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GENE：PPID

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPID
FullNmae peptidylprolyl isomerase D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9257
EnsembleID ENSG00000171497
Uniprot Q08752

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPID necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPID necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPID GO:0000122,GO:0000413,GO:0000413,GO:0003755,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0006457,GO:0006457,GO:0006915,GO:0008134,GO:0015031,GO:0016018,GO:0016018,GO:0016018,GO:0019076,GO:0030331,GO:0030544,GO:0031072,GO:0034389,GO:0043065,GO:0045070,GO:0050714,GO:0051879,GO:0061077,GO:0065003,GO:0071492

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPID hsa:5481 path:hsa04217 Necroptosis - Homo sapiens (human)
PPID hsa:5481 path:hsa04218 Cellular senescence - Homo sapiens (human)
PPID hsa:5481 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PPID hsa:5481 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PPID hsa:5481 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPID TSPO 15033708 17568748 18309324 20080742 20823910 21887410 25486353 26192618 interaction type N/A ACSN
APP PPID 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PPID 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PPID 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
MYC PPID 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PPID 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PPID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPID 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 PPID 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000324096 PPID 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001CF056 PPID 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000B7E30 PPID 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000003BF62 PPID 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PPID 22927820 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIN1 PPID 25361965 interaction type N/A PTMCode2
PPID PIN1 25361965 interaction type N/A PTMCode2
HSPA8 PPID 25361965 interaction type N/A PTMCode2
PPID HSPA8 25361965 interaction type N/A PTMCode2
SLC25A4 PPID 25361965 interaction type N/A PTMCode2
PPID SLC25A4 25361965 interaction type N/A PTMCode2
PPID HSP90AB1 25361965 interaction type N/A PTMCode2
HSP90AB1 PPID 25361965 interaction type N/A PTMCode2
PPID HSP90AA1 25361965 interaction type N/A PTMCode2
HSP90AA1 PPID 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 PPID 14525934 15497503 21146485 24234451 25348397 association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
UROD PPID 25348397 N/A physical interaction ComPPI
NPM1 PPID 25348397 N/A physical interaction ComPPI
TMA16 PPID 25348397 N/A physical interaction ComPPI
ILF2 PPID 21146485 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPID HSP90AB1 14525934 15497503 16650407 21146485 24234451 25348397 27898060 association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct,OmniPath
PPID SMURF2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPID HAP1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PPID KAT7 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPID SLC25A4 12149099 14525934 14729611 15033717 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PPID HSP90AA1 10642522 12145316 14525934 20188096 20661446 21146485 24234451 25348397 27898060 8662874 association two hybrid,experimental interaction detection,physical interaction,in vitro,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct,OmniPath
PPID ESR1 25348397 N/A physical interaction ComPPI
PPID FES 25348397 N/A physical interaction ComPPI
PPID HSF1 25348397 N/A physical interaction ComPPI
PPID CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPID PLK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPID LNX1 25348397 N/A physical interaction ComPPI
PPID NR3C1 25348397 N/A physical interaction ComPPI
PPID NR3C2 25348397 N/A physical interaction ComPPI
PPID AR 25348397 N/A physical interaction ComPPI
PPID HSP90AA2P 25348397 N/A physical interaction ComPPI
PPID APP 14525934 18806802 21832049 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PPID FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PPID RACK1 21146485 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPID RPS3 21146485 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPID HSPA1A 25348397 N/A physical interaction ComPPI
PPID HSPA1B 25348397 N/A physical interaction ComPPI
PPID XRCC6 21146485 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPID TUBA1A 25348397 N/A physical interaction ComPPI
PPID TUBB 25348397 N/A physical interaction ComPPI
PPID S100A2 25348397 N/A physical interaction ComPPI
PPID S100A6 25348397 N/A physical interaction ComPPI
PPID S100A1 25348397 N/A physical interaction ComPPI
PPID FBXO25 25348397 N/A physical interaction ComPPI
PPID GCLC 25348397 N/A physical interaction ComPPI
PPID PSAT1 25348397 N/A physical interaction ComPPI
PPID BCL2 25348397 N/A physical interaction ComPPI
PPID AHSA1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPID CDC37 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPID GPALPP1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPID PTGES3 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPID TRIM27 25348397 N/A physical interaction ComPPI
PPID PCBP4 25348397 N/A physical interaction ComPPI
PPID UNK 25348397 N/A physical interaction ComPPI
PPID PKM 25348397 N/A physical interaction ComPPI
PPID DNAJB1 25348397 N/A physical interaction ComPPI
PPID OAT 25348397 N/A physical interaction ComPPI
PPID STIP1 25348397 N/A physical interaction ComPPI
PPID PSMD12 25348397 N/A physical interaction ComPPI
PPID SF1 25348397 N/A physical interaction ComPPI
PPID NTRK1 25348397 N/A physical interaction ComPPI
PPID FGB 25348397 N/A physical interaction ComPPI
PPID AEN 25348397 N/A physical interaction ComPPI
PPID CCDC83 25348397 N/A physical interaction ComPPI
PPID AKIRIN2 25348397 N/A physical interaction ComPPI
PPID AMTN 25348397 N/A physical interaction ComPPI
PPID FGF9 25348397 N/A physical interaction ComPPI
PPID IQCB1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PPID MAPK1 20080742 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPID GSK3B 20080742 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPID VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
PPID ACTB 21146485 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PPID TUBB4B 21146485 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PPID TUBA1B 21146485 24234451 25348397 association tandem affinity purification ComPPI,IntAct
HPRT1 PPID 25348397 N/A physical interaction ComPPI
IMMT PPID 24234451 30021884 physical association cross-linking study IntAct

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