GENE：IL1B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IL1B |
| FullNmae | interleukin 1 beta |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5992 |
| EnsembleID | ENSG00000125538 |
| Uniprot | P01584 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IL1B | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1B | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| IL1B | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1B | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| IL1B | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1B | immunogenic | 37275552 | To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. | retulator signature |
| IL1B | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL1B | apoptosis | 38991640 | Both lnc-HZ06 and IL1B suppress trophoblast cell migration/invasion and increase apoptosis. | retulator signature |
| IL1B | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IL1B | GO:0001660,GO:0001934,GO:0001934,GO:0002711,GO:0005125,GO:0005125,GO:0005125,GO:0005125,GO:0005149,GO:0005178,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005764,GO:0005829,GO:0006915,GO:0006954,GO:0006954,GO:0006954,GO:0006954,GO:0006955,GO:0007165,GO:0007249,GO:0007254,GO:0007267,GO:0007566,GO:0008284,GO:0008285,GO:0009743,GO:0010573,GO:0010575,GO:0010575,GO:0010628,GO:0010628,GO:0010628,GO:0010718,GO:0010829,GO:0014805,GO:0019221,GO:0019221,GO:0019904,GO:0030141,GO:0030213,GO:0030335,GO:0030593,GO:0030730,GO:0030949,GO:0031394,GO:0031622,GO:0032308,GO:0032496,GO:0032725,GO:0032729,GO:0032743,GO:0032755,GO:0032755,GO:0032757,GO:0033092,GO:0033198,GO:0034116,GO:0034116,GO:0035234,GO:0035505,GO:0042102,GO:0043122,GO:0043123,GO:0043406,GO:0043407,GO:0045429,GO:0045766,GO:0045766,GO:0045833,GO:0045840,GO:0045893,GO:0045917,GO:0045944,GO:0046330,GO:0046627,GO:0046827,GO:0048143,GO:0050691,GO:0050729,GO:0050766,GO:0050767,GO:0050768,GO:0050796,GO:0050805,GO:0050830,GO:0050995,GO:0050996,GO:0050999,GO:0050999,GO:0051044,GO:0051091,GO:0051092,GO:0051781,GO:0060252,GO:0060355,GO:0060559,GO:0070164,GO:0070372,GO:0070487,GO:0070498,GO:0070555,GO:0071222,GO:0071260,GO:0071310,GO:0071466,GO:0071639,GO:0097192,GO:0097398,GO:0150078,GO:1900745,GO:1901224,GO:1902680,GO:1903140,GO:1903597,GO:2000556,GO:2001240 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IL1B | hsa:3553 | path:hsa01523 | Antifolate resistance - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05133 | Pertussis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05134 | Legionellosis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05144 | Malaria - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05162 | Measles - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05321 | Inflammatory bowel disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
| IL1B | hsa:3553 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KLRG1 | IL1B | 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 | interaction type | N/A | ACSN |
| PTPN11 | IL1B | 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 | interaction type | N/A | ACSN |
| NLRP3 | IL1B | 19104081 20385749 23202296 26192618 26885855 27048821 27066895 27439607 27984721 | interaction type | N/A | ACSN |
| PYCARD | IL1B | 19104081 20385749 23180781 23202296 24803432 26192618 26885855 27048821 27066895 27439607 27984721 | interaction type,physical association | fluorescence microscopy | ACSN,InnateDB |
| BCL3 | IL1B | 12907458 14668329 15465827 15749884 16713974 17404308 20547845 26192618 | interaction type | N/A | ACSN |
| STAT3 | IL1B | 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17386941 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23180781 23390297 23454751 23953057 24857661 26192618 27216177 28186502 7543512 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| NLRP10 | IL1B | 15096476 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL1B | NLRP7 | 15817483 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL1B | CASP1 | 23180781 9121587 | cleavage reaction | protease assay | InnateDB |
| IL1R1 | IL1B | 23180781 8142597 | physical association | chromatography technology | InnateDB |
| SPI1 | IL1B | 16439360 17283046 17386941 23180781 7799967 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| IL1B | CEBPB | 16439360 17283046 17386941 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RELA | IL1B | 15972680 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFKB1 | IL1B | 15972680 23180781 8021507 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| IL1B | JUN | 17283046 18566416 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL1B | TBP | 18566416 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SSRP1 | IL1B | 18566416 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IRF4 | IL1B | 12676954 18566416 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IRF8 | IL1B | 17386941 18566416 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL1R2 | IL1B | 1833184 20802483 23180781 7878046 | physical association | protein cross-linking with a bifunctional reagent,x-ray crystallography,competition binding | InnateDB |
| IL1B | ALPP | 23180781 9099704 | physical association | affinity chromatography technology | InnateDB |
| UMOD | IL1B | 23180781 9099704 | physical association | affinity chromatography technology | InnateDB |
| IL1B | STAT1 | 17386941 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| REL | IL1B | 19122653 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RELB | IL1B | 19122653 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NCOR1 | IL1B | 19864602 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HMGB1 | IL1B | 18250463 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL1RAP | IL1B | 20802483 23180781 | physical association | surface plasmon resonance | InnateDB |
| CASP1 | IL1B | 19439663 23180781 | protein cleavage | protease assay | InnateDB |
| IL1B | IL1R1 | 23331499 9062193 | stimulation | N/A | SignaLink,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | IL1B | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| NFIL3 | IL1B | 8547328 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| RELA | IL1B | 10080875 10963848 12686724 14960579 15972680 16433741 17707233 18285351 20336759 8021507 8413223 8679226 9058643 9878621 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | IL1B | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | IL1B | 17707233 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | IL1B | 10801783 17386941 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | IL1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AHR | IL1B | 23349129 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | IL1B | 10383163 10801783 17386941 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HMGA1 | IL1B | 15901130 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HSF1 | IL1B | 10328874 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| IRF8 | IL1B | 17386941 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | IL1B | 11306276 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUNB | IL1B | 11306276 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KLF4 | IL1B | 22449968 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | IL1B | 10080875 10963848 12686724 14960579 16433741 17707233 18285351 20336759 8413223 8679226 9058643 9878621 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKBIA | IL1B | 15228586 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| REL | IL1B | 8413223 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SIRT1 | IL1B | 21245135 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | IL1B | 17386941 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SUGP1 | IL1B | 9878621 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| YY1 | IL1B | 22467534 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF1 | IL1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPD | IL1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | IL1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | IL1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | IL1B | 21131358 | rna interference,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000029D9F1 | IL1B | 21282569 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | IL1B | 21131358 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00002A8BC6 | IL1B | 25416803 27542871 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000039E1E1 | IL1B | 25416803 25950430 | mrna cleavage,inhibition | quantitative reverse transcription pcr | TarBase |
| URS0000070B1D | IL1B | 25416803 27542871 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IL1R1 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | IL1RL2 | 25361965 | interaction type | N/A | PTMCode2 |
| IL1RL2 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | ADRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| ADRB2 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | WDR48 | 25361965 | interaction type | N/A | PTMCode2 |
| WDR48 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | UBE2N | 25361965 | interaction type | N/A | PTMCode2 |
| UBE2N | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | A2M | 25361965 | interaction type | N/A | PTMCode2 |
| A2M | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | MAPK8IP2 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP2 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | IL1R2 | 25361965 | interaction type | N/A | PTMCode2 |
| IL1R2 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | CASP4 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP4 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | CARD16 | 25361965 | interaction type | N/A | PTMCode2 |
| CARD16 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| MMP2 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | MMP2 | 25361965 | interaction type | N/A | PTMCode2 |
| IL1RAP | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
| IL1B | IL1RAP | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ZC3H12A | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| SP1 | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| LYN | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| CMA1 | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| IL1RAP | IL1B | 14525934 16306937 20802483 22426547 24234451 25348397 9820540 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| CASP1 | IL1B | 14525934 1919001 19439663 24234451 25348397 7797510 | protein cleavage | experimental interaction detection,physical interaction,biochemical,protease assay,in vitro,in vivo,protein cleavage | ComPPI,HPRD,IntAct |
| PTPN1 | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| MYC | IL1B | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| HMGB1 | IL1B | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| PRTN3 | IL1B | 10339575 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PKM | IL1B | 25348397 | N/A | protein kinase assay | ComPPI |
| ADRB2 | IL1B | 11238007 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| FYN | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| CASP4 | IL1B | 14525934 1919001 25348397 7797510 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ELAVL1 | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| MMP2 | IL1B | 14525934 25348397 27898060 8663297 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| EGR1 | IL1B | 25348397 | N/A | physical interaction | ComPPI |
| A2M | IL1B | 14525934 24234451 2466831 25241761 25348397 27898060 9714181 | physical association | experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct,OmniPath |
| IL1B | IL1R1 | 14525934 24234451 25348397 9062193 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| IL1B | IL1R2 | 14525934 25348397 7878046 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| IL1B | APP | 25348397 | N/A | physical interaction | ComPPI |
| IL1B | IKBKG | 23104095 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| IL1B | STING1 | 24234451 25348397 29251827 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| IL1B | IL1B | 14525934 2946959 | N/A | experimental interaction detection | HPRD |
| CASP1 | IL1B | 17039247 1919001 19439663 27898060 7797510 8999548 9121587 | inhibition,stimulant | N/A | OmniPath |
| CASP5 | IL1B | 17039247 27898060 | stimulant | N/A | OmniPath |
| IL1B | IL1R2 | 1833184 20802483 27898060 7878046 8332913 | inhibition | N/A | OmniPath |
| GZMA | IL1B | 19254476 27898060 | stimulant | N/A | OmniPath |
| IL1B | IL1R1 | 17145710 24166242 27898060 8142597 9062193 9625767 | stimulant | N/A | OmniPath |
| IL1B | HMGB1 | 18250463 27898060 | N/A | N/A | OmniPath |
| IL1B | UMOD | 27898060 9099704 | N/A | N/A | OmniPath |
| IL1B | IL1RAP | 20802483 27898060 9820540 | stimulant | N/A | OmniPath |
| IL1RAP | IL1B | 20802483 27898060 9820540 | inhibition | N/A | OmniPath |
| IL1B | ALPP | 27898060 9099704 | inhibition | N/A | OmniPath |
| NLRP10 | IL1B | 15096476 27898060 | N/A | N/A | OmniPath |
| IL1B | TRIM16L | 16575408 27898060 | N/A | N/A | OmniPath |