GENE：TRPM7
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TRPM7 |
| FullNmae | transient receptor potential cation channel subfamily M member 7 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17994 |
| EnsembleID | ENSG00000092439 |
| Uniprot | Q96QT4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TRPM7 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TRPM7 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TRPM7 | GO:0001726,GO:0003779,GO:0004674,GO:0005262,GO:0005262,GO:0005524,GO:0005886,GO:0006816,GO:0016310,GO:0016340,GO:0017022,GO:0031032,GO:0046872,GO:0051262,GO:0070266,GO:0070588,GO:0098655,GO:0106310 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TRPM7 | hsa:54822 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| TRPM7 | hsa:54822 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| TRPM7 | hsa:54822 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| TRPM7 | hsa:54822 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | TRPM7 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | TRPM7 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TRPM7 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | TRPM7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | TRPM7 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000016D2D4 | TRPM7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D4175 | TRPM7 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | TRPM7 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052E1A6 | TRPM7 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000475586 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000521626 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008B558 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000183BED | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC864 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FC26E | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411752 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070CD2 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C0099 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027352D | TRPM7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003003B4 | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001481F9 | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043F369 | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FB065 | TRPM7 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TRPM7 | MYH9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| TRPM7 | ANXA1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| TRPM7 | EEF2K | 22135298 | phosphorylation | N/A | PhosphoSite |
| ANXA1 | TRPM7 | 25361965 | interaction type | N/A | PTMCode2 |
| EEF2 | TRPM7 | 25361965 | interaction type | N/A | PTMCode2 |
| TRPM7 | EEF2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SNAP29 | TRPM7 | 25348397 | N/A | physical interaction | ComPPI |
| VAPA | TRPM7 | 25348397 | N/A | physical interaction | ComPPI |
| RAB7A | TRPM7 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | H3-4 | 14525934 14594813 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| TRPM7 | PLCB2 | 11941371 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| TRPM7 | TRPM6 | 14525934 14976260 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| TRPM7 | PLCB1 | 11941371 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| TRPM7 | EEF2 | 14525934 14594813 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TRPM7 | MBP | 14525934 14594813 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| TRPM7 | PLCG1 | 11941371 14525934 25348397 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| TRPM7 | PLCB3 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | ZACN | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | TCTN3 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| TRPM7 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | ARL15 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | TEX28 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | PNLDC1 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| TRPM7 | MYH9 | 18675813 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| TRPM7 | MYH10 | 18675813 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| TRPM7 | MYH14 | 18675813 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| TRPM7 | CANX | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| TRPM7 | LAMP1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| TRPM7 | TRPM7 | 14525934 14594813 | N/A | experimental interaction detection | HPRD |
| TRPM7 | ANXA1 | 14525934 15485879 | N/A | experimental interaction detection | HPRD |
| TRPM7 | RPL27 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| TRPM7 | MYH9 | 16407977 18394644 18675813 27898060 | N/A | N/A | OmniPath |
| PLCB1 | TRPM7 | 11941371 22180838 27898060 | inhibition | N/A | OmniPath |
| PLCG1 | TRPM7 | 11941371 27898060 | inhibition | N/A | OmniPath |
| TRPM7 | TRPM6 | 14976260 24385424 27898060 | stimulant | N/A | OmniPath |
| TRPM6 | TRPM7 | 14976260 24385424 27898060 | stimulant | N/A | OmniPath |
| TRPM7 | ANXA1 | 15485879 20068231 21280599 24103589 24939696 27898060 | stimulant | N/A | OmniPath |
| RACK1 | TRPM7 | 18258429 27898060 | inhibition | N/A | OmniPath |
| PLCB2 | TRPM7 | 11941371 22180838 27898060 | inhibition | N/A | OmniPath |
| PLCB3 | TRPM7 | 11941371 22180838 27898060 | inhibition | N/A | OmniPath |
| TRPM7 | KDR | 10579917 11435426 11741094 27898060 | N/A | N/A | OmniPath |
| TRPM7 | EEF2K | 21112387 27898060 | stimulant | N/A | OmniPath |
| TRPM7 | TMOD1 | 19137675 27898060 | N/A | N/A | OmniPath |