction type N/A PTMCode2
PRLR JAK2 25361965 interaction type N/A PTMCode2
JAK2 ALK 25361965 interaction type N/A PTMCode2
ALK JAK2 25361965 interaction type N/A PTMCode2
JAK2 GRB10 25361965 interaction type N/A PTMCode2
GRB10 JAK2 25361965 interaction type N/A PTMCode2
JAK2 CSF2RB 25361965 interaction type N/A PTMCode2
CSF2RB JAK2 25361965 interaction type N/A PTMCode2
JAK2 CXCR4 25361965 interaction type N/A PTMCode2
CXCR4 JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 JAK2 25361965 interaction type N/A PTMCode2
JAK2 SHC1 25361965 interaction type N/A PTMCode2
SHC1 JAK2 25361965 interaction type N/A PTMCode2
SOCS3 JAK2 25361965 interaction type N/A PTMCode2
TNFRSF1A JAK2 25361965 interaction type N/A PTMCode2
JAK2 TNFRSF1A 25361965 interaction type N/A PTMCode2
PTPN1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPN1 25361965 interaction type N/A PTMCode2
INSR JAK2 25361965 interaction type N/A PTMCode2
JAK2 INSR 25361965 interaction type N/A PTMCode2
IL2RB JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL2RB 25361965 interaction type N/A PTMCode2
IL23R JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL23R 25361965 interaction type N/A PTMCode2
BCR JAK2 25361965 interaction type N/A PTMCode2
JAK2 BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 JAK2 10421843 14525934 24234451 25348397 9344848 association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
YES1 JAK2 14525934 25348397 8702385 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HSPA8 JAK2 11679576 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBASH3B JAK2 12370296 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PPP1CC JAK2 25348397 N/A two hybrid,physical interaction ComPPI
AGTR1 JAK2 25348397 N/A physical interaction,in vivo ComPPI
STAT1 JAK2 10918587 11152457 11294897 11839738 12637327 12817007 14525934 15322115 24234451 24255956 25348397 7543024 7657660 7690989 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B JAK2 21423214 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EMD JAK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 JAK2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TYK2 JAK2 24234451 25348397 26175413 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CALM1 JAK2 25348397 N/A physical interaction ComPPI
PTPN6 JAK2 14525934 25348397 8943354 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSP90AB1 JAK2 25348397 N/A physical interaction ComPPI
ERBB2 JAK2 11940572 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VAV1 JAK2 14525934 25348397 7530656 9162069 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRLR JAK2 10772872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TEC JAK2 14525934 25348397 9473212 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL6ST JAK2 25348397 N/A physical interaction ComPPI
PTK2B JAK2 11818507 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EZH2 JAK2 25348397 N/A physical interaction ComPPI
SOCS1 JAK2 10064597 10421843 11971965 14525934 24234451 25348397 9202126 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MST1R JAK2 14525934 14982882 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KIT JAK2 14525934 25348397 7527392 8611693 9355737 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LYN JAK2 14525934 25348397 9573010 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3R1 JAK2 14525934 17474147 24234451 25348397 8702385 physical association experimental interaction detection,peptide array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 JAK2 14525934 25348397 7559603 8912646 8995399 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SRC JAK2 21075308 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GRB10 JAK2 14525934 25348397 9632636 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SH2B2 JAK2 10872802 14525934 15767667 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
PLCG2 JAK2 25348397 N/A in vivo ComPPI
SHC1 JAK2 14525934 25348397 7535773 9126968 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NCK1 JAK2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
OSMR JAK2 10586060 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRB2 JAK2 14525934 17474147 24234451 25348397 7500025 physical association experimental interaction detection,peptide array,physical interaction,in vivo ComPPI,HPRD,IntAct
GTF2I JAK2 11313464 11373296 11934902 14525934 25348397 9012831 9837922 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KPNB1 JAK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDGFRB JAK2 14525934 25348397 8657151 9484840 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FES JAK2 14525934 25348397 8631962 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRS2 JAK2 12960006 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GHR JAK2 10502458 14525934 25348397 7540178 8063815 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSP90AA1 JAK2 25348397 N/A physical interaction ComPPI
TUB JAK2 10455176 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
STAT2 JAK2 14525934 25348397 7746328 N/A experimental interaction detection,in vivo ComPPI,HPRD
IFNGR1 JAK2 11438544 14525934 25348397 7499845 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PKD1 JAK2 12007403 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IFNGR2 JAK2 14525934 25348397 7514165 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK1 JAK2 24234451 25348397 26175413 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
PTAFR JAK2 25348397 N/A physical interaction ComPPI
PTPN1 JAK2 11694501 11970898 14525934 15821101 21806020 24234451 25348397 dephosphorylation reaction,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PPP2R5A JAK2 14525934 25348397 8702385 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP3K5 JAK2 25348397 N/A physical interaction ComPPI
LEPR JAK2 11585385 14525934 24234451 25348397 8608603 association coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
TNFRSF1A JAK2 14525934 25348397 9510175 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
STAT5A JAK2 11413148 14525934 25348397 7925280 8617237 9575217 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STAT5B JAK2 12538627 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIRPA JAK2 10842184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DNAJA3 JAK2 11679576 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
NFKBIA JAK2 11493922 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRMT5 JAK2 10531356 14525934 21316606 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
STAM2 JAK2 10899310 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HNRNPL JAK2 25348397 N/A physical interaction ComPPI
PTPN12 JAK2 11731619 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MDK JAK2 14525934 25348397 9452495 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP2CA JAK2 11440634 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PKM JAK2 25348397 N/A protein kinase assay ComPPI
ASB2 JAK2 25348397 N/A physical interaction ComPPI
CCR5 JAK2 11591716 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HTR2A JAK2 14525934 25348397 9169451 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
H3-4 JAK2 25348397 N/A physical interaction ComPPI
EGFR JAK2 10635327 14525934 16273093 24234451 25348397 9363897 N/A experimental interaction detection,protein array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
EPOR JAK2 11779507 12441334 14525934 25348397 8343951 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FGFR1 JAK2 25348397 N/A physical interaction ComPPI
CSF3R JAK2 14525934 25348397 7775438 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BCR JAK2 12023981 12370803 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JAK3 JAK2 11585385 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL2RB JAK2 25348397 N/A physical interaction ComPPI
VHL JAK2 25348397 N/A physical interaction ComPPI
IRS1 JAK2 12960006 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 BRCA1 11163768 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
JAK2 STAT3 10918587 10925297 11294897 11350938 11940572 12244095 12576423 12626508 14525934 14551213 25348397 8626374 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JAK2 CRLF2 10872831 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
JAK2 HES1 14525934 15156153 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JAK2 INSR 12456798 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 IL4R 14525934 25348397 8609418 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 MPL 10224114 10918061 10979953 14525934 24234451 24931576 25348397 7534285 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,in vitro,in vivo,confocal microscopy,proximity ligation assay ComPPI,HPRD,IntAct
JAK2 IL3RA 14525934 15988755 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
JAK2 PPIA 12668872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 CTLA4 10842319 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 FYN 10551884 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 CSF2RB 10772872 14525934 16437163 18692472 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
JAK2 PTPRC 25348397 N/A in vitro ComPPI
JAK2 CXCR4 10506573 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
JAK2 RAF1 10205168 11134016 14525934 25348397 8876196 9689060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JAK2 CCR2 25348397 N/A in vitro,in vivo ComPPI
JAK2 IL12RB2 10198225 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 STAM 14525934 25348397 9133424 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 PPP2R1B 11440634 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 TSHR 10809230 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 STAP2 12540842 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
JAK2 ELP2 10954736 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAK2 IL23R 12023369 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JAK2 SH2B1 10757801 12551917 14525934 15767667 17565041 24234451 25348397 9343427 association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
JAK2 PTK2 25348397 N/A physical interaction ComPPI
JAK2 IL5RA 14525934 24234451 25348397 9516124 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
JAK2 ALK 25348397 N/A physical interaction ComPPI
JAK2 IKBKG 25348397 N/A physical interaction ComPPI
JAK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
JAK2 SKP2 25348397 N/A physical interaction ComPPI
JAK2 H3C15 25348397 N/A physical interaction ComPPI
JAK2 IL2RG 25348397 N/A physical interaction ComPPI
JAK2 ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
JAK2 PLCG1 17474147 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
JAK2 RBMX 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
JAK2 DTX3L 25348397 N/A physical interaction ComPPI
JAK2 NAP1L1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JAK2 RCN1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JAK2 SLC2A1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JAK2 UBP1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JAK2 ARL11 25348397 N/A physical interaction ComPPI
JAK2 HSFY1 25348397 N/A physical interaction ComPPI
JAK2 HDAC6 25348397 N/A physical interaction ComPPI
JAK2 G3BP1 15743820 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
JAK2 PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
ASS1 JAK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IGF1R JAK2 10747872 14525934 25348397 9492017 N/A experimental interaction detection,in vitro ComPPI,HPRD
JAK2 HES5 14525934 15156153 N/A experimental interaction detection HPRD
JAK2 JAK2 11593427 11818507 14525934 15121872 15143187 15143188 17027227 21841788 22820988 24234451 7889566 9111318 9516124 phosphorylation reaction experimental interaction detection,protein kinase assay HPRD,IntAct
ABL1 JAK2 11593427 14525934 15143187 9111318 N/A experimental interaction detection HPRD
VCP JAK2 11087817 14525934 N/A experimental interaction detection HPRD
JAK2 CAV1 12388746 27898060 N/A N/A OmniPath
JAK2 PLCG1 17474147 27898060 stimulant N/A OmniPath
PTPN1 JAK2 11694501 11970898 15780598 158211 15821101 21806020 27898060 inhibition,stimulant N/A OmniPath
JAK2 EPOR 10579919 11779507 12441334 12524467 14982882 18672044 27898060 8343951 stimulant N/A OmniPath
EPOR JAK2 11779507 12441334 14982882 18160720 27898060 8343951 stimulant N/A OmniPath
JAK2 PLCG2 14978237 27898060 N/A N/A OmniPath
JAK2 EGFR 10358079 10635327 15284024 16273093 16799092 17016520 17389395 18669648 18691976 27898060 9038232 9363897 N/A N/A OmniPath
IL3RA JAK2 15795318 15988755 17312100 27898060 stimulant N/A OmniPath
CXCR4 JAK2 10506573 27898060 stimulant N/A OmniPath
SOCS3 JAK2 10421843 10551777 10882725 11314018 15143188 15514089 19543316 22342841 23454976 24354892 27898060 9344848 inhibition,stimulant N/A OmniPath
JAK2 CSF2RA 27898060 8977526 stimulant N/A OmniPath
CSF2RA JAK2 27898060 8977526 9028317 stimulant N/A OmniPath
JAK2 IFNGR1 11438544 15864272 17063185 21689637 23898330 27898060 7499845 7673114 stimulant N/A OmniPath
IFNGR1 JAK2 11438544 12040185 15864272 17063185 21689637 23898330 27898060 7499845 7673114 stimulant N/A OmniPath
JAK2 STAT6 18852293 27898060 9852261 stimulant N/A OmniPath
CSF3R JAK2 11812652 27898060 7775438 stimulant N/A OmniPath
JAK3 JAK2 11585385 12207328 27898060 N/A N/A OmniPath
SOCS1 JAK2 10064597 10421843 10455112 11314018 11713228 11971965 14522994 18508766 19287004 27898060 9202126 9344848 inhibition,stimulant N/A OmniPath
JAK2 SOCS1 10064597 10421843 10455112 11314018 11713228 11971965 14522994 18508766 19287004 27898060 9202126 9344848 N/A N/A OmniPath
KIT JAK2 15526160 27898060 7527392 8611693 9355737 stimulant N/A OmniPath
IL6ST JAK2 27898060 8174677 9716487 stimulant N/A OmniPath
JAK2 STAT5A 11413148 11641791 12529425 15795318 16497976 17016520 17081983 17389395 18083107 18250158 19088846 19534553 27898060 7925280 8617237 9047382 9575217 stimulant N/A OmniPath
IL5RA JAK2 15795318 17312100 27898060 7602114 9516124 stimulant N/A OmniPath
IRS1 JAK2 11208867 12960006 27898060 7782332 9492017 stimulant N/A OmniPath
JAK2 H3C1 19783980 21156283 26175159 27898060 stimulant N/A OmniPath
JAK2 MAP3K5 19287004 27898060 inhibition N/A OmniPath
IKBKG JAK2 20098747 27898060 N/A N/A OmniPath
JAK2 PTPN6 10772872 15983048 27898060 8943354 stimulant N/A OmniPath
PTPN6 JAK2 10772872 15983048 27898060 8943354 inhibition,stimulant N/A OmniPath
JAK2 STAT1 10748192 10918587 11152457 11294897 11438544 11839738 12637327 12817007 14978237 14984365 15284024 15322115 19834108 20353823 24255956 27898060 7504784 7504785 7543024 7592750 7615558 7657660 7690989 stimulant N/A OmniPath
STAT1 JAK2 10918587 11152457 11294897 11839738 12637327 12817007 14978237 14984365 15284024 15322115 19834108 20353823 24255956 27898060 7543024 7657660 7690989 N/A N/A OmniPath
IL10RA JAK2 26260587 27898060 stimulant N/A OmniPath
LEPR JAK2 12657512 17312100 27898060 8608603 stimulant N/A OmniPath
MAPK3 JAK2 16705159 27898060 inhibition N/A OmniPath
JAK2 JAK1 27898060 7504784 stimulant N/A OmniPath
JAK1 JAK2 27898060 7504784 stimulant N/A OmniPath
JAK2 GTF2I 11313464 11373296 11934902 27898060 9012831 9837922 stimulant N/A OmniPath
JAK2 EZH2 24469040 27898060 inhibition N/A OmniPath
JAK2 PRMT5 10531356 21316606 27898060 inhibition N/A OmniPath
ABL1 JAK2 11593427 15143187 20841568 27898060 9111318 stimulant N/A OmniPath
JAK2 ITGB2 25624455 27898060 stimulant N/A OmniPath
JAK2 RAF1 10205168 11134016 27898060 8876196 9689060 stimulant N/A OmniPath
JAK2 GHR 10502458 21347402 24280222 27898060 7540178 8063815 8647880 9121492 stimulant N/A OmniPath
GHR JAK2 10502458 17312100 21347402 24280222 27898060 7540178 8063815 9211920 stimulant N/A OmniPath
JAK2 PAK1 17726028 21566085 21719533 23340249 25125660 25466889 27898060 N/A N/A OmniPath
JAK2 PTPN11 14522994 27898060 7559603 8639815 8912646 8995399 stimulant N/A OmniPath
PTPN11 JAK2 14522994 27898060 7559603 8639815 8912646 8995399 inhibition N/A OmniPath
TNFRSF1A JAK2 18606683 27898060 9510175 N/A N/A OmniPath
PRLR JAK2 10772872 11713228 17312100 20962278 27898060 9202403 stimulant N/A OmniPath
JAK2 STAT3 10918587 10925297 11294897 11350938 11445068 11940572 12244095 12576423 12595539 12626508 14551213 15143188 15156153 15284024 16497976 17016520 17389395 19834108 19901323 21102457 22402124 26260587 27898060 8626374 9211920 9582023 stimulant N/A OmniPath
STAT3 JAK2 10918587 10925297 11294897 11350938 11445068 11940572 12244095 12576423 12626508 14551213 15143188 15156153 15284024 19834108 21102457 22402124 27898060 8626374 9211920 N/A N/A OmniPath
JAK2 IL4R 12223527 27898060 8609418 N/A N/A OmniPath
IL4R JAK2 12223527 18852293 27898060 8609418 stimulant N/A OmniPath
JAK2 STAT5B 11682625 12538627 24354892 27898060 9047382 9575217 stimulant N/A OmniPath
JAK2 STAT4 16324152 27898060 inhibition,stimulant N/A OmniPath
IL12RB1 JAK2 10198225 27898060 stimulant N/A OmniPath
JAK2 SIRPA 10842184 17016520 17389395 27898060 N/A N/A OmniPath
IL2RG JAK2 24608040 27898060 8041779 stimulant N/A OmniPath
MPL JAK2 10224114 10918061 10979953 24931576 27898060 7534285 7543416 stimulant N/A OmniPath
JAK2 CTLA4 10842319 27898060 inhibition,stimulant N/A OmniPath
JAK2 CCR2 27898060 9670957 stimulant N/A OmniPath
DAB2IP JAK2 27858941 27898060 inhibition N/A OmniPath
SH2B1 JAK2 10757801 11751854 12370803 12551917 15767667 17565041 27898060 9343427 inhibition,stimulant N/A OmniPath
JAK2 IFNGR2 23898330 27898060 7514165 7901766 stimulant N/A OmniPath
IFNGR2 JAK2 16381926 23898330 27898060 7514165 7901766 stimulant N/A OmniPath
IL23R JAK2 12023369 27898060 stimulant N/A OmniPath
JAK2 STAP2 12540842 27898060 N/A N/A OmniPath
JAK2 APOA1 14668333 27898060 stimulant N/A OmniPath
JAK2 DNAJA3 11679576 27898060 N/A N/A OmniPath
IL13RA1 JAK2 27898060 8609418 stimulant N/A OmniPath
CRLF2 JAK2 10872831 27898060 stimulant N/A OmniPath
JAK2 STAM 27898060 9133424 stimulant N/A OmniPath
JAK2 GAB2 15170389 18644434 23980151 27898060 stimulant N/A OmniPath
PTPRC JAK2 11201744 27898060 N/A N/A OmniPath
SOCS4 JAK2 17997974 27898060 inhibition N/A OmniPath
SH3KBP1 JAK2 27898060 8943354 stimulant N/A OmniPath
JAK2 ARHGEF1 20098430 27898060 stimulant N/A OmniPath
IL31RA JAK2 18926762 27898060 stimulant N/A OmniPath
PTPN12 JAK2 11731619 27898060 inhibition N/A OmniPath
JAK2 DAB1 12077184 15316068 27898060 N/A N/A OmniPath
NIN JAK2 25332239 27898060 inhibition N/A OmniPath
JAK2 ITGAL 25624455 27898060 stimulant N/A OmniPath
PTPRG JAK2 25624455 27898060 inhibition N/A OmniPath
JAK2 PYGB 27898060 9362479 N/A N/A OmniPath

Visualization










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