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GENE：IFNAR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IFNAR2
FullNmae interferon alpha and beta receptor subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5433
EnsembleID ENSG00000159110
Uniprot P48551

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IFNAR2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNAR2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IFNAR2 GO:0004905,GO:0004905,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0007166,GO:0007259,GO:0008269,GO:0009615,GO:0019901,GO:0019955,GO:0035455,GO:0035455,GO:0035456,GO:0035456,GO:0035458,GO:0042018,GO:0046425,GO:0051607,GO:0060337,GO:0060337,GO:0060337,GO:0060337,GO:0098586,GO:0140865

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IFNAR2 hsa:3455 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04217 Necroptosis - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05160 Hepatitis C - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05162 Measles - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05164 Influenza A - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IFNAR2 hsa:3455 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNAR2 IFNAR1 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21854986 21930765 21930769 23180781 26192618 7512720 7521688 7543512 interaction type,physical association x-ray crystallography ACSN,InnateDB
JAK1 IFNAR2 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 26192618 7512720 7521688 7543512 interaction type N/A ACSN
TYK2 IFNAR2 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 26192618 7512720 7521688 7543512 interaction type N/A ACSN
IFNAR2 STAT1 10582086 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 23180781 23331499 26192618 7512720 7521688 7543512 9121453 interaction type,physical association pull down ACSN,InnateDB,SignaLink,SignaLink
IFNAR2 IL15 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
IFNAR2 IL15RA 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
IFNAR2 STAT2 10582086 11786546 12220192 18456457 18988627 23180781 23331499 9121453 interaction type,physical association anti tag coimmunoprecipitation,gst pull down,pull down,surface plasmon resonance InnateDB,SignaLink,SignaLink
IFNAR2 PCBP2 18687895 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNAR2 MAPKAP1 18687895 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNAR2 IRF9 17923090 18456457 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IFNAR2 CREBBP 17923090 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNAR2 IFNA2 10339405 17001036 18027911 21854986 23180781 physical association cross-linking study,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,solid phase assay InnateDB
IFNAR2 RACK1 11046044 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
IFNAR2 IL10RA 23180781 9312047 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
IFNAR2 IL10 23180781 9312047 physical association cross-linking study InnateDB
IFNAR2 JAK1 12133952 18988627 23180781 23331499 7988557 stimulation,physical association pull down InnateDB,SignaLink,SignaLink
IFNAR2 BCL6 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNAR2 IL22 10875937 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNAR2 IFNW1 21854986 23180781 physical association x-ray crystallography InnateDB
IFNA1 IFNAR2 23331499 8181059 stimulation N/A SignaLink,SignaLink
IFNB1 IFNAR2 23331499 8181059 stimulation N/A SignaLink,SignaLink
IFNAR2 TYK2 12040185 12960323 18988627 23331499 stimulation N/A SignaLink,SignaLink
IFNK IFNAR2 17208301 23331499 stimulation N/A SignaLink
IL36G IFNAR2 17208301 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 IFNAR2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IFNAR2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 IFNAR2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IFNAR2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IFNAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 IFNAR2 17242205 22473208 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00005651EE IFNAR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 IFNAR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000075ADAC IFNAR2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075A9CF IFNAR2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 IFNAR2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 IFNAR2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 IFNAR2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 IFNAR2 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 IFNAR2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 IFNAR2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 IFNAR2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 IFNAR2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 IFNAR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 IFNAR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 IFNAR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C IFNAR2 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 IFNAR2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C IFNAR2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA IFNAR2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C IFNAR2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D IFNAR2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 IFNAR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC IFNAR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C IFNAR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 IFNAR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE IFNAR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F IFNAR2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STAT1 IFNAR2 11301323 14525934 24234451 25348397 9121453 association,physical association experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
RACK1 IFNAR2 11046044 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
GRAP2 IFNAR2 25348397 N/A physical interaction ComPPI
CREBBP IFNAR2 17923090 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EP300 IFNAR2 17923090 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IFNW1 IFNAR2 21854986 24234451 25348397 N/A x-ray crystallography ComPPI,IntAct
IFNAR1 IFNAR2 14525934 15389589 21854986 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction ComPPI,HPRD,IntAct
IFNA2 IFNAR2 10339405 11888273 14525934 21854986 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
IFNB1 IFNAR2 10395669 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical ComPPI,HPRD
STAT2 IFNAR2 11786546 14525934 17923090 24234451 25348397 9121453 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
JAK1 IFNAR2 12133952 14525934 16710296 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
USP18 IFNAR2 14525934 16710296 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
IFNA1 IFNAR2 25348397 N/A physical interaction,biochemical ComPPI
IFNA8 IFNAR2 14525934 25348397 8969169 N/A experimental interaction detection,physical interaction,biochemical ComPPI,HPRD
IFNA5 IFNAR2 10395669 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical ComPPI,HPRD
IRF9 IFNAR2 17923090 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,far western blotting,physical interaction ComPPI,IntAct
PPP1R3B IFNAR2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IFNAR2 TYK2 12960323 14525934 N/A experimental interaction detection HPRD
STAT3 IFNAR2 12105218 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
PRKCB IFNAR2 14525934 16000408 N/A experimental interaction detection HPRD
IFNAR2 IFNAR2 22807449 24234451 N/A electrophoretic mobility-based method IntAct
IFNAR2 RACK1 11046044 11301323 27898060 N/A N/A OmniPath
IL10 IFNAR2 27898060 9312047 N/A N/A OmniPath
IFNAR2 STAT1 11301323 27898060 9121453 stimulant N/A OmniPath
IL10RA IFNAR2 27898060 9312047 N/A N/A OmniPath
IFNAR1 IFNAR2 11698684 15389589 21854986 27898060 8969169 N/A N/A OmniPath
IFNAR2 IFNAR1 11698684 15389589 21854986 27898060 8969169 N/A N/A OmniPath
JAK1 IFNAR2 12133952 16710296 27898060 7988557 9334213 N/A N/A OmniPath
IFNAR2 JAK1 12133952 16710296 27898060 7988557 9334213 stimulant N/A OmniPath
IFNAR2 TYK2 12040185 1296032 12960323 27898060 stimulant N/A OmniPath
IFNAR2 CREBBP 17923090 27898060 N/A N/A OmniPath
CREBBP IFNAR2 17923090 27898060 stimulant N/A OmniPath
IFNAR2 STAT2 11786546 12220192 17923090 18456457 27898060 9121453 stimulant N/A OmniPath
STAT2 IFNAR2 11786546 12220192 17923090 18456457 27898060 9121453 N/A N/A OmniPath
IFNB1 IFNAR2 10395669 11278538 27898060 7623815 8181059 stimulant N/A OmniPath
IL22 IFNAR2 10875937 27898060 N/A N/A OmniPath
IFNAR2 IFNA2 10339405 10395669 10984492 11888273 17001036 18027911 21854986 27898060 N/A N/A OmniPath
IFNAR2 IRF9 17923090 18456457 27898060 stimulant N/A OmniPath
IRF9 IFNAR2 17923090 18456457 27898060 stimulant N/A OmniPath
IFNAR2 PCBP2 18687895 27898060 N/A N/A OmniPath
IFNA1 IFNAR2 10395669 11278538 11698684 21856167 27898060 8181059 stimulant N/A OmniPath
IFNAR2 MAPKAP1 18687895 27898060 N/A N/A OmniPath
IFNA17 IFNAR2 21856167 27898060 7623815 N/A N/A OmniPath
IFNW1 IFNAR2 11278538 21854986 27898060 stimulant N/A OmniPath
IFNA16 IFNAR2 21856167 27898060 N/A N/A OmniPath
IFNA6 IFNAR2 21856167 27898060 N/A N/A OmniPath
IFNA7 IFNAR2 21856167 27898060 N/A N/A OmniPath
IFNA10 IFNAR2 21856167 27898060 N/A N/A OmniPath
IFNA4 IFNAR2 21856167 27898060 N/A N/A OmniPath
IFNA14 IFNAR2 21856167 27898060 N/A N/A OmniPath
IFNA21 IFNAR2 21856167 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B8A6B IFNAR2 27087310 direct interaction,inhibition N/A NPInter

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