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GENE：IFNGR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IFNGR1
FullNmae interferon gamma receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5439
EnsembleID ENSG00000027697
Uniprot P15260

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IFNGR1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNGR1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNGR1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IFNGR1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature

Go Annotation:

GeneSymbol Go id
IFNGR1 GO:0001774,GO:0004896,GO:0004906,GO:0005515,GO:0005886,GO:0005886,GO:0007165,GO:0009615,GO:0010628,GO:0016020,GO:0019221,GO:0019955,GO:0032760,GO:0038196,GO:0048143,GO:0060333,GO:0060333,GO:0098586,GO:1900222,GO:1902004

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IFNGR1 hsa:3459 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04217 Necroptosis - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05142 Chagas disease - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05152 Tuberculosis - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05164 Influenza A - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
IFNGR1 hsa:3459 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNGR1 IFNGR2 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12438563 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16467876 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24243840 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7512720 7521688 9834059 9864217 interaction type,physical association inferred by curator ACSN,Reactome
IFNG IFNGR1 10485906 10986460 11250200 11489965 11579131 11777960 11867689 11870632 11964313 12165521 12413632 12438563 12811837 12818165 12915721 1396683 14607900 14610620 15143187 15530433 15634932 15778339 15811952 15814715 16237089 16286920 16424049 16467876 16713974 17016554 17559085 17683974 1825141 18272812 18591661 18988627 19833085 20038811 20304997 20406969 20819927 21149606 21411734 21840487 23180781 23331499 24091328 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7510216 7512720 7514165 7521688 7615558 7617032 7673114 8550631 8631301 9111318 9834059 9864217 interaction type,stimulation,physical association cross-linking study,nuclear magnetic resonance,inferred by curator ACSN,InnateDB,Reactome,SignaLink,SignaLink
JAK1 IFNGR1 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26192618 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217 interaction type N/A ACSN
JAK2 IFNGR1 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26192618 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217 interaction type N/A ACSN
IFNGR1 STAT1 10485906 10582086 10848598 11489965 11579131 11777960 11867689 11870632 11964313 11972023 12040185 12413632 12811837 12818165 14607900 14610620 15322115 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21071413 21149606 21411734 21840487 23331499 24091328 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7512720 7521688 7657660 7690989 7796299 8156998 8631301 9834059 9864217 interaction type,physical association inferred by curator ACSN,Reactome,SignaLink,SignaLink
IRF4 IFNGR1 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
SOCS1 IFNGR1 10485906 12193701 12223527 12811837 15522878 18708154 18988627 21469115 23124025 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
STAT1 IFNGR1 10848598 23180781 8605876 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IRF2 IFNGR1 18281489 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNGR1 JAK1 12040185 12133952 12438563 16467876 23180781 23331499 24243840 29145629 stimulation,physical association pull down,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
IRF1 IFNGR1 16785527 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IDO1 IFNGR1 16785527 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNGR2 IFNGR1 12438563 16467876 23180781 physical association fluorescent resonance energy transfer InnateDB
BCL6 IFNGR1 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 IFNGR1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNGR1 IFNGR1 12438563 16467876 24243840 29145629 physical association inferred by curator Reactome
IFNGR1 PTPN1 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
IFNGR1 PTPN6 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
IFNGR1 PRKCD 11972023 15322115 29145629 enzymatic reaction inferred by curator Reactome
IFNGR1 JAK2 12040185 23331499 stimulation N/A SignaLink,SignaLink
IFNAR1 IFNGR1 18929502 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SOCS1 IFNGR1 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 IFNGR1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IFNGR1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IFNGR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF2 IFNGR1 18281489 trascriptional regulation,stimulation inferred by curator TFlink
SP1 IFNGR1 11477089 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IFNGR1 11477089 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 IFNGR1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC IFNGR1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A IFNGR1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 IFNGR1 19877012 rna interference,inhibition experimental interaction detection,northern blot,miRNA interference luciferase reporter assay miRSponge
URS0000338542 IFNGR1 19877012 25416803 mrna cleavage,inhibition experimental interaction detection,northern blot,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 IFNGR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000058BB84 IFNGR1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D1FC IFNGR1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC IFNGR1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 IFNGR1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B IFNGR1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C IFNGR1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STAT4 IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 STAT4 25361965 interaction type N/A PTMCode2
IFNGR2 IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 IFNGR2 25361965 interaction type N/A PTMCode2
JAK1 IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 JAK1 25361965 interaction type N/A PTMCode2
IFNG IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 IFNG 25361965 interaction type N/A PTMCode2
IFNGR1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IFNGR1 25361965 interaction type N/A PTMCode2
CANX IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 CANX 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAD2L2 IFNGR1 25348397 N/A physical interaction ComPPI
STAT1 IFNGR1 14525934 15494521 15780933 24234451 25348397 7514165 8156998 8662591 association coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,competition binding,in vivo ComPPI,HPRD,IntAct
TMEM100 IFNGR1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAC1 IFNGR1 14525934 15494521 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SOCS1 IFNGR1 14525934 15522878 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 IFNGR1 10022928 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC IFNGR1 25348397 N/A physical interaction ComPPI
CANX IFNGR1 14525934 25348397 27898060 8136357 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
IFNGR1 IFNGR2 14525934 25348397 7673114 N/A experimental interaction detection,in vivo ComPPI,HPRD
IFNGR1 IFNG 10986460 11250200 12165521 14525934 24234451 25348397 7617032 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IFNGR1 JAK1 12133952 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IFNGR1 JAK2 11438544 14525934 25348397 7499845 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IFNGR1 H3C15 25348397 N/A physical interaction ComPPI
IFNGR1 DTX3L 25348397 N/A physical interaction ComPPI
IFNGR1 SHMT2 25348397 N/A physical interaction ComPPI
IFNGR1 MOV10 25348397 N/A physical interaction ComPPI
IFNGR1 NXF1 25348397 N/A physical interaction ComPPI
IFNGR1 TSPAN3 25348397 N/A physical interaction ComPPI
IFNGR1 IL20RB 25348397 N/A physical interaction ComPPI
IFNGR1 TNFRSF10B 25348397 N/A physical interaction ComPPI
IFNGR1 BMPR1A 25348397 N/A physical interaction ComPPI
IFNGR1 NDFIP1 25348397 N/A physical interaction ComPPI
IFNGR1 CD320 25348397 N/A physical interaction ComPPI
IFNGR1 RHOU 25348397 N/A physical interaction ComPPI
IFNGR1 RAET1E 25348397 N/A physical interaction ComPPI
IFNGR1 SLC9A6 25348397 N/A physical interaction ComPPI
IFNGR1 FGFR1 25348397 N/A physical interaction ComPPI
IFNGR1 TMEM30B 25348397 N/A physical interaction ComPPI
IFNGR1 NOTCH3 25348397 N/A physical interaction ComPPI
IFNGR1 ADGRG5 25348397 N/A physical interaction ComPPI
IFNGR1 RUSF1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR1 LRP10 25348397 N/A physical interaction ComPPI
IFNGR1 NFKB1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
IFNGR1 NINJ2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR1 STIM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR1 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR1 IFNGR1 10986460 14525934 N/A experimental interaction detection HPRD
SOCS3 IFNGR1 14525967 27898060 inhibition N/A OmniPath
SOCS1 IFNGR1 15522878 1552288 18708154 27898060 inhibition,stimulant N/A OmniPath
IFNGR1 STAT1 10848598 15494521 15780933 21689637 27898060 7514165 7615558 8156998 8605876 8662591 stimulant N/A OmniPath
STAT1 IFNGR1 10848598 15494521 15780933 21689637 27898060 7514165 7615558 8156998 8605876 8662591 N/A N/A OmniPath
IFNAR1 IFNGR1 18929502 27898060 stimulant N/A OmniPath
IFNGR1 JAK1 12040185 12133952 15864272 17063185 19041276 21689637 27898060 7615558 7796299 8232552 8550631 8649432 stimulant N/A OmniPath
JAK1 IFNGR1 12133952 15864272 17063185 19041276 21689637 27898060 7615558 7796299 8156998 8232552 8550631 8649432 stimulant N/A OmniPath
IFNG IFNGR1 10811850 10860730 10986460 11250200 12165521 12438563 16110316 23898330 27898060 7617032 7673114 stimulant N/A OmniPath
IFNGR1 IFNG 10860730 10986460 11250200 12165521 27898060 7617032 7673114 N/A N/A OmniPath
JAK2 IFNGR1 11438544 15864272 17063185 21689637 23898330 27898060 7499845 7673114 stimulant N/A OmniPath
IFNGR1 JAK2 11438544 12040185 15864272 17063185 21689637 23898330 27898060 7499845 7673114 stimulant N/A OmniPath
IFNGR1 IFNGR2 10811850 12438563 1531478 16467876 2532365 27898060 2971451 7673114 8124716 8124717 9208871 N/A N/A OmniPath
IFNGR2 IFNGR1 10811850 12438563 1531478 16467876 2532365 27898060 2971451 7673114 8124716 8124717 9208871 N/A N/A OmniPath

Visualization










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