Gene Information gene info

  1. Home

GENE：IFNGR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IFNGR2
FullNmae interferon gamma receptor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5440
EnsembleID ENSG00000159128
Uniprot P38484

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IFNGR2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNGR2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNGR2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IFNGR2 GO:0000139,GO:0001774,GO:0004896,GO:0004906,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0007166,GO:0009615,GO:0019221,GO:0030659,GO:0038196,GO:0051607,GO:0060333,GO:0098586

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IFNGR2 hsa:3460 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04217 Necroptosis - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05142 Chagas disease - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05152 Tuberculosis - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05164 Influenza A - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
IFNGR2 hsa:3460 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNGR1 IFNGR2 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12438563 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16467876 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24243840 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7512720 7521688 9834059 9864217 interaction type,physical association inferred by curator ACSN,Reactome
IFNG IFNGR2 10485906 10986460 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12438563 12811837 12818165 12915721 1396683 14607900 14610620 15143187 15530433 15634932 15778339 15811952 15814715 16237089 16286920 16424049 16467876 16713974 17016554 17559085 17683974 1825141 18272812 18591661 18988627 19833085 20038811 20304997 20406969 20819927 21149606 21411734 21840487 23331499 24091328 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7510216 7512720 7514165 7521688 7615558 7617032 7673114 8550631 8631301 9111318 9834059 9864217 interaction type,stimulation,physical association inferred by curator ACSN,Reactome,SignaLink,SignaLink
JAK1 IFNGR2 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12438563 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16467876 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24243840 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7512720 7521688 9834059 9864217 interaction type,physical association inferred by curator ACSN,Reactome
JAK2 IFNGR2 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26192618 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217 interaction type N/A ACSN
IFNGR2 STAT1 10485906 10582086 11489965 11579131 11777960 11867689 11870632 11964313 11972023 12040185 12413632 12811837 12818165 14607900 14610620 15322115 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 23331499 24091328 24658051 26192618 26755705 27216177 29145629 2965306 6425450 7512720 7521688 7657660 7690989 7796299 8156998 8631301 9834059 9864217 interaction type,stimulation,physical association inferred by curator ACSN,Reactome,SignaLink,SignaLink
IRF4 IFNGR2 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
SOCS1 IFNGR2 10485906 12193701 12223527 12811837 21469115 23124025 26192618 interaction type N/A ACSN
IFNGR2 ANXA5 16670301 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
IFNGR2 IFNG 23180781 7673114 physical association cross-linking study InnateDB
IFNGR2 IFNGR1 12438563 16467876 23180781 physical association fluorescent resonance energy transfer InnateDB
IFNGR2 IFNGR2 12438563 16467876 23180781 24243840 29145629 physical association fluorescent resonance energy transfer,inferred by curator InnateDB,Reactome
PTPN1 IFNGR2 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
PTPN6 IFNGR2 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
IFNGR2 PRKCD 11972023 15322115 29145629 enzymatic reaction inferred by curator Reactome
IFNGR2 JAK1 15120645 23331499 stimulation N/A SignaLink,SignaLink
IFNGR2 JAK2 16381926 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR IFNGR2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IFNGR2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IFNGR2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IFNGR2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IFNGR2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IFNGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 IFNGR2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000002103A IFNGR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C IFNGR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000134ADC IFNGR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F IFNGR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 IFNGR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 IFNGR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 IFNGR2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IFNGR2 IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 IFNGR2 25361965 interaction type N/A PTMCode2
IFNGR2 JAK3 25361965 interaction type N/A PTMCode2
JAK3 IFNGR2 25361965 interaction type N/A PTMCode2
DNAJA3 IFNGR2 25361965 interaction type N/A PTMCode2
IFNGR2 DNAJA3 25361965 interaction type N/A PTMCode2
IFNG IFNGR2 25361965 interaction type N/A PTMCode2
IFNGR2 IFNG 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SMIM3 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ADIPOQ IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM199 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SFTPC IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CXCL9 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPL37A IFNGR2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RTP2 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
JAGN1 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
INSIG2 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PMP22 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR1 IFNGR2 14525934 25348397 7673114 N/A experimental interaction detection,in vivo ComPPI,HPRD
IFNGR2 ANXA5 14525934 16670301 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
IFNGR2 NR3C1 14525934 25348397 8349631 N/A experimental interaction detection,in vitro ComPPI,HPRD
IFNGR2 IFNG 14525934 25348397 7673114 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IFNGR2 JAK2 14525934 25348397 7514165 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IFNGR2 ELAVL1 25348397 N/A physical interaction ComPPI
IFNGR2 CAMK2D 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IFNGR2 TRIM25 25348397 N/A physical interaction ComPPI
IFNGR2 UNC50 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 GIMAP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 ERMP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 SLC52A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 TMEM60 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 CD302 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 TMEM254 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNGR2 TMEM97 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DNAJA3 IFNGR2 11679576 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ZDHHC24 IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM120B IFNGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAR2A IFNGR2 24234451 27621415 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy IntAct
IFNGR1 IFNGR2 10811850 12438563 1531478 16467876 2532365 27898060 2971451 7673114 8124716 8124717 9208871 N/A N/A OmniPath
IFNGR2 IFNGR1 10811850 12438563 1531478 16467876 2532365 27898060 2971451 7673114 8124716 8124717 9208871 N/A N/A OmniPath
IFNGR2 STAT1 10582086 27898060 stimulant N/A OmniPath
JAK1 IFNGR2 19041276 27898060 stimulant N/A OmniPath
IFNGR2 JAK1 15120645 27898060 stimulant N/A OmniPath
IFNG IFNGR2 10811850 12438563 27898060 7673114 stimulant N/A OmniPath
IFNGR2 IFNG 27898060 7673114 N/A N/A OmniPath
JAK2 IFNGR2 23898330 27898060 7514165 7901766 stimulant N/A OmniPath
IFNGR2 JAK2 16381926 23898330 27898060 7514165 7901766 stimulant N/A OmniPath
IFNGR2 ANXA5 16670301 27898060 N/A N/A OmniPath

Visualization










  Return